PMID- 31326514
OWN - NLM
STAT- MEDLINE
DCOM- 20200828
LR  - 20201220
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 95
DP  - 2019 Dec 20
TI  - Examination of pain threshold and neuropeptides in patients with acute suicide 
      risk.
PG  - 109705
LID - S0278-5846(19)30255-6 [pii]
LID - 10.1016/j.pnpbp.2019.109705 [doi]
AB  - INTRODUCTION: One of the main challenges in suicide prevention is the limited 
      understanding of the biological mechanisms underlying suicide. Recent findings 
      suggest impairments in pain processing in acutely suicidal patients. However, 
      little is known about the biological factors that may drive these discrete 
      physiological abnormalities. In this study, we examined plasma peptides involved 
      in analgesic and inflammatory responses and physical pain threshold in acutely 
      suicidal patients. METHODS: Thirty-seven depressed patients of both sexes 
      hospitalized for severe suicidal ideation or a recent suicide attempt were 
      characterized clinically including history of suicidal ideation and behavior. 
      Psychological and physical pain, and pressure pain threshold was also measured. 
      Plasma levels of beta-endorphin, neurotensin, agouti-related protein (AgRP), 
      C-reactive protein (CRP), adrenocorticotropic hormone (ACTH), and brain-derived 
      neurotrophic factor (BDNF) were run in Milliplex multiplex assays. RESULTS: The 
      number of lifetime suicide attempts was positively correlated with beta-endorphin 
      (r = 0.702; p = 0.007), and neurotensin (r = 0.728, p = 0.007) plasma levels. 
      Higher pain threshold was measured in the suicide attempt group as compared to 
      the suicidal ideation group. Pain threshold was strongly and negatively 
      associated with CRP plasma levels (r = -0.548; p < 0.001). In patients reporting 
      chronic pain, lower AgRP levels and lower pain threshold were observed 
      (t = 4.472; p = 0.001). CONCLUSION: Our results suggest that abnormalities in the 
      opioid and neurotensin systems may underlie the increase in pain threshold found 
      in suicide attempters, and possibly risk for suicidal behavior. Targeting pain 
      circuits and systems may provide therapeutic mechanisms for suicide prevention.
CI  - Published by Elsevier Inc.
FAU - Kim, Diane J
AU  - Kim DJ
AD  - Department of Psychiatry and Behavioral Health, Stony Brook University, Stony 
      Brook, New York, USA.
FAU - Blossom, Sarah J
AU  - Blossom SJ
AD  - Department of Pediatrics and Microbiology/Immunology, University of Arkansas for 
      Medical Sciences, Arkansas Children's Research Institute, Little Rock, AR, USA.
FAU - Delgado, Pedro L
AU  - Delgado PL
AD  - Psychiatric Research Institute, University of Arkansas for Medical Sciences, 
      Little Rock, AR, USA.
FAU - Carbajal, Jessica M
AU  - Carbajal JM
AD  - Department of Psychiatry and Behavioral Health, Stony Brook University, Stony 
      Brook, New York, USA.
FAU - Caceda, Ricardo
AU  - Caceda R
AD  - Department of Psychiatry and Behavioral Health, Stony Brook University, Stony 
      Brook, New York, USA. Electronic address: ricardo.caceda@stonybrookmedicine.edu.
LA  - eng
GR  - P01 AG012411/AG/NIA NIH HHS/United States
GR  - P30 GM110702/GM/NIGMS NIH HHS/United States
GR  - UL1 TR000039/TR/NCATS NIH HHS/United States
GR  - UL1 TR003107/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190719
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 39379-15-2 (Neurotensin)
RN  - 60617-12-1 (beta-Endorphin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Depressive Disorder/blood/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neurotensin/*blood
MH  - Pain Measurement
MH  - Pain Threshold/*physiology
MH  - *Suicidal Ideation
MH  - *Suicide, Attempted
MH  - Young Adult
MH  - beta-Endorphin/*blood
PMC - PMC7309511
MID - NIHMS1599274
OTO - NOTNLM
OT  - Analgesia
OT  - Endorphin
OT  - Neurotensin
OT  - Pain threshold
OT  - Peptides
OT  - Suicide
EDAT- 2019/07/22 06:00
MHDA- 2020/08/29 06:00
PMCR- 2020/12/20
CRDT- 2019/07/22 06:00
PHST- 2019/03/27 00:00 [received]
PHST- 2019/07/08 00:00 [revised]
PHST- 2019/07/17 00:00 [accepted]
PHST- 2019/07/22 06:00 [pubmed]
PHST- 2020/08/29 06:00 [medline]
PHST- 2019/07/22 06:00 [entrez]
PHST- 2020/12/20 00:00 [pmc-release]
AID - S0278-5846(19)30255-6 [pii]
AID - 10.1016/j.pnpbp.2019.109705 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2019 Dec 20;95:109705. doi: 
      10.1016/j.pnpbp.2019.109705. Epub 2019 Jul 19.