PMID- 31337970 OWN - NLM STAT- MEDLINE DCOM- 20200407 LR - 20231013 IS - 1449-2288 (Electronic) IS - 1449-2288 (Linking) VI - 15 IP - 7 DP - 2019 TI - A Mathematical Modelling of Initiation of Dendritic Cells-Induced T Cell Immune Response. PG - 1396-1403 LID - 10.7150/ijbs.33412 [doi] AB - Dendritic cells (DCs) are the most potent specialized antigen-presenting cells as now known, which play a crucial role in initiating and amplifying both the innate and adaptive immune responses. Immunologically, the motilities and T cell activation capabilities of DCs are closely related to the resulting immune responses. However, due to the complexity of the immune system, the dynamic changes in the number of cells during the peripheral tissue (e.g. skin and mucosa) immune response induced by DCs are still poorly understood. Therefore, this study simulated dynamic number changes of DCs and T cells in this process by constructing several ordinary differential equations and setting the initial conditions of the functions and parameters. The results showed that these equations could simulate dynamic numerical changes of DCs and T cells in peripheral tissue and lymph node, which was in accordance with the physiological conditions such as the duration of immune response, the proliferation rates and the motilities of DCs and T cells. This model provided a theoretical reference for studying the immunologic functions of DCs and practical guidance for the clinical DCs-based therapy against immune-related diseases. FAU - Huang, Wen-Zhu AU - Huang WZ AD - Department of Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. FAU - Hu, Wen-Hui AU - Hu WH AD - Department of Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. FAU - Wang, Yun AU - Wang Y AD - Department of Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Department of Immunology, School of Basic Medical Science, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. FAU - Chen, Jin AU - Chen J AD - Department of Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. FAU - Hu, Zu-Quan AU - Hu ZQ AD - Department of Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. FAU - Zhou, Jing AU - Zhou J AD - Department of Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. FAU - Liu, Lina AU - Liu L AD - Department of Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. FAU - Qiu, Wei AU - Qiu W AD - Department of Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. FAU - Tang, Fu-Zhou AU - Tang FZ AD - Department of Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. FAU - Zhang, Shi-Chao AU - Zhang SC AD - Department of Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. FAU - Ouyang, Yan AU - Ouyang Y AD - Department of Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. FAU - Ye, Yuan-Nong AU - Ye YN AD - Department of Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Department of Immunology, School of Basic Medical Science, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. FAU - Xu, Guo-Qiang AU - Xu GQ AD - Department of Immunology, School of Basic Medical Science, Guizhou Medical University, Guiyang, 550004, P.R. China. FAU - Long, Jin-Hua AU - Long JH AD - Department of Head & Neck, Affiliated Tumor Hospital, Guizhou Medical University, Guiyang, 550004, P.R. China. FAU - Zeng, Zhu AU - Zeng Z AD - Department of Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Department of Immunology, School of Basic Medical Science, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Immune Cells and Antibody Engineering Research Center of Guizhou Province/Key Laboratory of Biology and Medical Engineering, Guizhou Medical University, Guiyang, 550004, P.R. China. AD - Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, 550025, P.R. China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190520 PL - Australia TA - Int J Biol Sci JT - International journal of biological sciences JID - 101235568 RN - 0 (Antigens) SB - IM MH - Antigens/immunology MH - Cell Movement MH - Cell Proliferation MH - Dendritic Cells/*cytology MH - Humans MH - *Immunity, Cellular MH - Immunotherapy MH - Inflammation MH - Lymph Nodes/pathology MH - Lymphocyte Activation MH - *Models, Theoretical MH - T-Lymphocytes/*cytology PMC - PMC6643141 OTO - NOTNLM OT - T cells OT - dendritic cell OT - immune response OT - mathematical model OT - ordinary differential equations COIS- Competing Interests: The authors have declared that no competing interest exists. EDAT- 2019/07/25 06:00 MHDA- 2020/04/09 06:00 PMCR- 2019/01/01 CRDT- 2019/07/25 06:00 PHST- 2019/01/22 00:00 [received] PHST- 2019/03/19 00:00 [accepted] PHST- 2019/07/25 06:00 [entrez] PHST- 2019/07/25 06:00 [pubmed] PHST- 2020/04/09 06:00 [medline] PHST- 2019/01/01 00:00 [pmc-release] AID - ijbsv15p1396 [pii] AID - 10.7150/ijbs.33412 [doi] PST - epublish SO - Int J Biol Sci. 2019 May 20;15(7):1396-1403. doi: 10.7150/ijbs.33412. eCollection 2019.