PMID- 31325539
OWN - NLM
STAT- MEDLINE
DCOM- 20191127
LR  - 20191127
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 155
DP  - 2019 Sep
TI  - Cardio-ankle vascular index is associated with diabetic retinopathy in younger 
      than 70 years patients with type 2 diabetes mellitus.
PG  - 107793
LID - S0168-8227(19)30618-7 [pii]
LID - 10.1016/j.diabres.2019.107793 [doi]
AB  - AIMS: This study aimed to investigate the relationship between cardio-ankle 
      vascular index (CAVI) and diabetic retinopathy (DR) in Caucasian patients with 
      type 2 Diabetes Mellitus (T2DM). METHODS: This was a cross-sectional study of 299 
      T2DM patients admitted to Endocrine Unit of Foggia. DR was diagnosed using the 
      International Clinical Disease Severity Scale of American Academy of 
      Ophthalmology. The VaSera VS-1500N was used to measure CAVI. Because age is the 
      most powerful determinant of arterial stiffness and affects the progression of 
      DR, we divided the whole sample into two subgroups: above (older) and below 
      (younger) 70 years. RESULTS: The mean age of patients was 60.4 +/- 12.6 years and 
      the mean CAVI value was 8.6 +/- 1.7. In the whole population DR was diagnosed in 74 
      (24.7%) patients. CAVI value was clearly higher in patients with DR (9.5 +/- 1.6) 
      than in those without (8.7 +/- 1.7) (P = 0.001) although this difference was not 
      any more significant when adjusted by age and gender (P = 0.067). In the 
      multivariate model taking into account several possible confounders, the 
      correlation between DR and CAVI remained significant only in younger subjects. In 
      the same subgroup we found a significant association between the stages of DR and 
      CAVI (p = 0.019 adjusted by age and gender). CONCLUSIONS: This study shows that 
      CAVI is significantly higher in younger patients with DR than in those without, 
      with a relationship between the stages of DR and CAVI in the same subgroup. 
      Physicians should pay attention to sub-clinical macroangiopathy in younger T2DM 
      patients who have DR.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Lamacchia, Olga
AU  - Lamacchia O
AD  - Unit of Endocrinology and Diabetology, Department of Medical and Surgical 
      Sciences, University of Foggia, via Luigi Pinto, 1, Foggia, Italy. Electronic 
      address: olga.lamacchia@unifg.it.
FAU - Sorrentino, Maria Rosaria
AU  - Sorrentino MR
AD  - Unit of Endocrinology and Diabetology, Department of Medical and Surgical 
      Sciences, University of Foggia, via Luigi Pinto, 1, Foggia, Italy.
FAU - Picca, Giuseppe
AU  - Picca G
AD  - Unit of Endocrinology and Diabetology, Department of Medical and Surgical 
      Sciences, University of Foggia, via Luigi Pinto, 1, Foggia, Italy.
FAU - Paradiso, Matteo
AU  - Paradiso M
AD  - Unit of Endocrinology and Diabetology, Department of Medical and Surgical 
      Sciences, University of Foggia, via Luigi Pinto, 1, Foggia, Italy.
FAU - Maiellaro, Pasquale
AU  - Maiellaro P
AD  - Unit of Endocrinology and Diabetology, Department of Medical and Surgical 
      Sciences, University of Foggia, via Luigi Pinto, 1, Foggia, Italy.
FAU - De Cosmo, Salvatore
AU  - De Cosmo S
AD  - Department of Medical Sciences, Scientific Institute "Casa Sollievo della 
      Sofferenza", viale Cappuccini 1, San Giovanni Rotondo (FG), Italy.
LA  - eng
PT  - Journal Article
DEP - 20190717
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Aged
MH  - Ankle/*blood supply
MH  - *Ankle Brachial Index
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Retinopathy/*diagnosis/etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - *Vascular Stiffness
OTO - NOTNLM
OT  - Arterial stiffness
OT  - Cardio-ankle vascular index
OT  - Diabetic retinopathy
OT  - Type 2 diabetes mellitus
EDAT- 2019/07/22 06:00
MHDA- 2019/11/28 06:00
CRDT- 2019/07/21 06:00
PHST- 2019/05/06 00:00 [received]
PHST- 2019/07/08 00:00 [accepted]
PHST- 2019/07/22 06:00 [pubmed]
PHST- 2019/11/28 06:00 [medline]
PHST- 2019/07/21 06:00 [entrez]
AID - S0168-8227(19)30618-7 [pii]
AID - 10.1016/j.diabres.2019.107793 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2019 Sep;155:107793. doi: 10.1016/j.diabres.2019.107793. 
      Epub 2019 Jul 17.