PMID- 31333585
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200225
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 10
DP  - 2019
TI  - Risk Factors of Thyroid Dysfunction in Patients With Type 2 Diabetes Mellitus.
PG  - 440
LID - 10.3389/fendo.2019.00440 [doi]
LID - 440
AB  - Background: Thyroid dysfunction has been widely reported among persons with 
      diabetes (DM) in other parts of the World. In Nigeria, few studies have been 
      reported. This study focused on risk factors for thyroid dysfunction in type 2 
      diabetes mellitus (T2DM) patients and will therefore add to the Nigerian 
      literature, more so, as it is the first in South-East Nigeria. Objective: To 
      determine the risk factors of thyroid dysfunction in patients with Type 2 DM. 
      Methodology: Three hundred and fifty-four T2DM patients and 118 non-diabetic 
      persons (controls) were recruited for the study. A pretested questionnaire was 
      filled for each subject after due explanations. The subjects were subsequently 
      examined and the findings, including anthropometric values and clinical 
      parameters were documented. Their blood samples were tested for HbA1c, fT3, fT4, 
      and TSH. Information retrieved from patients medical records included: age at 
      diagnosis of DM, duration of DM, complications of DM. The Student's t-test, chi 
      square test and regression analysis were used in the analysis of the data 
      obtained. P < 0.05 was taken to be statistically significant. Results: About 
      56.5% of the T2DM patients who participated in this study were females and 62.7% 
      of the controls were females. The T2DM patients had significantly higher BMI than 
      controls (27.6 +/- 5.0 kg/m(2) vs. 26.2 +/- 3.8 kg/m(2), p = 0.002). Mean HbA1c was 
      significantly higher in T2DM patients than in the controls (7.8 +/- 2.0% vs. 5.8 +/- 
      1.2%, p = 0.001). Female gender (OR = 3.8, p = 0.002), central obesity (OR = 2.5, 
      95%CI = 1.5-5.2, p = 0.001), DM nephropathy (OR = 4.8, p = 0.001), HbA1c >/=7% (OR 
      = 4.3, p = 0.025) and duration of DM >5years (OR = 3.3, p = 0.012) were 
      significantly associated with thyroid dysfunction in T2DM patients in this study. 
      Conclusion: Female gender, central obesity, DM nephropathy, above normal HbA1c, 
      and duration of DM were risk factors of thyroid dysfunction in type 2 DM patients 
      in this study.
FAU - Ogbonna, Stanley U
AU  - Ogbonna SU
AD  - Department of Internal Medicine, Federal Medical Center, Umuahia, Nigeria.
FAU - Ezeani, Ignatius U
AU  - Ezeani IU
AD  - Department of Internal Medicine, Federal Medical Center, Umuahia, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20190704
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC6621929
OTO - NOTNLM
OT  - South East Nigeria
OT  - hypothyroidism
OT  - predictors
OT  - risk factors
OT  - thyroid dysfunction
OT  - type 2 diabetes mellitus
EDAT- 2019/07/25 06:00
MHDA- 2019/07/25 06:01
PMCR- 2019/01/01
CRDT- 2019/07/24 06:00
PHST- 2019/01/24 00:00 [received]
PHST- 2019/06/18 00:00 [accepted]
PHST- 2019/07/24 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2019/07/25 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2019.00440 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2019 Jul 4;10:440. doi: 10.3389/fendo.2019.00440. 
      eCollection 2019.