PMID- 31326457
OWN - NLM
STAT- MEDLINE
DCOM- 20191206
LR  - 20191217
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 155
DP  - 2019 Sep
TI  - Decreasing incidence of pharmacologically treated Type 2 diabetes in Hungary from 
      2001 to 2016: A nationwide cohort study.
PG  - 107788
LID - S0168-8227(19)30359-6 [pii]
LID - 10.1016/j.diabres.2019.107788 [doi]
AB  - AIMS: Incidence and prevalence of Type 2 diabetes mellitus (T2DM) vary in 
      different regions. Long-term nationwide epidemiological data are useful to assess 
      trends over time. The aim of the study was to analyze the epidemiological changes 
      of pharmacologically treated T2DM among people aged over 18 years in Hungary 
      between 2001 and 2016. METHODS: Annual incidence, prevalence and all-cause 
      mortality rate of pharmacologically treated T2DM patients were evaluated from 
      2001 to 2016 using the central database of the National Institute of Health 
      Insurance Fund Management. Data were adjusted to age using the 2013 European 
      Standard Population. RESULTS: Incident rate of pharmacologically treated T2DM 
      decreased from 931.6 cases/100,000 person-years to 350.7 cases/100,000 
      person-years resulting in a -62.4% change (annual average change: -6.46% [95% CI: 
      -7.64%; -5.67%]) between 2001 and 2016. The prevalence rate continuously 
      increased from 4949.9 cases/100,000 persons in 2001 to the highest rate (8135.0 
      cases/100,000 persons) in 2011, which plateaued during the next 3 years and 
      slightly decreased thereafter. Standardized all-cause mortality rate in people 
      with T2DM decreased between 2001 and 2016 by 11.9% (annual average change: -0.84% 
      [95% CI: -1.22%; -0.39%]). CONCLUSIONS: Despite a clearly decreasing incidence of 
      pharmacologically treated T2DM in patients aged over 18 years, the prevalence 
      rate increased from 2001 to 2011 followed by a 3-year-long plateau and a slight 
      decrease thereafter. These long-term trends with the reduced mortality rate may 
      indicate favorable effects of health promotional activities for preventing and 
      treating T2DM.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Jermendy, Gyorgy
AU  - Jermendy G
AD  - Bajcsy-Zsilinszky Hospital, Maglodi ut 89-91, 1106 Budapest, Hungary. Electronic 
      address: gyjermendy@bajcsy.hu.
FAU - Kiss, Zoltan
AU  - Kiss Z
AD  - University of Pecs, Faculty of Medicine, 2nd Department of Medicine and 
      Nephrologica1 Center, Pacsirta ut 1, 7624 Pecs, Hungary.
FAU - Rokszin, Gyorgy
AU  - Rokszin G
AD  - RxTarget Ltd., Bacso Nandor ut 10, 5000 Szolnok, Hungary. Electronic address: 
      rokszin.gyorgy@rxtarget.hu.
FAU - Abonyi-Toth, Zsolt
AU  - Abonyi-Toth Z
AD  - RxTarget Ltd., Bacso Nandor ut 10, 5000 Szolnok, Hungary. Electronic address: 
      abonyi-toth.zsolt@rxtarget.hu.
FAU - Wittmann, Istvan
AU  - Wittmann I
AD  - University of Pecs, Faculty of Medicine, 2nd Department of Medicine and 
      Nephrologica1 Center, Pacsirta ut 1, 7624 Pecs, Hungary. Electronic address: 
      istvan.wittmann@aok.pte.hu.
FAU - Kempler, Peter
AU  - Kempler P
AD  - Semmelweis University, Faculty of Medicine, 1st Department of Medicine, Koranyi 
      Sandor ut 2, 1083 Budapest, Hungary. Electronic address: 
      kempler.peter@med.semmelweis-univ.hu.
LA  - eng
PT  - Journal Article
DEP - 20190719
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Databases, Factual
MH  - Diabetes Mellitus, Type 2/*drug therapy/epidemiology/*mortality
MH  - Female
MH  - Humans
MH  - Hungary/epidemiology
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Young Adult
OTO - NOTNLM
OT  - Health promotion activities
OT  - Incidence
OT  - Mortality
OT  - Prevalence
OT  - Type 2 diabetes
EDAT- 2019/07/22 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/07/22 06:00
PHST- 2019/03/19 00:00 [received]
PHST- 2019/06/17 00:00 [revised]
PHST- 2019/07/08 00:00 [accepted]
PHST- 2019/07/22 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/07/22 06:00 [entrez]
AID - S0168-8227(19)30359-6 [pii]
AID - 10.1016/j.diabres.2019.107788 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2019 Sep;155:107788. doi: 10.1016/j.diabres.2019.107788. 
      Epub 2019 Jul 19.