PMID- 31325604
OWN - NLM
STAT- MEDLINE
DCOM- 20200205
LR  - 20200205
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 243
DP  - 2019 Oct 28
TI  - Integrative Chinese herbal medicine therapy reduced the risk of type 2 diabetes 
      mellitus in patients with polycystic ovary syndrome: A nationwide matched cohort 
      study.
PG  - 112091
LID - S0378-8741(19)30615-4 [pii]
LID - 10.1016/j.jep.2019.112091 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Polycystic ovary syndrome (PCOS) is a common 
      condition that affects 5%-10% of women of reproductive age worldwide. Patients 
      with PCOS have a high degree of insulin resistance and are at an increased risk 
      of developing type 2 diabetes mellitus (T2DM). The currently available 
      therapeutic approaches for PCOS mainly focus on symptomatic treatment. AIM OF THE 
      STUDY: This study aimed to determine whether Chinese herbal medicine (CMH)-based 
      interventions could reduce the risk of T2DM in PCOS patients. MATERIALS AND 
      METHODS: This retrospective study randomly selected 1 million enrollees from the 
      National Health Insurance Database and identified 3797 patients who were newly 
      diagnosed with PCOS in 1997-2010. After 1:1 frequency-matched by age, diagnosis 
      of PCOS year and index days, we selected 342 eligible patients in each group. 
      RESULTS: The incidence of T2DM in the CHM group was significantly lower than that 
      in the non-CHM group (hazard ratio = 0.31; 95% confidence interval, 0.15-0.64; 
      p = 0.0014) after a mean follow-up period of 5.2 years (4.20 years for the 
      comparison cohort). Five herbal formulas and two single herbs showed protective 
      effects, and Paeonia lactiflora was a common ingredient in the five formulas. 
      CONCLUSIONS: Thus, CHM may help prevent T2DM-related complications in patients 
      with PCOS. Further clinical and pharmacological analysis based on these findings 
      is expected in the future.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Liao, Wan-Ting
AU  - Liao WT
AD  - Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of 
      Chinese Medicine, China Medical University, Taichung, 404, Taiwan; Department of 
      Chinese Medicine, Show Chwan Memorial Hospital, Changhua, 500, Taiwan. Electronic 
      address: enolainsky@gmail.com.
FAU - Su, Cheng-Chiung
AU  - Su CC
AD  - Post Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung, 807, 
      Taiwan. Electronic address: yakultaxel@gmail.com.
FAU - Lee, Ming-Tsung
AU  - Lee MT
AD  - Research Assistant Center, Show Chwan Memorial Hospital, Changhua, 500, Taiwan. 
      Electronic address: lee6717kimo@yahoo.com.tw.
FAU - Li, Chia-Jung
AU  - Li CJ
AD  - Research Assistant Center, Show Chwan Memorial Hospital, Changhua, 500, Taiwan. 
      Electronic address: nigel6761@gmail.com.
FAU - Lin, Cheng-Li
AU  - Lin CL
AD  - Management Office for Health Data, China Medical University Hospital, Taichung, 
      404, Taiwan. Electronic address: orangechengli@gmail.com.
FAU - Chiang, Jen-Huai
AU  - Chiang JH
AD  - Management Office for Health Data, China Medical University Hospital, Taichung, 
      404, Taiwan; College of Medicine, China Medical University, Taichung, 404, 
      Taiwan. Electronic address: zinvii@gmail.com.
FAU - Yen, Hung-Rong
AU  - Yen HR
AD  - Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of 
      Chinese Medicine, China Medical University, Taichung, 404, Taiwan; Department of 
      Chinese Medicine, China Medical University Hospital, Taichung, 404, Taiwan; 
      Research Center for Traditional Chinese Medicine, Department of Medical Research, 
      China Medical University Hospital, Taichung, 404, Taiwan; Research Center for 
      Chinese Herbal Medicine, China Medical University, Taichung, 404, Taiwan; Chinese 
      Medicine Research Center, China Medical University, Taichung, 404, Taiwan; 
      Department of Biotechnology, Asia University, Taichung, 413, Taiwan. Electronic 
      address: hungrongyen@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20190717
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/epidemiology/*prevention & control
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Female
MH  - Humans
MH  - Polycystic Ovary Syndrome/*drug therapy/epidemiology
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - National health insurance research database
OT  - Polycystic ovary syndrome
OT  - Traditional Chinese medicine
OT  - Type 2 diabetes mellitus
EDAT- 2019/07/22 06:00
MHDA- 2020/02/06 06:00
CRDT- 2019/07/21 06:00
PHST- 2019/02/14 00:00 [received]
PHST- 2019/07/03 00:00 [revised]
PHST- 2019/07/13 00:00 [accepted]
PHST- 2019/07/22 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
PHST- 2019/07/21 06:00 [entrez]
AID - S0378-8741(19)30615-4 [pii]
AID - 10.1016/j.jep.2019.112091 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2019 Oct 28;243:112091. doi: 10.1016/j.jep.2019.112091. Epub 
      2019 Jul 17.