PMID- 31332990
OWN - NLM
STAT- MEDLINE
DCOM- 20191014
LR  - 20191014
IS  - 1827-1928 (Electronic)
IS  - 0022-4707 (Linking)
VI  - 59
IP  - 7
DP  - 2019 Jul
TI  - Circulating adiponectin expression is elevated and associated with the 
      IL-15/IL-15Ralpha complex in obese physically active humans.
PG  - 1229-1237
LID - 10.23736/S0022-4707.18.09030-8 [doi]
AB  - BACKGROUND: Adiponectin is an adipokine with oxidative, anti-inflammatory and 
      antiatherogenic effects in several peripheral tissues; however, circulating 
      adiponectin expression is reduced in cardio-metabolic diseases. The aim of this 
      study was to ascertain whether regular physical activity mediates circulating 
      adiponectin concentrations at baseline in an obese population. METHODS: Two 
      hundred and twenty-one obese participants were divided into 6 groups according to 
      gender, physical activity (PA), and type 2 diabetes mellitus (T2DM) diagnosis: A 
      and B) obese PA females (N.=28) and males (N.=33); C and D) obese non-PA females 
      (N.=40) and males (N.=40); E and F) obese non-PA females (N.=40) and males 
      (N.=40) with T2DM. Serum adiponectin, IL-15 and IL-15Ralpha, blood glucose/lipid 
      profile, and body composition were measured. RESULTS: Circulating adiponectin 
      increased in PA participants compared to non-PA (ANOVA, P=0.001), finding higher 
      concentrations in females compared to males (P<0.001), particularly in the PA 
      group (P=0.005). Serum adiponectin was associated with age (R2=0.068), body mass 
      (R2=-0.108), waist circumference (WC) (R2=-0.122), LDL (R2=-0.045), triglycerides 
      (R2=-0.043), and serum IL-15Ralpha (R2=-0.243), as well as fat mass in females 
      (R2=0.098), and WC in males (R2=0.112). CONCLUSIONS: Circulating adiponectin 
      increased in obese PA participants (>/=180 min/week) compared to non-PA 
      counterparts, indicating that physical activity may mediate baseline adiponectin 
      levels irrespective of the fat mass regulatory effect. The inverse relationship 
      found between serum adiponectin and IL-15Ralpha may support the regulative role of 
      the IL-15/IL-15Ralpha complex on this adipokine at baseline.
FAU - Perez-Lopez, Alberto
AU  - Perez-Lopez A
AD  - Department of Medicine and Medical Specialties, Faculty of Medicine and Health 
      Sciences, University of Alcala, Madrid, Spain - Alberto_perez-lopez@hotmail.com.
AD  - Biomedical Research Networking Center on Bioengineering, Biomaterials and 
      Nanomedicine (CIBER-BBN), Madrid, Spain - Alberto_perez-lopez@hotmail.com.
AD  - Department of Biomedical Sciences, Area of Sport and Physical Education, Faculty 
      of Medicine and Health Sciences, University of Alcala, Madrid, Spain - 
      Alberto_perez-lopez@hotmail.com.
FAU - Valades, David
AU  - Valades D
AD  - Department of Biomedical Sciences, Area of Sport and Physical Education, Faculty 
      of Medicine and Health Sciences, University of Alcala, Madrid, Spain.
FAU - de Cos Blanco, Ana I
AU  - de Cos Blanco AI
AD  - Department of Nutrition, Hospital Universitario La Paz, Madrid, Spain.
FAU - Garcia-Honduvilla, Natalio
AU  - Garcia-Honduvilla N
AD  - Department of Medicine and Medical Specialties, Faculty of Medicine and Health 
      Sciences, University of Alcala, Madrid, Spain.
AD  - Biomedical Research Networking Center on Bioengineering, Biomaterials and 
      Nanomedicine (CIBER-BBN), Madrid, Spain.
FAU - Vazquez Martinez, Clotilde
AU  - Vazquez Martinez C
AD  - Department of Nutrition, Hospital Universitario La Paz, Madrid, Spain.
AD  - Department of Endocrinology and Nutrition, Hospital Universitario Fundacion 
      Jimenez Diaz, Madrid, Spain.
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Sports Med Phys Fitness
JT  - The Journal of sports medicine and physical fitness
JID - 0376337
RN  - 0 (Adiponectin)
RN  - 0 (Interleukin-15)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - Body Composition
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/complications
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Interleukin-15/*blood
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood/complications
EDAT- 2019/07/25 06:00
MHDA- 2019/10/15 06:00
CRDT- 2019/07/24 06:00
PHST- 2019/07/24 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2019/10/15 06:00 [medline]
AID - S0022-4707.18.09030-8 [pii]
AID - 10.23736/S0022-4707.18.09030-8 [doi]
PST - ppublish
SO  - J Sports Med Phys Fitness. 2019 Jul;59(7):1229-1237. doi: 
      10.23736/S0022-4707.18.09030-8.