PMID- 31325379
OWN - NLM
STAT- MEDLINE
DCOM- 20191213
LR  - 20200903
IS  - 1525-3163 (Electronic)
IS  - 0021-8812 (Print)
IS  - 0021-8812 (Linking)
VI  - 97
IP  - 9
DP  - 2019 Sep 3
TI  - Effect of divergence in residual feed intake on expression of lipid 
      metabolism-related genes in the liver of meat-type ducks1.
PG  - 3947-3957
LID - 10.1093/jas/skz241 [doi]
AB  - Lipid metabolism is considered one of the important factors affecting residual 
      feed intake (RFI). However, the relationship between RFI and expression of lipid 
      metabolism-related genes is unknown in meat-type ducks. To address this issue, a 
      total of 1,000 male meat-type ducks with similar body weight were randomly 
      selected to measure body weight gain and feed intake from 21 to 42 d of age to 
      estimate RFI. The 8 greatest- (high RFI [HRFI]) and lowest- (low RFI [LRFI]) 
      ranking birds were then selected for the present study. Relative expressions of 
      key genes, namely sirtuin 1 (Sirt1), forkhead box O1 (Foxo1), peroxisome 
      proliferator-activated receptor gamma (PPARgamma), sterol regulatory element-binding 
      transcription factor 1c (SREBP-1c), fas cell surface death receptor (FAS), 
      acetyl-CoA carboxylase alpha (ACC), carnitine palmitoyltransferase 1A (CPT1A), 
      and acyl-CoA oxidase 1 (ACOX1), were then determined in the HRFI and LRFI ducks 
      by quantitative PCR. The results showed that RFI, feed conversion ratio (FCR), 
      and average daily feed intake (ADFI) were significantly lower (P < 0.05) in LRFI 
      ducks than in HRFI ducks. In addition, expression of Sirt1, Foxo1, CPT1A, and 
      ACOX1 were significantly higher in LRFI ducks than in HRFI ducks (P < 0.05), 
      whereas PPARgamma and FAS expression levels were significantly lower in LRFI ducks 
      than in HRFI ducks (P < 0.01). Correlation analysis showed that Sirt1, CPT1A, and 
      ACOX1 expressions were significantly negatively correlated with FCR (r = -0.81 to 
      -0.93; P < 0.01), whereas PPARgamma and FAS expressions were significantly positively 
      correlated with FCR (r = 0.74 to 0.87; P < 0.01). PPARgamma expression was 
      significantly positively correlated with RFI (r = 0.83; P < 0.01), whereas CPT1A 
      and ACOX1 expressions were significantly negatively correlated with RFI (r = 
      -0.84 to -0.89; P < 0.01). Sirt1 mRNA expression was positively correlated with 
      Foxo1, CPT1A, and ACOX1 mRNA expression (r = 0.78 to 0.92; P < 0.01). Association 
      of Foxo1 with CPT1A and ACOX1 was positive (r = 0.88 to 0.96; P < 0.01). These 
      results suggest that genes related to fatty acid oxidation are upregulated in the 
      liver of ducks with high feed efficiency, while genes associated with lipid 
      synthesis are downregulated. Furthermore, the inclusion of lipid 
      metabolism-related genes in future breeding programs might be beneficial for 
      selecting ducks with greater feed efficiency phenotype.
CI  - (c) The Author(s) 2019. Published by Oxford University Press on behalf of the 
      American Society of Animal Science. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Jin, Sihua
AU  - Jin S
AD  - College of Animal Science and Technology, Anhui Agricultural University, Hefei, 
      China.
FAU - Yang, Lei
AU  - Yang L
AD  - College of Animal Science and Technology, Anhui Agricultural University, Hefei, 
      China.
FAU - Fan, Xinfeng
AU  - Fan X
AD  - College of Animal Science and Technology, Anhui Agricultural University, Hefei, 
      China.
FAU - Wu, Minghui
AU  - Wu M
AD  - College of Animal Science and Technology, Anhui Agricultural University, Hefei, 
      China.
FAU - Xu, Yuan
AU  - Xu Y
AD  - College of Animal Science and Technology, Anhui Agricultural University, Hefei, 
      China.
FAU - Chen, Xianzen
AU  - Chen X
AD  - Anhui Provincial Key Laboratory of Local Animal Genetic Resources Conservation 
      and Biobreeding, Hefei, China.
FAU - Lin, Zhiqiang
AU  - Lin Z
AD  - Huangshan Qiangying Duck Breeding Co. Ltd., Huangshan, China.
FAU - Geng, Zhaoyu
AU  - Geng Z
AD  - College of Animal Science and Technology, Anhui Agricultural University, Hefei, 
      China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
RN  - 0 (Fatty Acids)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Animal Feed/*analysis
MH  - Animals
MH  - Body Weight/genetics
MH  - Breeding
MH  - Ducks/*genetics/physiology
MH  - Eating/*genetics
MH  - Fatty Acids/metabolism
MH  - Gene Expression Regulation/*genetics
MH  - Genetic Markers/genetics
MH  - Lipid Metabolism/*genetics
MH  - Liver/metabolism
MH  - Male
MH  - Oxidation-Reduction
MH  - Phenotype
MH  - Red Meat/*analysis
PMC - PMC6735845
OTO - NOTNLM
OT  - association
OT  - gene expression
OT  - lipid metabolism
OT  - meat-type ducks
OT  - residual feed intake
EDAT- 2019/07/22 06:00
MHDA- 2019/12/18 06:00
PMCR- 2020/09/03
CRDT- 2019/07/21 06:00
PHST- 2019/04/20 00:00 [received]
PHST- 2019/07/17 00:00 [accepted]
PHST- 2019/07/22 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/07/21 06:00 [entrez]
PHST- 2020/09/03 00:00 [pmc-release]
AID - 5536613 [pii]
AID - skz241 [pii]
AID - 10.1093/jas/skz241 [doi]
PST - ppublish
SO  - J Anim Sci. 2019 Sep 3;97(9):3947-3957. doi: 10.1093/jas/skz241.