PMID- 31336502
OWN - NLM
STAT- MEDLINE
DCOM- 20191230
LR  - 20191230
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 13
IP  - 2
DP  - 2019 Mar-Apr
TI  - The influence of insulin resistance in the occurence of non-alcoholic fatty liver 
      disease among first degree relatives of type 2 diabetes.
PG  - 1431-1435
LID - S1871-4021(19)30040-2 [pii]
LID - 10.1016/j.dsx.2019.01.058 [doi]
AB  - BACKGROUND: First degree relatives (FDR) of type 2 diabetes mellitus (T2DM) 
      predisposes individuals to have earlier metabolic and vascular disorders 
      independent of insulin resistance (IR) such as thicker carotid intima media 
      thickness than that of non-FDR. Non-alcoholic fatty liver disease (NAFLD) is the 
      most commonly found chronic liver disease in T2DM which is IR dependent. Studies 
      about NAFLD in FDR of T2DM populations are very limited and inconclusive. It is 
      unclear whether the occurrence of NAFLD in FDR of T2DM is IR dependent or due to 
      genetic vulnerability. AIMS: The aim of this study is to determine the 
      association between NAFLD and FDR of T2DM. METHOD AND MATERIALS: A total of 118 
      young adults (19-39 years old) with normal glucose tolerance (59 FDR of T2DM and 
      age-sex matched 59 non-FDR subjects) were included in this cross-sectional study. 
      Anthropometric measurement and routine laboratory analysis (fasting blood 
      glucose/FBG, HbA1c, lipid profile, alanine aminotransferase (ALT), aspartate 
      transaminase (AST)) were examined. Fatty liver was diagnosed by ultrasonography 
      (US) using standard criteria. RESULTS: Twenty-six (22,03%) subjects with NAFLD 
      were detected by ultrasound with similar proportion for each group. Low HDL-C 
      level and metabolic syndrome were found higher in FDR group (p = 0.004, OR 3.81, 
      CI95 = 1.47-9,91; p = 0.023, OR 4.28, CI95 = 1.13-16.23). Based on logistic 
      regression analysis, central obesity and obesity had statistically significant 
      influence towards NAFLD. CONCLUSION: The occurrence of NAFLD in FDR of T2DM was 
      influenced by IR (central obesity and obesity).
CI  - Copyright (c) 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Hazim, Ahmad
AU  - Hazim A
AD  - Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. 
      Cipto Mangunkusumo National Referral Hospital, Indonesia.
FAU - Purnamasari, Dyah
AU  - Purnamasari D
AD  - Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, 
      Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, 
      Indonesia. Electronic address: dyah_p_irawan@yahoo.com.
FAU - Kalista, Kemal F
AU  - Kalista KF
AD  - Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine, 
      Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, 
      Indonesia.
FAU - Lesmana, C Rinaldi A
AU  - Lesmana CRA
AD  - Division of Hepatobiliary, Department of Internal Medicine, Faculty of Medicine, 
      Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, 
      Indonesia.
FAU - Nugroho, Pringgodigdo
AU  - Nugroho P
AD  - Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, 
      Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, 
      Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20190131
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*genetics/physiopathology
MH  - Female
MH  - Follow-Up Studies
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Indonesia/epidemiology
MH  - *Insulin Resistance
MH  - Male
MH  - Non-alcoholic Fatty Liver Disease/*epidemiology
MH  - Prognosis
MH  - Young Adult
OTO - NOTNLM
OT  - Central obesity
OT  - First-degree relatives
OT  - Insulin resistance
OT  - Non-alcoholic fatty liver disease
OT  - Obesity
OT  - Type 2 diabetes mellitus
EDAT- 2019/07/25 06:00
MHDA- 2019/12/31 06:00
CRDT- 2019/07/25 06:00
PHST- 2019/01/21 00:00 [received]
PHST- 2019/01/28 00:00 [accepted]
PHST- 2019/07/25 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2019/12/31 06:00 [medline]
AID - S1871-4021(19)30040-2 [pii]
AID - 10.1016/j.dsx.2019.01.058 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1431-1435. doi: 
      10.1016/j.dsx.2019.01.058. Epub 2019 Jan 31.