PMID- 31336481
OWN - NLM
STAT- MEDLINE
DCOM- 20191230
LR  - 20191230
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 13
IP  - 2
DP  - 2019 Mar-Apr
TI  - Toll-like receptor 2 expression on monocytes and microvascular complications in 
      type 2 diabetic patients.
PG  - 1299-1302
LID - S1871-4021(18)30525-3 [pii]
LID - 10.1016/j.dsx.2019.01.038 [doi]
AB  - Diabetes mellitus (DM) is a chronic debilitating illness, and atherosclerotic 
      changes are inevitable and usually neglected during the follow-up of diabetic 
      patients. Toll-like receptor 2 (TLR2) is under trial in many studies to hold 
      responsibility for atherosclerosis process progression as they suggest a 
      malfunction of these receptors expressed on monocytes in diabetic patients. This 
      study aimed to assess the association between the TLR2 and type 2 diabetes 
      mellitus (T2DM) in Egyptian diabetic patients and to investigate its relationship 
      with some diabetic complications. METHODS: This study included a 60 diabetic 
      patients group 1 (diabetic complicated), group 2 (diabetic non-complicated) and 
      30 age-matched normal healthy blood donors. RESULTS: Toll-like receptors (TLRs) 
      expression was significantly associated with T2DM. In this study, the mean 
      fluorescent intensity (MFI) of TLR2 was 596.9 +/- 84.78 in group 1, 326.23 +/- 62.98 
      in group 2 while in group 3 it was 208.47 +/- 156.73. There was a significant 
      correlation between MFI of TLR2 and random blood sugar (RBS) and glycated 
      haemoglobin (HbA1c) (p < 0.05). CONCLUSION: TLR2 was overexpressed in diabetic 
      patients with microvascular complications compared to diabetic non-complicated 
      patients and normal healthy controls.
CI  - Copyright (c) 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Badr, Rasha Emad
AU  - Badr RE
AD  - Lecturer of Clinical and Chemical Pathology Department, Faculty of Medicine, 
      Portsaid University, Portsaid, Egypt. Electronic address: 
      dr.rashaemad@hotmail.com.
FAU - Salama, Mona Ibrahim
AU  - Salama MI
AD  - Lecturer of Clinical and Chemical Pathology Department, Faculty of Medicine, 
      Portsaid University, Portsaid, Egypt.
FAU - Abd-Elmaogood, Asmaa Kamal
AU  - Abd-Elmaogood AK
AD  - Lecturer of Clinical and Chemical Pathology Department, Faculty of Medicine, Suez 
      Canal University, Egypt.
FAU - Eldeib, Abd El-Raouf Mohamed
AU  - Eldeib AEM
AD  - Professor of Internal Medicine Department, Faculty of Medicine, Suez Canal 
      University, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20190126
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
RN  - 0 (Biomarkers)
RN  - 0 (TLR2 protein, human)
RN  - 0 (Toll-Like Receptor 2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/*metabolism
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Angiopathies/*diagnosis/etiology/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*metabolism
MH  - Prognosis
MH  - Toll-Like Receptor 2/*metabolism
MH  - Young Adult
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Mean fluorescent intensity
OT  - Random blood sugar
OT  - Toll-like receptor 2
EDAT- 2019/07/25 06:00
MHDA- 2019/12/31 06:00
CRDT- 2019/07/25 06:00
PHST- 2018/11/05 00:00 [received]
PHST- 2018/12/15 00:00 [revised]
PHST- 2019/01/22 00:00 [accepted]
PHST- 2019/07/25 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2019/12/31 06:00 [medline]
AID - S1871-4021(18)30525-3 [pii]
AID - 10.1016/j.dsx.2019.01.038 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1299-1302. doi: 
      10.1016/j.dsx.2019.01.038. Epub 2019 Jan 26.