PMID- 31333344
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1642-395X (Print)
IS  - 2299-0046 (Electronic)
IS  - 1642-395X (Linking)
VI  - 36
IP  - 3
DP  - 2019 Jun
TI  - Investigation of the relationship between atopy and psoriasis.
PG  - 276-281
LID - 10.5114/ada.2019.85639 [doi]
AB  - INTRODUCTION: The relationship between allergic and autoimmune diseases is an 
      important issue, which has recently attracted the researchers' interest. AIM: To 
      determine the relationship between atopy and psoriasis. MATERIAL AND METHODS: 
      This case-control study was conducted on 102 patients referred to the Ghaem 
      Hospital, Mashhad, Iran, in 2016. The participants were assigned into two groups: 
      experimental and control groups, including the patients suffering from psoriasis 
      and those with no history of cutaneous or other systemic diseases, respectively. 
      Both groups filled in the ISAAC questionnaire and had skin prick tests. In 
      addition, the serum levels of immunoglobulin E (IgE) and blood eosinophil cell 
      count were measured. The data were analysed using the regression test through 
      SPSS version 16. RESULTS: According to the results of the ISAAC questionnaire, 
      there was a significant difference between the control and experimental groups in 
      terms of asthma (p = 0.04). The mean serum concentrations of IgE and eosinophil 
      cell count were not significantly different between the experimental (153.93 
      IU/ml and 187.77 cells/mul, respectively) and control groups (152.19 IU/ml and 
      187.68 cells/mul, respectively) (p = 0.057 and p = 0.886, respectively). In 
      addition, there was an indirect correlation between the eosinophil cell count and 
      psoriasis severity (p = 0.032, r = -0.297). Furthermore, the comparison of the 
      skin prick test results revealed no significant difference between the two groups 
      regarding the number of positive and negative cases (p = 0.436). CONCLUSIONS: The 
      findings suggested that atopy was not common in the patients with psoriasis and 
      supported the concept that atopy protects against such autoimmune diseases such 
      as psoriasis.
FAU - Hosseini, Pegah
AU  - Hosseini P
AD  - Student Research Committee, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
FAU - Khoshkhui, Maryam
AU  - Khoshkhui M
AD  - Allergy Research Center, Mashhad University of Medical sciences, Mashhad, Iran.
FAU - Hosseini, Reza Farid
AU  - Hosseini RF
AD  - Allergy Research Center, Mashhad University of Medical sciences, Mashhad, Iran.
FAU - Ahanchian, Hamid
AU  - Ahanchian H
AD  - Inflammation and Inflammatory Diseases Research Center, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
FAU - Ravanshad, Yalda
AU  - Ravanshad Y
AD  - Clinical Research Development Units, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Layegh, Pouran
AU  - Layegh P
AD  - Cutaneous Leishmaniasis Research Center, Faculty of Medicine, Mashhad University 
      of Medical Sciences, Mashhad, Iran.
FAU - Bakhshoudeh, Behnoosh
AU  - Bakhshoudeh B
AD  - Student Research Committee, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
FAU - Ariaee, Nazila
AU  - Ariaee N
AD  - Allergy Research Center, Mashhad University of Medical sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
DEP - 20190618
PL  - Poland
TA  - Postepy Dermatol Alergol
JT  - Postepy dermatologii i alergologii
JID - 101168357
PMC - PMC6640011
OTO - NOTNLM
OT  - atopy
OT  - eosinophilia
OT  - immunoglobulin E
OT  - psoriasis
COIS- The authors declare no conflict of interest.
EDAT- 2019/07/25 06:00
MHDA- 2019/07/25 06:01
PMCR- 2019/06/01
CRDT- 2019/07/24 06:00
PHST- 2018/01/13 00:00 [received]
PHST- 2018/03/16 00:00 [accepted]
PHST- 2019/07/24 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2019/07/25 06:01 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
AID - 85639 [pii]
AID - 10.5114/ada.2019.85639 [doi]
PST - ppublish
SO  - Postepy Dermatol Alergol. 2019 Jun;36(3):276-281. doi: 10.5114/ada.2019.85639. 
      Epub 2019 Jun 18.