PMID- 31338145
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2008-8140 (Print)
IS  - 2322-3618 (Electronic)
IS  - 2008-8140 (Linking)
VI  - 10
IP  - 2
DP  - 2019 Spring
TI  - Effects of L-carnitine and betamethasone on ischemia-reperfusion injuries and 
      sperm parameters following testicular torsion in a rat model.
PG  - 125-132
LID - 10.30466/vrf.2019.74767.2002 [doi]
AB  - Testicular torsion is a consequence of spermatic cord twisting which causes 
      progressive damage to the structure of the testis and reduces sperm quality and 
      usually results in infertility. In the present study, with the assumption of the 
      protective effects of L-carnitine and betamethasone against ischemia-reperfusion 
      (IR) injuries, their effects on twisted testicles were evaluated and compared. 
      Twenty Wistar rats were randomly divided into four groups and used in this study. 
      Except for the Sham (S) group, testicular IR was induced surgically in three 
      other groups, including Control (C), Betamethasone (BM), and L-carnitine (LC) 
      groups. Betamethasone and L-carnitine were injected before detorsion in the BM 
      and LC groups, respectively. After twelve hours of reperfusion, the testicles 
      were detached, and prepared for sperm parameters evaluation such as sperm count, 
      motility, viability, morphology, and chromatin quality, and histopathologic 
      evaluations, including mean seminiferous tubular diameter (MSTD), germinal 
      epithelial cell thickness (GECT), and Johnsen's mean testicular biopsy scoring 
      (MTBS). The MSTD, GECT, and healthy sperms in the C group were significantly 
      lower than the other groups, while the BM and LC groups were significantly 
      different from others in MTBS. The number of sperms and sperm motility in the BM 
      group was significantly higher than the C group. Sperm viability in the BM and LC 
      groups were significantly higher than the C group. The results of this study 
      showed that both L-carnitine and betamethasone similarly can be effective in 
      treating testicular IR injuries.
FAU - Kazemi-Darabadi, Siamak
AU  - Kazemi-Darabadi S
AD  - Department of Clinical Sciences, Faculty of Veterinary Medicine, University of 
      Tabriz, Tabriz, Iran.
FAU - Asadpour, Reza
AU  - Asadpour R
AD  - Department of Clinical Sciences, Faculty of Veterinary Medicine, University of 
      Tabriz, Tabriz, Iran.
FAU - Shahbazfar, Amir Ali
AU  - Shahbazfar AA
AD  - Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, 
      Tabriz, Iran.
FAU - Alizadeh, Sajjad
AU  - Alizadeh S
AD  - Graduate Student, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, 
      Iran.
LA  - eng
PT  - Journal Article
DEP - 20190615
PL  - Iran
TA  - Vet Res Forum
JT  - Veterinary research forum : an international quarterly journal
JID - 101625812
PMC - PMC6626646
OTO - NOTNLM
OT  - Betamethasone
OT  - Carnitine
OT  - Reperfusion injury
OT  - Sperm characteristics
OT  - Spermatic cord torsion
COIS- The authors declare that they have no conflict of interest.
EDAT- 2019/07/25 06:00
MHDA- 2019/07/25 06:01
PMCR- 2019/03/01
CRDT- 2019/07/25 06:00
PHST- 2017/11/04 00:00 [received]
PHST- 2018/01/09 00:00 [accepted]
PHST- 2019/07/25 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2019/07/25 06:01 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - 10.30466/vrf.2019.74767.2002 [doi]
PST - ppublish
SO  - Vet Res Forum. 2019 Spring;10(2):125-132. doi: 10.30466/vrf.2019.74767.2002. Epub 
      2019 Jun 15.