PMID- 31337377
OWN - NLM
STAT- MEDLINE
DCOM- 20201009
LR  - 20231013
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Jul 23
TI  - HLA A*32 is associated to HIV acquisition while B*44 and B*53 are associated with 
      protection against HIV acquisition in perinatally exposed infants.
PG  - 249
LID - 10.1186/s12887-019-1620-6 [doi]
LID - 249
AB  - BACKGROUND: Human leukocyte antigen (HLA) molecules play a key role in the 
      cellular immune system. They may be determinants of mother-to-child transmission 
      which is the driving force in pediatric HIV infection. We intended to look at the 
      impact of the distribution of these polymorphic HLA genes in the mother-to-child 
      transmission (MTCT) of HIV in Cameroon. METHODS: A total of 156 mother-baby pairs 
      were enrolled in three hospitals of Yaounde, capital of Cameroon. After the 
      extraction of the DNA from blood samples using the Qiagen Kit as per 
      manufacturer' instructions, the polymorphism of the HLA class 1 ABC was 
      determined using the PCR- sequence specific primers assay. RESULTS: The 
      distribution of HLA class 1 revealed that none of the allele studied was 
      associated with transmitters or non-transmitters, so was not implicated in 
      transmission. The regression analysis showed that HLA A*32 [OR 0.062 (CI; 0.0075 
      to 0.51)] is associated with HIV acquisition while HLA B*44 [OR 0.47 (CI; 0.21 to 
      1.14)] and HLA B*53 [OR; 0.14 (CI; 0.018 to 1.22)] were implicated in reducing 
      the acquisition of HIV by infants. The homozygosity of locus C [OR 6.99 (CI; 1.81 
      to 26.88), p = 0.0027] was found as a risk factor for the acquisition, while the 
      A*32-B*44 haplotype [OR 10.1 (CI 1.17 to 87.87), p = 0.03] was a risk factor for 
      the transmission. CONCLUSION: This study has found that HLA A*32, B*44 and B*53 
      have an impact in MTCT outcomes. The homozygosity of locus C and the A*32-B*44 
      haplotype were risk factors for acquisition and transmission respectively.
FAU - Mekue, Linda Mouafo
AU  - Mekue LM
AD  - Faculty of Science, University of Dschang, P.O. Box 56, Dschang, Cameroon.
AD  - Chantal BIYA International Reference Centre, P.O. Box 3077, Yaounde, Cameroon.
AD  - Laboratory of Animal Physiology and Health, Institute of Agriculture Research for 
      Development (IRAD), P.O Box 2123, Bambui, Cameroon.
FAU - Nkenfou, Celine Nguefeu
AU  - Nkenfou CN
AD  - Chantal BIYA International Reference Centre, P.O. Box 3077, Yaounde, Cameroon. 
      nkenfou@yahoo.com.
AD  - Higher Teacher Training College, University of Yaounde I, P.O. Box 47, Yaounde, 
      Cameroon. nkenfou@yahoo.com.
FAU - Ndukong, Elvis
AU  - Ndukong E
AD  - Faculty of Science, University of Dschang, P.O. Box 56, Dschang, Cameroon.
AD  - Chantal BIYA International Reference Centre, P.O. Box 3077, Yaounde, Cameroon.
AD  - Laboratory of Animal Physiology and Health, Institute of Agriculture Research for 
      Development (IRAD), P.O Box 2123, Bambui, Cameroon.
FAU - Yatchou, Leaticia
AU  - Yatchou L
AD  - Chantal BIYA International Reference Centre, P.O. Box 3077, Yaounde, Cameroon.
FAU - Dambaya, Beatrice
AU  - Dambaya B
AD  - Chantal BIYA International Reference Centre, P.O. Box 3077, Yaounde, Cameroon.
FAU - Ngoufack, Marie-Nicole
AU  - Ngoufack MN
AD  - Chantal BIYA International Reference Centre, P.O. Box 3077, Yaounde, Cameroon.
FAU - Kameni, Joel Kadji
AU  - Kameni JK
AD  - Chantal BIYA International Reference Centre, P.O. Box 3077, Yaounde, Cameroon.
FAU - Kuiate, Jules-Roger
AU  - Kuiate JR
AD  - Faculty of Science, University of Dschang, P.O. Box 56, Dschang, Cameroon.
FAU - Ndjolo, Alexis
AU  - Ndjolo A
AD  - Chantal BIYA International Reference Centre, P.O. Box 3077, Yaounde, Cameroon.
AD  - Faculty of Medicine and Biomedical Science, University of Yaounde I, P.O BOX 
      1364, Yaounde, Cameroon.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190723
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*32 antigen)
RN  - 0 (HLA-B44 Antigen)
RN  - 0 (HLA-B53 antigen)
SB  - IM
MH  - Adult
MH  - Female
MH  - HIV Infections/*transmission
MH  - HLA Antigens
MH  - HLA-A Antigens/*genetics
MH  - HLA-B44 Antigen
MH  - Haplotypes
MH  - *Homozygote
MH  - Humans
MH  - Infant
MH  - *Infectious Disease Transmission, Vertical
PMC - PMC6647251
OTO - NOTNLM
OT  - Cameroon
OT  - HIV
OT  - HIV acquisition
OT  - HLA genotype
OT  - Haplotype
OT  - Homozygosity
OT  - Mother-to-child transmission
COIS- The authors declare that they have no competing interests.
EDAT- 2019/07/25 06:00
MHDA- 2020/10/10 06:00
PMCR- 2019/07/23
CRDT- 2019/07/25 06:00
PHST- 2018/12/03 00:00 [received]
PHST- 2019/07/10 00:00 [accepted]
PHST- 2019/07/25 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2020/10/10 06:00 [medline]
PHST- 2019/07/23 00:00 [pmc-release]
AID - 10.1186/s12887-019-1620-6 [pii]
AID - 1620 [pii]
AID - 10.1186/s12887-019-1620-6 [doi]
PST - epublish
SO  - BMC Pediatr. 2019 Jul 23;19(1):249. doi: 10.1186/s12887-019-1620-6.