PMID- 31324048
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 8
IP  - 7
DP  - 2019 Jul 9
TI  - Emerging Roles of Sestrins in Neurodegenerative Diseases: Counteracting Oxidative 
      Stress and Beyond.
LID - 10.3390/jcm8071001 [doi]
LID - 1001
AB  - Low levels of reactive oxygen species (ROS) are critical for the operation of 
      regular neuronal function. However, heightened oxidative stress with increased 
      contents of oxidation markers in DNA, lipids, and proteins with compromised 
      antioxidant capacity may play a harmful role in the brain and may be implicated 
      in the pathophysiology of neurodegenerative diseases. Sestrins, a family of 
      evolutionarily-conserved stress-inducible proteins, are actively regulated by 
      assorted stresses, such as DNA damage, hypoxia, and oxidative stress. Three 
      highly homologous genes that encode sestrin1, sestrin2, and sestrin3 proteins 
      exist in the genomes of vertebrates. Under stressful conditions, sestrins are 
      activated with versatile functions to cope with different types of stimuli. A 
      growing body of evidence suggests that sestrins, especially sestrin2, can 
      counteract oxidative stress, lessen mammalian/mechanistic target of rapamycin 
      (mTOR) expression, and promote cell survival, thereby playing a critical role in 
      aging-related disorders including neurodegeneration. Strategies capable of 
      augmenting sestrin expression may; thus, facilitate cell adaptation to stressful 
      conditions or environments through stimulation of antioxidant response and 
      autophagy process, which may carry clinical significance in neurodegenerative 
      diseases.
FAU - Chen, Shang-Der
AU  - Chen SD
AUID- ORCID: 0000-0001-7879-2579
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 
      83301, Taiwan.
AD  - Institute for Translation Research in Biomedicine; Kaohsiung Chang Gung Memorial 
      Hospital, Kaohsiung City 83301, Taiwan.
FAU - Yang, Jenq-Lin
AU  - Yang JL
AUID- ORCID: 0000-0002-9897-8087
AD  - Institute for Translation Research in Biomedicine; Kaohsiung Chang Gung Memorial 
      Hospital, Kaohsiung City 83301, Taiwan.
FAU - Lin, Tsu-Kung
AU  - Lin TK
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City 
      83301, Taiwan.
AD  - College of Medicine, Chang Gung University, Taoyuan City 33302, Taiwan.
FAU - Yang, Ding-I
AU  - Yang DI
AD  - Institute of Brain Science, National Yang-Ming University, Taipei 11221, Taiwan. 
      diyang@ym.edu.tw.
AD  - Brain Research Center, National Yang-Ming University, Taipei 11221, Taiwan. 
      diyang@ym.edu.tw.
AD  - Taipei City Hospital, Taipei 10629, Taiwan. diyang@ym.edu.tw.
LA  - eng
GR  - MOST 106-2314-B-010-018-MY3, MOST 107-2314-B-010-020-MY3, MOST 
      106-2314-B-182-031, MOST 107-2314-B-182A-001/Ministry of Science and Technology, 
      Taiwan/
GR  - CMRPG8F1891, CMRPG8F1892, CMRPG8F1513/Chang Gung Medical Foundation/
GR  - 10601-62-003, 10801-62-003/Department of Health in Taipei City Government, 
      Taiwan/
GR  - 107BRC-B408, 108BRC-B407/Ministry of Education, Taiwan/
GR  - 107F-M01/Development and Construction Program for School of Medicine in National 
      Yang-Ming University in Taiwan/
PT  - Journal Article
PT  - Review
DEP - 20190709
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC6678886
OTO - NOTNLM
OT  - autophagy
OT  - mTOR
OT  - neurodegenerative diseases
OT  - oxidative stress
OT  - sestrins
COIS- The authors declare no conflict of interest.
EDAT- 2019/07/22 06:00
MHDA- 2019/07/22 06:01
PMCR- 2019/07/09
CRDT- 2019/07/21 06:00
PHST- 2019/06/06 00:00 [received]
PHST- 2019/07/01 00:00 [revised]
PHST- 2019/07/04 00:00 [accepted]
PHST- 2019/07/21 06:00 [entrez]
PHST- 2019/07/22 06:00 [pubmed]
PHST- 2019/07/22 06:01 [medline]
PHST- 2019/07/09 00:00 [pmc-release]
AID - jcm8071001 [pii]
AID - jcm-08-01001 [pii]
AID - 10.3390/jcm8071001 [doi]
PST - epublish
SO  - J Clin Med. 2019 Jul 9;8(7):1001. doi: 10.3390/jcm8071001.