PMID- 31334239
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 6
DP  - 2019
TI  - A Randomized Trial of Split Dose 3 L Polyethylene Glycol Lavage Solution, 2 L 
      Polyethylene Glycol Lavage Combined With Castor Oil, and 1 L of Polyethylene 
      Glycol Lavage Solution Combined With Castor Oil and Ascorbic Acid for Preparation 
      for Colonoscopy.
PG  - 158
LID - 10.3389/fmed.2019.00158 [doi]
LID - 158
AB  - Background: Castor oil (CaO) has the potential of halving the required volume of 
      bowel preparation solution; however, no clinical trial investigated the efficacy 
      of CaO on bowel preparation for colonoscopy in addition to polyethylene glycol 
      (PEG). Objectives: Our aim was to evaluate efficacy and safety of lower dose PEG 
      together with 30 mL CaO alone or plus ascorbic acid (Asc) in bowel preparation 
      before colonoscopy. Methods: Two hundred and forty-six patients were allocated 
      randomly to ingest 2 L PEG with 30 mL CaO, 1 L PEG with 30 mL CaO plus 5 g Asc, 
      or 3 L PEG. We used Boston Bowel Preparation Scale (BBPS) to evaluate bowel 
      preparation efficacy. We also determined other outcomes such as procedure time, 
      polyp or adenoma detection rate, and adverse events (AEs). Results: Of 282 
      patients recruited, 36 were excluded. Groups were matched for baseline 
      characteristics except weight (P = 0.020) and body mass index (BMI) (P = 0.003). 
      Patient's satisfaction was higher in 2 L PEG-CaO (P = 0.016) and 1 L PEG-CaO-Asc 
      groups (P = 0.017). Patients' compliance was 67.5, 71.4, and 80.5% in 3 L PEG, 2 
      L PEG-CaO, and 1 L PEG-CaO-Asc groups (P = 0.014). Adequate bowel preparation 
      rate was 75, 78.57, and 53.66% in 3 L PEG, 2 L PEG-CaO, and 1 L PEG-CaO-Asc 
      groups (P = 0.021). There were no differences in terms of remaining outcomes. 
      Conclusions: Despite an increase in patients' satisfaction and compliance, 1 L 
      PEG-CaO-Asc significantly decreased adequate bowel preparation rate. However, 2 L 
      PEG-CaO improved the patients' satisfaction and compliance and increased adequate 
      bowel preparation rate (Registration number, ChiCTR-IIR-17012418).
FAU - Tian, Xu
AU  - Tian X
AD  - Key Laboratory for Biorheological Science and Technology, Department of 
      Gastroenterology, Chongqing University Cancer Hospital, Chongqing Cancer 
      Institute, Chongqing Cancer Hospital, Chongqing University, Ministry of 
      Education, Chongqing, China.
FAU - Shi, Bing
AU  - Shi B
AD  - Key Laboratory for Biorheological Science and Technology, Department of 
      Gastroenterology, Chongqing University Cancer Hospital, Chongqing Cancer 
      Institute, Chongqing Cancer Hospital, Chongqing University, Ministry of 
      Education, Chongqing, China.
FAU - Liu, Xiao-Ling
AU  - Liu XL
AD  - Key Laboratory for Biorheological Science and Technology, Department of 
      Gastroenterology, Chongqing University Cancer Hospital, Chongqing Cancer 
      Institute, Chongqing Cancer Hospital, Chongqing University, Ministry of 
      Education, Chongqing, China.
FAU - Chen, Hui
AU  - Chen H
AD  - Chongqing Key Laboratory of Translational Research for Cancer Metastasis and 
      Individualized Treatment, Department of Gastroenterology, Chongqing University 
      Cancer Hospital, Chongqing Cancer Institute, Chongqing Cancer Hospital, 
      Chongqing, China.
FAU - Chen, Wei-Qing
AU  - Chen WQ
AD  - Key Laboratory for Biorheological Science and Technology, Department of 
      Gastroenterology, Chongqing University Cancer Hospital, Chongqing Cancer 
      Institute, Chongqing Cancer Hospital, Chongqing University, Ministry of 
      Education, Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20190705
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC6624777
OTO - NOTNLM
OT  - ascorbic acid
OT  - bowel preparation
OT  - castor oil
OT  - colonoscopy
OT  - polyethylene glycol
EDAT- 2019/07/25 06:00
MHDA- 2019/07/25 06:01
PMCR- 2019/07/05
CRDT- 2019/07/24 06:00
PHST- 2019/04/17 00:00 [received]
PHST- 2019/06/25 00:00 [accepted]
PHST- 2019/07/24 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2019/07/25 06:01 [medline]
PHST- 2019/07/05 00:00 [pmc-release]
AID - 10.3389/fmed.2019.00158 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2019 Jul 5;6:158. doi: 10.3389/fmed.2019.00158. eCollection 
      2019.