PMID- 31333320
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1016-7315 (Print)
IS  - 2212-5043 (Electronic)
IS  - 1016-7315 (Linking)
VI  - 31
IP  - 4
DP  - 2019 Oct
TI  - Safety and efficacy of off-label use of ivabradine in patients with acute heart 
      failure.
PG  - 179-187
LID - 10.1016/j.jsha.2019.05.006 [doi]
AB  - BACKGROUND: Ivabradine is approved to improve exercise tolerance and quality of 
      life in patients with chronic heart failure; its use in acute heart failure (AHF) 
      has not previously been studied. METHODS: Forty adult patients admitted with AHF 
      were randomized into two groups; Group 1 patients were prescribed beta-blockers 
      (BBs) and Group 2 patients were prescribed ivabradine. Both groups were given 
      optimum anti-failure treatment for AHF. All patients were assessed for heart rate 
      (HR), 6-minute walk test (6MWT), New York Heart Association (NYHA) 
      classification, and Minnesota Living With Heart Failure Questionnaire (MLWHFQ) 
      before and after 1 month of therapy. RESULTS: BBs or ivabradine among optimum 
      medical therapy for AHF resulted in a significant improvement in all the studied 
      parameters (NYHA class; 6MWT distance; HR and Borg scale dyspnea/fatigue score 
      before and after the walk). The MLWHFQ was significantly worse during the 
      follow-up in both groups. At the end of follow-up, there was a comparable 
      beneficial effect attributed to the significant HR reduction observed in both 
      groups. CONCLUSION: The results of this pilot study demonstrated the safety of 
      the early use of ivabradine alone versus BBs when tolerated in patients admitted 
      with AHF (both acutely decompensated as well as de novo). Both groups achieved 
      comparable reduction in HR with improvement in functional capacity and exercise 
      tolerance.
FAU - Othman, Khaled M Said
AU  - Othman KMS
AD  - Department of Cardiology, Faculty of Medicine, Ain Shams University, Cairo 
      EgyptEgypt.
FAU - Mostafa, Mohamed Ahmed Radwan
AU  - Mostafa MAR
AD  - Department of Cardiology, Faculty of Medicine, Ain Shams University, Cairo 
      EgyptEgypt.
FAU - Yosef, Ahmed Elsayed
AU  - Yosef AE
AD  - Department of Cardiology, Faculty of Medicine, Ain Shams University, Cairo 
      EgyptEgypt.
FAU - Abdeltawab, Adham Ahmed
AU  - Abdeltawab AA
AD  - Department of Cardiology, Faculty of Medicine, Ain Shams University, Cairo 
      EgyptEgypt.
LA  - eng
PT  - Journal Article
DEP - 20190612
PL  - Saudi Arabia
TA  - J Saudi Heart Assoc
JT  - Journal of the Saudi Heart Association
JID - 9887261
PMC - PMC6614597
OTO - NOTNLM
OT  - Acute heart failure
OT  - Exercise tolerance
OT  - Functional capacity
OT  - Ivabradine
EDAT- 2019/07/25 06:00
MHDA- 2019/07/25 06:01
PMCR- 2019/06/12
CRDT- 2019/07/24 06:00
PHST- 2019/03/15 00:00 [received]
PHST- 2019/05/22 00:00 [revised]
PHST- 2019/05/24 00:00 [accepted]
PHST- 2019/07/24 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2019/07/25 06:01 [medline]
PHST- 2019/06/12 00:00 [pmc-release]
AID - S1016-7315(19)30058-2 [pii]
AID - 10.1016/j.jsha.2019.05.006 [doi]
PST - ppublish
SO  - J Saudi Heart Assoc. 2019 Oct;31(4):179-187. doi: 10.1016/j.jsha.2019.05.006. 
      Epub 2019 Jun 12.