PMID- 31333751
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 1742-4933 (Print)
IS  - 1742-4933 (Electronic)
IS  - 1742-4933 (Linking)
VI  - 16
DP  - 2019
TI  - Inflammatory markers and bone health in postmenopausal women: a cross-sectional 
      overview.
PG  - 15
LID - 10.1186/s12979-019-0155-x [doi]
LID - 15
AB  - BACKGROUND: Cytokines, chemokines, C-reactive proteins (CRP) and ferritin are 
      known inflammatory markers. However, cytokines such as interleukin (IL-1beta), 
      (IL-6) and tumour necrosis factor (TNF-alpha) have been reported to interfere with 
      both the bone resorption and bone formation processes. Similarly, immune cell 
      cytokines are known to contribute to inflammation of the adipose tissue 
      especially with obesity. IL-10 but not IL-33 has been linked to lower ferritin 
      levels and anemia. In this study, we hypothesized that specific cytokine levels 
      in the plasma of women with low bone mineral density (BMD) would be higher than 
      those in the plasma of healthy women due to the actions of elevated levels of 
      pro-inflammatory cytokines in inducing osteoclast formation and differentiation 
      during senescence. RESULTS: Levels of cytokines (IFNalpha2, IFN-gamma, IL-12p70, IL-33) 
      and monocyte chemoattractant protein-1 (MCP-1) were significantly higher in the 
      plasma of the osteoporotic group compared to the osteopenic and/or healthy 
      groups. Meanwhile CRP levels were significantly lower in women with osteoporosis 
      (P = 0.040) than the osteopenic and healthy groups. Hip BMD values were 
      significantly lower in women with high/detectable values of IL-1beta (P = 0.020) and 
      IL-6 (P = 0.030) compared to women where these were not detected. Similarly, 
      women with high/detectable values of IL-1beta had significantly lower spine BMD than 
      those where IL-1beta was not detected (P = 0.030). Participants' CRP levels were 
      significantly positively correlated with BMI, fat mass and fat percentage 
      (P < 0.001). In addition, ferritin levels of women with high/detectable values of 
      anti-osteoclastogenic IL-10 (P = 0.012) and IL-33 (P = 0.017) were significantly 
      lower than those where these were not detected. There was no statistically 
      significant association between TNF-alpha and BMD of the hip and lumbar spine. 
      CONCLUSIONS: High levels of cytokines (IFNalpha2, IFN-gamma, IL-12p70, IL-33) and MCP-1 
      in apparently healthy postmenopausal women are associated with bone health 
      issues. In addition, an increase in levels of IL-10 and IL-33 may be associated 
      with low ferritin levels in this age group. TRIAL REGISTRATION: ANZCTR, 
      ACTRN12617000802303. Registered May 31st, 2017, 
      https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=373020.
FAU - Ilesanmi-Oyelere, Bolaji Lilian
AU  - Ilesanmi-Oyelere BL
AUID- ORCID: 0000-0003-2274-4206
AD  - 1Department of Nutritional Science, School of Food and Advanced Technology, 
      College of Sciences, Massey University, Tennent Drive, Palmerston North, 4442 New 
      Zealand. ISNI: 0000 0001 0696 9806. GRID: grid.148374.d
AD  - 2Riddet Institute, Palmerston North, 4442 New Zealand. GRID: grid.484608.6
AD  - 3Food Nutrition & Health Team, AgResearch Grasslands, Palmerston North, 4442 New 
      Zealand. ISNI: 0000 0001 2110 5328. GRID: grid.417738.e
FAU - Schollum, Linda
AU  - Schollum L
AD  - Fonterra Research and Development Centre, Palmerston North, 4472 New Zealand.
FAU - Kuhn-Sherlock, Barbara
AU  - Kuhn-Sherlock B
AD  - BKS Consulting, Hamilton, New Zealand.
FAU - McConnell, Michelle
AU  - McConnell M
AD  - 6Department of Microbiology and Immunology, University of Otago, Dunedin, 9054 
      New Zealand. ISNI: 0000 0004 1936 7830. GRID: grid.29980.3a
FAU - Mros, Sonya
AU  - Mros S
AD  - 6Department of Microbiology and Immunology, University of Otago, Dunedin, 9054 
      New Zealand. ISNI: 0000 0004 1936 7830. GRID: grid.29980.3a
FAU - Coad, Jane
AU  - Coad J
AD  - 1Department of Nutritional Science, School of Food and Advanced Technology, 
      College of Sciences, Massey University, Tennent Drive, Palmerston North, 4442 New 
      Zealand. ISNI: 0000 0001 0696 9806. GRID: grid.148374.d
FAU - Roy, Nicole C
AU  - Roy NC
AD  - 2Riddet Institute, Palmerston North, 4442 New Zealand. GRID: grid.484608.6
AD  - 3Food Nutrition & Health Team, AgResearch Grasslands, Palmerston North, 4442 New 
      Zealand. ISNI: 0000 0001 2110 5328. GRID: grid.417738.e
AD  - High-Value Nutrition National Science Challenge, Auckland, New Zealand.
FAU - Kruger, Marlena Cathorina
AU  - Kruger MC
AD  - 1Department of Nutritional Science, School of Food and Advanced Technology, 
      College of Sciences, Massey University, Tennent Drive, Palmerston North, 4442 New 
      Zealand. ISNI: 0000 0001 0696 9806. GRID: grid.148374.d
AD  - 2Riddet Institute, Palmerston North, 4442 New Zealand. GRID: grid.484608.6
AD  - 8School of Health Sciences, College of Health, Massey University, Palmerston 
      North, 4442 New Zealand. ISNI: 0000 0001 0696 9806. GRID: grid.148374.d
LA  - eng
PT  - Journal Article
DEP - 20190710
PL  - England
TA  - Immun Ageing
JT  - Immunity & ageing : I & A
JID - 101235427
PMC - PMC6621960
OTO - NOTNLM
OT  - Aging
OT  - Bone health
OT  - Bone mineral density
OT  - Chemokines
OT  - Cytokines
OT  - Ferritin
OT  - Inflammatory markers
OT  - Osteo-immunology
OT  - Postmenopausal women
COIS- Competing interestsThe authors declare that they have no competing interests.
EDAT- 2019/07/25 06:00
MHDA- 2019/07/25 06:01
PMCR- 2019/07/10
CRDT- 2019/07/24 06:00
PHST- 2019/04/19 00:00 [received]
PHST- 2019/06/28 00:00 [accepted]
PHST- 2019/07/24 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2019/07/25 06:01 [medline]
PHST- 2019/07/10 00:00 [pmc-release]
AID - 155 [pii]
AID - 10.1186/s12979-019-0155-x [doi]
PST - epublish
SO  - Immun Ageing. 2019 Jul 10;16:15. doi: 10.1186/s12979-019-0155-x. eCollection 
      2019.