PMID- 31338033
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 10
DP  - 2019
TI  - Soshiho-Tang, a Traditional Herbal Medicine, Alleviates Atopic Dermatitis 
      Symptoms via Regulation of Inflammatory Mediators.
PG  - 742
LID - 10.3389/fphar.2019.00742 [doi]
LID - 742
AB  - Soshiho-tang (SST) is a well-known traditional herbal medicine used for the 
      treatment of many diseases. The aims of this study are to investigate the effects 
      of SST on atopic dermatitis (AD) symptoms and to examine its mechanism. Human 
      keratinocyte (HaCaT) cells were stimulated with tumor necrosis factor alpha 
      (TNF-alpha)/IFN-gamma to induce AD-like keratinocyte environment. 
      2,4-Dinitrochlorobenzene (DNCB) was used to induce AD-like skin lesions in the 
      dorsal skin of BALB/c mice. SST and dexamethasone were administered orally for 14 
      day. As a result, SST treatment increased the expression of heme oxygenase-1 
      (HO-1), an anti-oxidative factor, and the nuclear translocation of NF-E2 
      p45-related factor 2 (Nrf2). In addition, the treatment also decreased the 
      expression level of inflammatory mediator nuclear factor-kappaB (NF-kappaB) and the 
      adhesion molecule intercellular adhesion molecule-1 (ICAM-1). SST treatment (75 
      and 150 mg/kg) significantly relieved AD symptoms in DNCB-induced AD-like mice by 
      restoring skin thickness, spleen weight, immunoglobulin E (IgE), interleukin 4 
      (IL-4), pro-inflammatory cytokine expression, and expression of several other 
      mediators. We found that SST alleviates AD-like skin lesions and skin 
      inflammation by modulating various atopic symptoms and inflammatory mediators. 
      Therefore, SST can be used as an alternative drug for the treatment of AD.
FAU - Lee, Ji-Hyun
AU  - Lee JH
AD  - Department of Immunology and Institute of Medical Sciences, Medical School, 
      Chonbuk National University, Jeonju, South Korea.
FAU - Jo, Eun Hee
AU  - Jo EH
AD  - Research Center of Traditional Korean Medicine, Wonkwang University, Iksan, South 
      Korea.
AD  - Department of Acupuncture and Moxibustion, College of Korean Medicine, Wonkwang 
      University, Iksan, South Korea.
FAU - Lee, Bori
AU  - Lee B
AD  - Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental 
      Medicines Research Institute, Wonkwang University, Iksan, South Korea.
FAU - Noh, Hyeon Min
AU  - Noh HM
AD  - Korean Traditional Medicine Institute, Wonkwang University, Iksan, South Korea.
FAU - Park, Sunggu
AU  - Park S
AD  - Department of Korean Medical Ophthalmology & Otolarynglogy & Dermatology, College 
      of Korean Medicine, Wonkwang University, Iksan, South Korea.
FAU - Lee, Young-Mi
AU  - Lee YM
AD  - Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental 
      Medicines Research Institute, Wonkwang University, Iksan, South Korea.
FAU - Kim, Dae-Ki
AU  - Kim DK
AD  - Department of Immunology and Institute of Medical Sciences, Medical School, 
      Chonbuk National University, Jeonju, South Korea.
FAU - Park, Min Chel
AU  - Park MC
AD  - Research Center of Traditional Korean Medicine, Wonkwang University, Iksan, South 
      Korea.
AD  - Department of Korean Medical Ophthalmology & Otolarynglogy & Dermatology, College 
      of Korean Medicine, Wonkwang University, Iksan, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20190703
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC6626912
OTO - NOTNLM
OT  - 2,4-dinitrochlorobenzene
OT  - Soshiho-Tang
OT  - atopic dermatitis
OT  - inflammation
OT  - keratinocytes
OT  - oxidative stress
EDAT- 2019/07/25 06:00
MHDA- 2019/07/25 06:01
PMCR- 2019/07/03
CRDT- 2019/07/25 06:00
PHST- 2018/12/21 00:00 [received]
PHST- 2019/06/07 00:00 [accepted]
PHST- 2019/07/25 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2019/07/25 06:01 [medline]
PHST- 2019/07/03 00:00 [pmc-release]
AID - 10.3389/fphar.2019.00742 [doi]
PST - epublish
SO  - Front Pharmacol. 2019 Jul 3;10:742. doi: 10.3389/fphar.2019.00742. eCollection 
      2019.