PMID- 31326802
OWN - NLM
STAT- MEDLINE
DCOM- 20190919
LR  - 20210110
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Print)
IS  - 0048-9697 (Linking)
VI  - 691
DP  - 2019 Nov 15
TI  - Concentrations of organohalogens (PCBs, DDTs, PBDEs) in hunted and stranded 
      Northern sea otters (Enhydra lutris kenyoni) in Alaska from 1992 to 2010: Links 
      to pathology and feeding ecology.
PG  - 789-798
LID - S0048-9697(19)33153-5 [pii]
LID - 10.1016/j.scitotenv.2019.07.040 [doi]
AB  - Many organohalogen compounds (OHCs) are persistent organic pollutants (POPs) 
      found in appreciable concentrations in marine predators. While production of some 
      POPs has declined or ceased in recent decades, their capacity for global 
      transport and bioaccumulation results in observations of unchanging or increasing 
      concentrations in marine systems. Sea otters (Enhydra lutris) have been advocated 
      as an environmental sentinel for contaminants due to their longevity, site 
      fidelity and prey species that often overlap with human consumption. Using 
      archived (1992-2010) samples of livers from Northern sea otters (n = 50) from 
      Alaska we examine concentrations of chlordanes (CHLs), polychlorinated biphenyls 
      (PCBs), dichlorodiphenyltrichloroethane (DDTs), and polybrominated diphenyl 
      ethers (PBDEs) and associated metabolites. We found some evidence for declining 
      SigmaPCBs over the two decades, however for most animals concentrations were low 
      compared to toxicological thresholds. Six animals had relatively high 
      concentrations of SigmaPCBs (mean = 262,000 ng/g lipid weight), SigmaDDTs 
      (mean = 8,800 ng/g lw), and SigmaPBDEs (mean = 4,600 ng/g lw), with four of these six 
      animals experiencing hepatic parasitism or hepatitis. In order to assess whether 
      differences in POP concentrations are associated with feeding ecology, we 
      examined stable isotopes of C and N in archived muscle and whisker samples. In 
      general, there were no significant relationships between SigmaPOP concentrations and 
      stable isotope ratios. There were small differences in stable isotope profiles in 
      animals with high POP concentrations, although it was unclear if these 
      differences were due to feeding ecology or disease processes. This study 
      highlights the importance of considering feeding ecology and necropsy (health and 
      disease status) data while conducting contaminant surveys, and confirms some 
      previous reports of trends in OHCs in Alaska marine mammals.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Harley, John R
AU  - Harley JR
AD  - Alaska Coastal Rainforest Center, University of Alaska Southeast, 11066 Auke Lake 
      Way, Juneau, AK 99801, USA. Electronic address: john.harley@alaska.edu.
FAU - Gill, Verena A
AU  - Gill VA
AD  - United States Fish and Wildlife Service, Marine Mammals Management, 1011 East 
      Tudor Road, MS 341, Anchorage, AK 99503, USA; National Oceanic and Atmospheric 
      Administration Fisheries, 222 W. 7th Ave, Rm 552, Anchorage, AK 99513, USA.
FAU - Lee, Sunmi
AU  - Lee S
AD  - Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA; 
      School of Public Health, State University of New York, Albany, NY 12201, USA.
FAU - Kannan, Kurunthachalam
AU  - Kannan K
AD  - Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA; 
      School of Public Health, State University of New York, Albany, NY 12201, USA.
FAU - Santana, Vanessa
AU  - Santana V
AD  - Department of Biology and Wildlife, University of Alaska, Fairbanks, 982 Koyukuk 
      Dr, Fairbanks, AK 99775-7750, USA.
FAU - Burek-Huntington, Kathy
AU  - Burek-Huntington K
AD  - Alaska Veterinary Pathology Services, 23834 The Clearing Drive, Eagle River, AK 
      99577, USA.
FAU - O'Hara, Todd M
AU  - O'Hara TM
AD  - Department of Veterinary Medicine, University of Alaska, Fairbanks, 901 Koyukuk 
      Dr, Fairbanks, AK 99775-7750, USA.
LA  - eng
GR  - P30 AR070549/AR/NIAMS NIH HHS/United States
GR  - RL5 GM118990/GM/NIGMS NIH HHS/United States
GR  - TL4 GM118992/GM/NIGMS NIH HHS/United States
GR  - UL1 GM118991/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20190704
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Water Pollutants, Chemical)
RN  - CIW5S16655 (DDT)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Alaska
MH  - Animals
MH  - DDT/metabolism
MH  - Ecology
MH  - *Environmental Monitoring
MH  - Halogenated Diphenyl Ethers/metabolism
MH  - Hydrocarbons, Chlorinated/*metabolism
MH  - Otters/*metabolism
MH  - Polychlorinated Biphenyls/metabolism
MH  - Water Pollutants, Chemical/*metabolism
PMC - PMC6711818
MID - NIHMS1535703
OTO - NOTNLM
OT  - Alaska
OT  - Contaminants
OT  - PBDEs
OT  - PCBs
OT  - POPs
OT  - Sea otters
EDAT- 2019/07/22 06:00
MHDA- 2019/09/20 06:00
PMCR- 2020/11/15
CRDT- 2019/07/22 06:00
PHST- 2019/04/04 00:00 [received]
PHST- 2019/07/02 00:00 [revised]
PHST- 2019/07/03 00:00 [accepted]
PHST- 2019/07/22 06:00 [pubmed]
PHST- 2019/09/20 06:00 [medline]
PHST- 2019/07/22 06:00 [entrez]
PHST- 2020/11/15 00:00 [pmc-release]
AID - S0048-9697(19)33153-5 [pii]
AID - 10.1016/j.scitotenv.2019.07.040 [doi]
PST - ppublish
SO  - Sci Total Environ. 2019 Nov 15;691:789-798. doi: 10.1016/j.scitotenv.2019.07.040. 
      Epub 2019 Jul 4.