PMID- 31325470
OWN - NLM
STAT- MEDLINE
DCOM- 20200826
LR  - 20200826
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 95
DP  - 2019 Dec 20
TI  - Nutrition and frailty: Current knowledge.
PG  - 109703
LID - S0278-5846(19)30179-4 [pii]
LID - 10.1016/j.pnpbp.2019.109703 [doi]
AB  - PURPOSE OF THE REVIEW: Nutrition, as part of lifestyle and modifiable 
      environmental factors, constitutes an interesting approach for the prevention of 
      geriatric syndromes. The objective of this review was to examine the most recent 
      evidence on the association between nutrition, from dietary patterns to specific 
      nutrients, and frailty, before the onset of disability, among elderly 
      individuals. RECENT FINDINGS: Based on available epidemiological studies, three 
      meta-analyses published in 2018 have outlined a protective effect of greater 
      adherence to a Mediterranean-type diet (MeDi) on the risk for frailty, with up to 
      a 60% reduction in risk. Several studies focusing on particular food groups, 
      macronutrients and micronutrients have also been published and have highlighted 
      that a protein intake of 1 g/kg in body weight per day should be fulfilled 
      (except for patients suffering from kidney or hepatic dysfunction) and that 
      vitamin deficiencies should be avoided. Available interventional studies of 
      nutritional supplements and/or physical activity programs have mainly been 
      limited to disabled participants to date. SUMMARY: Research efforts should target 
      both developing a better understanding of the mechanisms underlying frailty and 
      improving detection tools and the effectiveness of intervention studies, 
      alongside efforts to address the specific needs of older people. For instance, 
      ensuring an adequate nutritional status, by fighting the age-related increased 
      prevalence of undernutrition or sarcopenic obesity, should be privileged.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Feart, Catherine
AU  - Feart C
AD  - Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, team Lifelong 
      Exposure Health and Aging, U1219, F-33000 Bordeaux, France. Electronic address: 
      catherine.feart-couret@u-bordeaux.fr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190717
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*physiology
MH  - Body Weight/*physiology
MH  - Frailty/*physiopathology
MH  - Humans
MH  - *Nutritional Status
OTO - NOTNLM
OT  - Mediterranean diet
OT  - aging
OT  - frailty
OT  - nutrition
OT  - vitamins
EDAT- 2019/07/22 06:00
MHDA- 2020/08/28 06:00
CRDT- 2019/07/21 06:00
PHST- 2019/03/01 00:00 [received]
PHST- 2019/05/29 00:00 [revised]
PHST- 2019/07/16 00:00 [accepted]
PHST- 2019/07/22 06:00 [pubmed]
PHST- 2020/08/28 06:00 [medline]
PHST- 2019/07/21 06:00 [entrez]
AID - S0278-5846(19)30179-4 [pii]
AID - 10.1016/j.pnpbp.2019.109703 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2019 Dec 20;95:109703. doi: 
      10.1016/j.pnpbp.2019.109703. Epub 2019 Jul 17.