PMID- 31324966
OWN - NLM
STAT- MEDLINE
DCOM- 20200122
LR  - 20200122
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 257
IP  - 10
DP  - 2019 Oct
TI  - Vitreo-macular interface disorders in retinitis pigmentosa.
PG  - 2137-2146
LID - 10.1007/s00417-019-04418-8 [doi]
AB  - PURPOSE: To investigate the prevalence and progression of vitreo-macular 
      interface disorders (VMID) phenotypes and their natural history in retinitis 
      pigmentosa (RP). METHODS: A total of 257 eyes of 145 RP patients with VMID were 
      retrospectively evaluated. Patients were divided according to the VMID subtypes 
      into epiretinal membranes (ERMs), vitreo-macular traction (VMT) group, and 
      macular hole (MH). Serial eye-tracked spectral-domain optical coherence 
      tomography (SD-OCT) and best-corrected visual acuity (BCVA) changes were analyzed 
      for a mean follow-up of 36.95 months. The status of posterior vitreous cortex was 
      also considered. A control group of 65 eyes belonging to 65 RP patients with no 
      macular changes was also recruited. RESULTS: VMID and control groups had the same 
      baseline BCVA (0.50 vs 0.44 LogMAR) and did not differ in terms of phakic status. 
      Different VMID groups had similar BCVA at baseline (p = 0.98). ERM represented 
      the most prevalent disorder (207/257 eyes, 80.5%), followed by 35/257 (13.6%) 
      VMT, and 15/257 Lamellar MH (LMH) eyes (5.8%). There were no cases of full 
      thickness MH. Throughout the 36.9 months of follow-up, BCVA decreased an average 
      0.09 LogMAR from 0.31 to 0.4 in VMID patients and 0.01 in controls. VMID subgroup 
      analysis showed a significant BCVA decrease in ERM patients (- 20.29%, 
      p < 0.001), while VMT and LMH did not change significantly. Foveal thickness also 
      remained stable over time. Complete PVD was present in 11 eyes in ERM, VMT, and 
      LMH. CONCLUSIONS: Our study confirms the high prevalence of VMID in RP patients; 
      however, only ERMs determined a significant loss of vision over 24 months. The 
      high prevalence of VMID in RP patients suggests that macular alteration other 
      than edema represents part of disease spectrum.
FAU - Fragiotta, Serena
AU  - Fragiotta S
AUID- ORCID: 0000-0002-6214-6270
AD  - Department of Medico-Surgical Sciences and Biotechnologies, U.O.C. Ophthalmology, 
      Sapienza University of Rome, C.so Della Repubblica, 79, 04100, Latina, (LT), 
      Italy. s.fragiotta@hotmail.it.
FAU - Rossi, Tommaso
AU  - Rossi T
AD  - IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
FAU - Carnevale, Carmela
AU  - Carnevale C
AD  - Department of Medico-Surgical Sciences and Biotechnologies, U.O.C. Ophthalmology, 
      Sapienza University of Rome, C.so Della Repubblica, 79, 04100, Latina, (LT), 
      Italy.
FAU - Cutini, Alessandro
AU  - Cutini A
AD  - Department of Medico-Surgical Sciences and Biotechnologies, U.O.C. Ophthalmology, 
      Sapienza University of Rome, C.so Della Repubblica, 79, 04100, Latina, (LT), 
      Italy.
FAU - Tricarico, Stefano
AU  - Tricarico S
AD  - Department of Medico-Surgical Sciences and Biotechnologies, U.O.C. Ophthalmology, 
      Sapienza University of Rome, C.so Della Repubblica, 79, 04100, Latina, (LT), 
      Italy.
FAU - Casillo, Lorenzo
AU  - Casillo L
AD  - Department of Medico-Surgical Sciences and Biotechnologies, U.O.C. Ophthalmology, 
      Sapienza University of Rome, C.so Della Repubblica, 79, 04100, Latina, (LT), 
      Italy.
FAU - Scuderi, Gianluca
AU  - Scuderi G
AD  - Department, NESMOS Department, Ophthalmology Unit, S. Andrea Hospital, University 
      of Rome "La Sapienza", Rome, Italy.
FAU - Vingolo, Enzo Maria
AU  - Vingolo EM
AD  - Department of Medico-Surgical Sciences and Biotechnologies, U.O.C. Ophthalmology, 
      Sapienza University of Rome, C.so Della Repubblica, 79, 04100, Latina, (LT), 
      Italy.
LA  - eng
PT  - Journal Article
DEP - 20190719
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Epiretinal Membrane/diagnosis/*epidemiology/etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Italy/epidemiology
MH  - Macula Lutea/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Retinal Perforations/diagnosis/*epidemiology/etiology
MH  - Retinitis Pigmentosa/complications/*diagnosis
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
MH  - Vitreous Body/*pathology
OTO - NOTNLM
OT  - Epiretinal membrane
OT  - Lamellar macular hole
OT  - Retinitis pigmentosa
OT  - Spectral-domain optical coherence tomography
OT  - Vitreo-macular interface disorders
OT  - Vitreo-macular traction
EDAT- 2019/07/22 06:00
MHDA- 2020/01/23 06:00
CRDT- 2019/07/21 06:00
PHST- 2019/04/10 00:00 [received]
PHST- 2019/07/09 00:00 [accepted]
PHST- 2019/06/29 00:00 [revised]
PHST- 2019/07/22 06:00 [pubmed]
PHST- 2020/01/23 06:00 [medline]
PHST- 2019/07/21 06:00 [entrez]
AID - 10.1007/s00417-019-04418-8 [pii]
AID - 10.1007/s00417-019-04418-8 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2019 Oct;257(10):2137-2146. doi: 
      10.1007/s00417-019-04418-8. Epub 2019 Jul 19.