PMID- 3133103
OWN - NLM
STAT- MEDLINE
DCOM- 19880729
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 62
IP  - 1
DP  - 1988 Jul 1
TI  - Results of the radiotherapeutic management of carcinoma of the cervix with 
      emphasis on the influence of histologic classification.
PG  - 48-53
AB  - The histology of 365 of 396 patients (92%) treated with radiation therapy at the 
      University of Virginia from 1968 to 1978 has been reviewed. Staging and treatment 
      policies were consistent throughout this period, and have enabled the influence 
      of histologic classification on treatment results to be evaluated. Large cell 
      nonkeratinizing carcinoma (LCNK) was the most common type, 69%; followed by 
      keratinizing (KSCC), 13%; and adenocarcinoma, 6.6%. Other varieties included 
      adenosquamous, 3.6%; small cell undifferentiated carcinoma, 2.7%; papillary 
      squamous, 1.6%; and glassy cell, 1.4%. Overall survivals by stage were similar to 
      those reported from other centers. When examined by histologic type, the 5-year 
      survival rates ranged from 64% for adenosquamous to 13% for small cell. The most 
      common varieties, LCNK and KSCC, had survival rates of 61% and 40% (P = 0.008). 
      Considering both stage and histologic type, the differences between LCNK and KSCC 
      persisted and were significant for Stage IIB (P = 0.023). Of particular interest 
      are the poor results in small cell carcinoma and adenocarcinoma, except in the 
      earliest stages, and the good results for adenosquamous carcinoma. The patterns 
      of failure by histologic type showed that local failures were higher in cases of 
      KSCC than in LCNK, indicating a probable difference in radiosensitivity. Distant 
      spread was similar for both types. Both small cell carcinoma and adenocarcinoma 
      showed high rates of distant spread and local failure except in the early stages. 
      Considering survival and failure rates, three prognostic groups could be 
      identified. In descending order of curability these were: 1) LCNK and 
      adenosquamous carcinoma; 2) KSCC, papillary squamous carcinoma, and 
      adenocarcinoma; and 3) small cell carcinoma and glassy cell carcinoma.
FAU - Randall, M E
AU  - Randall ME
AD  - Division of Therapeutic Radiology and Oncology, University of Virginia Medical 
      Center, Charlottesville 22908.
FAU - Constable, W C
AU  - Constable WC
FAU - Hahn, S S
AU  - Hahn SS
FAU - Kim, J A
AU  - Kim JA
FAU - Mills, S E
AU  - Mills SE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Brachytherapy
MH  - Carcinoma, Squamous Cell/pathology/*radiotherapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Prognosis
MH  - Radiotherapy, High-Energy
MH  - Retrospective Studies
MH  - Uterine Cervical Neoplasms/pathology/*radiotherapy
EDAT- 1988/07/01 00:00
MHDA- 1988/07/01 00:01
CRDT- 1988/07/01 00:00
PHST- 1988/07/01 00:00 [pubmed]
PHST- 1988/07/01 00:01 [medline]
PHST- 1988/07/01 00:00 [entrez]
AID - 10.1002/1097-0142(19880701)62:1<48::aid-cncr2820620111>3.0.co;2-y [doi]
PST - ppublish
SO  - Cancer. 1988 Jul 1;62(1):48-53. doi: 
      10.1002/1097-0142(19880701)62:1<48::aid-cncr2820620111>3.0.co;2-y.