PMID- 31327579
OWN - NLM
STAT- MEDLINE
DCOM- 20200213
LR  - 20200213
IS  - 1532-818X (Electronic)
IS  - 0196-0709 (Linking)
VI  - 40
IP  - 5
DP  - 2019 Sep-Oct
TI  - Efficacy and safety of sublingual dust mite drops in children with mono- or 
      polysensitized allergic rhinitis.
PG  - 755-760
LID - S0196-0709(19)30413-2 [pii]
LID - 10.1016/j.amjoto.2019.07.010 [doi]
AB  - OBJECTIVE: To explore the efficacy and safety of sublingual house dust mite (HDM) 
      drops in children with mono- or polysensitized allergic rhinitis. METHODS: We 
      conducted a retrospective cohort study of 65 children with monosensitized AR and 
      118 children with polysensitized AR who were scheduled for sublingual 
      administration of HDM drops from January 2015 to June 2016. Interleukin (IL)-2, 
      IL-4, and IL-17alpha, transforming growth factor-beta1 (TGF-beta1), specific immunoglobulin 
      E (IgE), and specific IgG4 were detected by ELISA. The efficacies were assessed 
      using symptoms score and medication score. All the outcomes were measured 1 month 
      before the study and 1 month after the end of the 2-year treatment. RESULTS: The 
      total nasal symptoms score (TNSS) decreased significantly from 11.27 
      (9.81 +/- 12.73) at baseline to 3.48(1.98 +/- 4.98) at the end of sublingual 
      treatment for the monosensitized AP group (t = 30.00, P < 0.01), and from 
      11.54(10.04 +/- 13.04) to 3.56 (2.00 +/- 5.16) for the polysensitized AR group 
      (t = 40.05, P < 0.01), respectively. IL-2 and TGF-beta1 increased significantly 
      after treatment in contrast with before treatment in both the monosensitized 
      group and the polysensitized group (both P < 0.01). In contrast, IL-4 and IL-17alpha 
      decreased significantly after treatment compared with the baseline in both groups 
      (both P < 0.01). Sublingual HDM drops were generally safe and well tolerant in 
      both groups. CONCLUSIONS: This study confirmed the efficacy and safety of 
      sublingual AIT in both monosensitized and polysensitized AR patients (Chinese 
      children).
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Zhang, Yao-Zu
AU  - Zhang YZ
AD  - Department of Otolaryngology-Head and Neck Surgery, The Affiliated Children 
      Hospital of Xi'an Jiao Tong University, Shanxi, Xi'an 710003, China.
FAU - Luo, Juan
AU  - Luo J
AD  - Department of Otolaryngology-Head and Neck Surgery, The Affiliated Children 
      Hospital of Xi'an Jiao Tong University, Shanxi, Xi'an 710003, China.
FAU - Wang, Zi-Han
AU  - Wang ZH
AD  - Department of Otolaryngology-Head and Neck Surgery, The Affiliated Children 
      Hospital of Xi'an Jiao Tong University, Shanxi, Xi'an 710003, China.
FAU - Wang, Jie
AU  - Wang J
AD  - Department of Otolaryngology-Head and Neck Surgery, The Affiliated Children 
      Hospital of Xi'an Jiao Tong University, Shanxi, Xi'an 710003, China. Electronic 
      address: wangjie0112@icloud.com.
LA  - eng
PT  - Journal Article
DEP - 20190716
PL  - United States
TA  - Am J Otolaryngol
JT  - American journal of otolaryngology
JID - 8000029
SB  - IM
MH  - Administration, Sublingual
MH  - Adolescent
MH  - Animals
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Databases, Factual
MH  - Dermatophagoides farinae/*immunology
MH  - Female
MH  - Humans
MH  - Immunization
MH  - Immunotherapy/adverse effects/*methods
MH  - Male
MH  - Patient Safety
MH  - Prognosis
MH  - Pyroglyphidae/*immunology
MH  - Retrospective Studies
MH  - Rhinitis, Allergic/diagnosis/immunology/*therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - Efficacy
OT  - House dust mite
OT  - Immunotherapy
EDAT- 2019/07/23 06:00
MHDA- 2020/02/14 06:00
CRDT- 2019/07/23 06:00
PHST- 2019/05/04 00:00 [received]
PHST- 2019/07/12 00:00 [revised]
PHST- 2019/07/16 00:00 [accepted]
PHST- 2019/07/23 06:00 [pubmed]
PHST- 2020/02/14 06:00 [medline]
PHST- 2019/07/23 06:00 [entrez]
AID - S0196-0709(19)30413-2 [pii]
AID - 10.1016/j.amjoto.2019.07.010 [doi]
PST - ppublish
SO  - Am J Otolaryngol. 2019 Sep-Oct;40(5):755-760. doi: 10.1016/j.amjoto.2019.07.010. 
      Epub 2019 Jul 16.