PMID- 31334101
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2234-7550 (Print)
IS  - 2234-5930 (Electronic)
IS  - 1225-1585 (Linking)
VI  - 45
IP  - 3
DP  - 2019 Jun
TI  - Proton pump inhibitor intake negatively affects the osseointegration of dental 
      implants: a retrospective study.
PG  - 135-140
LID - 10.5125/jkaoms.2019.45.3.135 [doi]
AB  - OBJECTIVES: This study sought to investigate the association between the systemic 
      intake of proton pump inhibitors (PPI) and the early failure of dental implants. 
      MATERIALS AND METHODS: A retrospective cohort study involving 1,918 dental 
      implants in 592 patients (69 implants in 24 PPI users and 1,849 implants in 568 
      nonusers, respectively) was conducted. The effect of PPI intake on the 
      osseointegration of dental implants was evaluated using patient- and 
      implant-level models. RESULTS: Among 24 PPI users, two patients experienced 
      implant failure, one of whom had three and the other of whom had one failed 
      implant, respectively. Thus, the rate of failure for this population was 8.3%. 
      Separately, 11 nonusers each experienced one implant failure, and the failure 
      rate for these patients was 1.9%. Fisher's exact test revealed statistically 
      significant differences between PPI users and nonusers at the implant level 
      (P=0.002) but failed to show any significance at the patient level (P=0.094). The 
      odds of implant failure were 4.60 times greater among PPI users versus nonusers. 
      Dental implants that were placed in patients using PPIs were found to be 4.30 
      times more likely to fail prior to loading. CONCLUSION: The findings of this 
      study suggest that PPI intake may be associated with an increased risk of early 
      dental implant failure.
FAU - Altay, Mehmet Ali
AU  - Altay MA
AUID- ORCID: 0000-0001-8886-4783
AD  - Department of Oral and Maxillofacial Surgery, School of Dentistry, Akdeniz 
      University, Antalya, Turkey.
FAU - Sindel, Alper
AU  - Sindel A
AUID- ORCID: 0000-0001-8760-5958
AD  - Department of Oral and Maxillofacial Surgery, School of Dentistry, Akdeniz 
      University, Antalya, Turkey.
FAU - Ozalp, Oznur
AU  - Ozalp O
AUID- ORCID: 0000-0003-4350-1975
AD  - Department of Oral and Maxillofacial Surgery, School of Dentistry, Akdeniz 
      University, Antalya, Turkey.
FAU - Yildirimyan, Nelli
AU  - Yildirimyan N
AUID- ORCID: 0000-0001-9860-5494
AD  - Department of Oral and Maxillofacial Surgery, School of Dentistry, Akdeniz 
      University, Antalya, Turkey.
FAU - Kocabalkan, Burak
AU  - Kocabalkan B
AUID- ORCID: 0000-0002-7717-3765
AD  - Department of Oral and Maxillofacial Surgery, School of Dentistry, Akdeniz 
      University, Antalya, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20190628
PL  - Korea (South)
TA  - J Korean Assoc Oral Maxillofac Surg
JT  - Journal of the Korean Association of Oral and Maxillofacial Surgeons
JID - 101580242
PMC - PMC6620305
OTO - NOTNLM
OT  - Dental implantation
OT  - Osseointegration
OT  - Proton pump inhibitors
OT  - Rehabilitation
OT  - Risk factors
COIS- Conflict of Interest: No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2019/07/25 06:00
MHDA- 2019/07/25 06:01
PMCR- 2019/06/01
CRDT- 2019/07/24 06:00
PHST- 2018/07/11 00:00 [received]
PHST- 2018/08/05 00:00 [revised]
PHST- 2018/08/08 00:00 [accepted]
PHST- 2019/07/24 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2019/07/25 06:01 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
AID - 10.5125/jkaoms.2019.45.3.135 [doi]
PST - ppublish
SO  - J Korean Assoc Oral Maxillofac Surg. 2019 Jun;45(3):135-140. doi: 
      10.5125/jkaoms.2019.45.3.135. Epub 2019 Jun 28.