PMID- 31333879
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2056-9920 (Print)
IS  - 2056-9920 (Electronic)
IS  - 2056-9920 (Linking)
VI  - 5
DP  - 2019
TI  - Choroidal thickness measured with swept source optical coherence tomography in 
      posterior staphyloma strongly correlates with axial length and visual acuity.
PG  - 14
LID - 10.1186/s40942-019-0166-y [doi]
LID - 14
AB  - PURPOSE: To measure the choroidal thickness in patients with high myopia from 
      staphyloma using swept source OCT (SS-OCT) in Early Treatment Diabetic 
      Retinopathy Study (ETDRS) fields and compare to normal cohort. The study also 
      evaluated the correlation between choroidal thickness with axial length and 
      best-corrected visual acuity (BCVA). METHODS: In this prospective cross sectional 
      study, 37 eyes of 20 patients with high myopia from staphyloma and 86 eyes of 43 
      normal subjects were included. In each eye, horizontal scans centered on the 
      fovea (12 x 9 mm) were performed using SS-OCT (DRI-OCT, Topcon, Japan). Choroidal 
      thickness in 9 ETDRS subfields, including central subfield (CSF) was analyzed and 
      correlated with axial length as well as BCVA. RESULTS: The axial length and BCVA 
      in the high myopia from staphyloma group ranged from 25.12 to 33.54 mm 
      (28.4 +/- 1.2) and 20/20-20/400, respectively. The choroidal thickness in 
      staphyloma group was 85.53 +/- 48.61 mum as compared to 250.24 +/- 71.01 mum in the 
      normal group (p < 0.0001). Stepwise regression analysis showed that axial length 
      strongly correlated with decreased choroidal thickness (p < 0.001) in staphyloma 
      group (r = 0.71, r (2) = 0.5). Refractive error and BCVA moderately 
      correlated(r = - 0.47; r (2) = 0.22) with choroidal thickness (p < 0.001). 
      CONCLUSION: Choroidal thickness in staphyloma (measured with novel technology of 
      SS-OCT) patients is markedly reduced compared to normal controls. In addition, 
      choroidal thickness strongly correlated with axial length of the eye and 
      inversely correlated with visual acuity. This testing modality maybe used as a 
      good predictor of visual acuity in patients with high myopia from staphyloma.
FAU - Chalam, K V
AU  - Chalam KV
AUID- ORCID: 0000-0002-0004-9416
AD  - Department of Ophthalmology, Loma Linda University School of Medicine, Loma 
      Linda, CA USA. ISNI: 0000 0000 9852 649X. GRID: grid.43582.38
FAU - Sambhav, Kumar
AU  - Sambhav K
AD  - Department of Ophthalmology, Loma Linda University School of Medicine, Loma 
      Linda, CA USA. ISNI: 0000 0000 9852 649X. GRID: grid.43582.38
LA  - eng
PT  - Journal Article
DEP - 20190709
PL  - England
TA  - Int J Retina Vitreous
JT  - International journal of retina and vitreous
JID - 101677897
PMC - PMC6615153
OTO - NOTNLM
OT  - Choroidal thickness
OT  - Staphyloma
OT  - Swept source optical coherence tomography
COIS- Competing interestsThe authors declare that they have no competing interests.
EDAT- 2019/07/25 06:00
MHDA- 2019/07/25 06:01
PMCR- 2019/07/09
CRDT- 2019/07/24 06:00
PHST- 2018/12/13 00:00 [received]
PHST- 2019/04/30 00:00 [accepted]
PHST- 2019/07/24 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2019/07/25 06:01 [medline]
PHST- 2019/07/09 00:00 [pmc-release]
AID - 166 [pii]
AID - 10.1186/s40942-019-0166-y [doi]
PST - epublish
SO  - Int J Retina Vitreous. 2019 Jul 9;5:14. doi: 10.1186/s40942-019-0166-y. 
      eCollection 2019.