PMID- 31321348
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2465-9525 (Print)
IS  - 2465-9541 (Electronic)
IS  - 2465-9525 (Linking)
VI  - 23
IP  - 2
DP  - 2019 Jun
TI  - T Lymphocyte Development and Activation in Humanized Mouse Model.
PG  - 79-92
LID - 10.12717/DR.2019.23.2.079 [doi]
AB  - Humanized mice, containing engrafted human cells and tissues, are emerging as an 
      important in vivo platform for studying human diseases. Since the development of 
      Nod scid gamma (NSG) mice bearing mutations in the IL-2 receptor gamma chain, 
      many investigators have used NSG mice engrafted with human hematopoietic stem 
      cells (HSCs) to generate functional human immune systems in vivo, results in high 
      efficacy of human cell engraftment. The development of NSG mice has allowed 
      significant advances to be made in studies on several human diseases, including 
      cancer and graft-versus-host-disease (GVHD), and in regenerative medicine. Based 
      on the human HSC transplantation, organ transplantation including thymus and 
      liver in the renal capsule has been performed. Also, immune reconstruction of 
      cells, of the lymphoid as well as myeloid lineages, has been partly accomplished. 
      However, crosstalk between pluripotent stem cell derived therapeutic cells with 
      human leukocyte antigen (HLA) mis/matched types and immune CD3 T cells have not 
      been fully addressed. To overcome this hurdle, human major histocompatibility 
      complex (MHC) molecules, not mouse MHC molecules, are required to generate 
      functional T cells in a humanized mouse model. Here, we briefly summarize 
      characteristics of the humanized mouse model, focusing on development of CD3 T 
      cells with MHC molecules. We also highlight the necessity of the humanized mouse 
      model for the treatment of various human diseases.
FAU - Lee, Ji Yoon
AU  - Lee JY
AD  - Dept. of Biomedical Science, CHA University, Seongnam 13488, Korea.
FAU - Han, A-Reum
AU  - Han AR
AD  - Dept. of Biomedical Science, CHA University, Seongnam 13488, Korea.
FAU - Lee, Dong Ryul
AU  - Lee DR
AD  - Dept. of Biomedical Science, CHA University, Seongnam 13488, Korea.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190630
PL  - Korea (South)
TA  - Dev Reprod
JT  - Development & reproduction
JID - 101178352
PMC - PMC6635618
OTO - NOTNLM
OT  - Humanized mouse model
OT  - MHC mol-ecules
OT  - Stem cells
OT  - T cell development
EDAT- 2019/07/20 06:00
MHDA- 2019/07/20 06:01
PMCR- 2019/06/01
CRDT- 2019/07/20 06:00
PHST- 2019/03/29 00:00 [received]
PHST- 2019/04/12 00:00 [revised]
PHST- 2019/04/28 00:00 [accepted]
PHST- 2019/07/20 06:00 [entrez]
PHST- 2019/07/20 06:00 [pubmed]
PHST- 2019/07/20 06:01 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
AID - dr-23-2-79 [pii]
AID - 10.12717/DR.2019.23.2.079 [doi]
PST - ppublish
SO  - Dev Reprod. 2019 Jun;23(2):79-92. doi: 10.12717/DR.2019.23.2.079. Epub 2019 Jun 
      30.