PMID- 31322509
OWN - NLM
STAT- MEDLINE
DCOM- 20191029
LR  - 20191029
IS  - 1512-0112 (Print)
IS  - 1512-0112 (Linking)
IP  - 290
DP  - 2019 May
TI  - CORRELATION BETWEEN LEVELS OF HOMOCYSTEINE, ANTI-MULLERIAN HORMONE AND INSULIN 
      RESISTANCE IN PCOS PATIENTS WITH RECURRENT MISCARRIAGE.
PG  - 25-29
AB  - There are controversial opinions regarding the impact of hyperhomocysteinemia 
      (HHcy) and insulin resistance in PCOS patients who experience Recurrent Pregnancy 
      Loss (RPL). Nowadays the correlation between levels of anti-mullerian hormone 
      (AMH), homocysteine and insulin resistance (IR) have become the main subject of 
      interest in PCOS patients for predicting RPL. Objective - investigate the 
      relationship between level of homocysteine, anti-mullerian hormone and insulin 
      resistance in PCOS patients with Recurrent Pregnancy Loss. 80 Georgian young 
      women (<30 years) with PCOS were involved in the prospective study. The diagnosis 
      of PCOS was based on the criteria of Rotterdam Consensus 2003. Patients were 
      divided into two groups: group I-50 patients, who experienced RPL, and group 
      II-30 patients with live births in anamnesis (control group). Patients with RPL 
      were divided into two subgroups: subgroup A-with insulin resistance (n=28), and 
      subgroup B-without insulin resistance (n=22). All patients underwent hormonal 
      investigation from day 2 to 3 of menstrual cycle. Plasma levels of anti-mullerian 
      hormone, homocysteine, follicle-stimulating hormone, luteinizing hormone (LH), 
      total testosterone (T), free testosterone (FT), sex hormone binding globulin 
      (SHBG) were determined. Between 2-3 days of the menstrual cycle all participants 
      underwent an ultrasound examination using Voluson E10. This was done to determine 
      ovarian volume and antral follicle count. Average homocysteine (Hcy) level in 
      PCOS patients with RPL (11.5+/-2.24mumol/l) was significantly higher than in 
      controls (7.55+/-2.45 mumol/l, p<0.001). Incidence of (HHcy) and IR in patients with 
      RPL was 70% and 56% respectively, which was significantly higher than in controls 
      (HHcy-54.3%; IR- 9.4%; p<0.0001). HOMA-IR in patients with RPL was significantly 
      higher compared with controls (p<0.001). Average AMH level in patients with RPL 
      and live births did not differ significantly. In the group of PCOS with RPL 
      significant positive correlation between Hcy and HOMA-IR, BMI, AMH and FT levels 
      was found (p<0.001). Serum homocysteine level is elevated in PCOS patients with 
      RPL. This elevation is correlated with the degree of obesity, BMI, Insulin 
      Resistance status, AMH and androgen levels. The treatment of hyperhomocysteinemia 
      and insulin resistance in women with PCOS might become the bases for prevention 
      of pregnancy losses and improving reproductive outcomes.
FAU - Asanidze, E
AU  - Asanidze E
AD  - 1I. Javakhishvili Tbilisi State University; Center for Reproductive Medicine 
      "Universe".
FAU - Kristesashvili, J
AU  - Kristesashvili J
AD  - 1I. Javakhishvili Tbilisi State University; Center for Reproductive Medicine 
      "Universe".
FAU - Andguladze, S
AU  - Andguladze S
AD  - 2Medical Corporation "Evex", Tbilisi, Georgia.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Georgia (Republic)
TA  - Georgian Med News
JT  - Georgian medical news
JID - 101218222
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 3XMK78S47O (Testosterone)
RN  - 80497-65-0 (Anti-Mullerian Hormone)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
SB  - IM
MH  - Abortion, Habitual/blood/epidemiology/*etiology
MH  - Adult
MH  - Anti-Mullerian Hormone/*blood
MH  - Female
MH  - Follicle Stimulating Hormone/blood
MH  - Homocysteine/*blood
MH  - Humans
MH  - *Insulin Resistance
MH  - Luteinizing Hormone/blood
MH  - Polycystic Ovary Syndrome/*blood/complications/metabolism
MH  - Pregnancy
MH  - Prospective Studies
MH  - Testosterone/blood
EDAT- 2019/07/20 06:00
MHDA- 2019/10/30 06:00
CRDT- 2019/07/20 06:00
PHST- 2019/07/20 06:00 [entrez]
PHST- 2019/07/20 06:00 [pubmed]
PHST- 2019/10/30 06:00 [medline]
PST - ppublish
SO  - Georgian Med News. 2019 May;(290):25-29.