PMID- 31338275
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231012
IS  - 2191-1363 (Print)
IS  - 2191-1363 (Electronic)
IS  - 2191-1363 (Linking)
VI  - 8
IP  - 7
DP  - 2019 Jul
TI  - Mannose-Modified Multi-Walled Carbon Nanotubes as a Delivery Nanovector 
      Optimizing the Antigen Presentation of Dendritic Cells.
PG  - 915-921
LID - 10.1002/open.201900126 [doi]
AB  - Dendritic cells (DCs) based cancer immunotherapy is largely dependent on adequate 
      antigen delivery and efficient induction of DCs maturation to produce sufficient 
      antigen presentation and ultimately lead to substantial activation of 
      tumor-specific CD8(+) T cells. Carbon nanotubes (CNTs) have attracted great 
      attention in biomedicine because of their unique physicochemical properties. In 
      order to effectively deliver tumor antigens to DCs and trigger a strong 
      anti-tumor immune response, herein, a specific DCs target delivery system was 
      assembled by using multi-walled carbon nanotubes modified with mannose which can 
      specifically bind to the mannose receptor on DCs membrane. Ovalbumin (OVA) as a 
      model antigen, could be adsorbed on the surface of mannose modified multi-walled 
      carbon nanotubes (Man-MWCNTs) with a large drug loading content. This 
      nanotube-antigen complex showed low cytotoxicity to DCs and was efficiently 
      engulfed by DCs to induce DCs maturation and cytokine release in vitro, 
      indicating that it could be a potent antigen-adjuvant nanovector of efficient 
      antigen delivery for therapeutic purpose.
FAU - Dong, Zhipeng
AU  - Dong Z
AD  - Key Laboratory of Biomedical Functional Materials, School of Sciences China 
      Pharmaceutical University Nanjing 211198, Jiangsu Province China.
FAU - Wang, Qiyan
AU  - Wang Q
AD  - Key Laboratory of Biomedical Functional Materials, School of Sciences China 
      Pharmaceutical University Nanjing 211198, Jiangsu Province China.
FAU - Huo, Ming
AU  - Huo M
AD  - Key Laboratory of Biomedical Functional Materials, School of Sciences China 
      Pharmaceutical University Nanjing 211198, Jiangsu Province China.
FAU - Zhang, Nanxia
AU  - Zhang N
AD  - Key Laboratory of Biomedical Functional Materials, School of Sciences China 
      Pharmaceutical University Nanjing 211198, Jiangsu Province China.
FAU - Li, Bingxia
AU  - Li B
AD  - Key Laboratory of Biomedical Functional Materials, School of Sciences China 
      Pharmaceutical University Nanjing 211198, Jiangsu Province China.
FAU - Li, Hongmei
AU  - Li H
AD  - Key Laboratory of Biomedical Functional Materials, School of Sciences China 
      Pharmaceutical University Nanjing 211198, Jiangsu Province China.
FAU - Xu, Yisong
AU  - Xu Y
AD  - Key Laboratory of Biomedical Functional Materials, School of Sciences China 
      Pharmaceutical University Nanjing 211198, Jiangsu Province China.
FAU - Chen, Meng
AU  - Chen M
AD  - Nanjing Foreign Language School NO.30 East Beijing Road Nanjing 210029 China.
FAU - Hong, Hao
AU  - Hong H
AD  - Center for Molecular Imaging, Department of Radiology University of Michigan, Ann 
      Arbor, Michigan 48109-2200 United States.
FAU - Wang, Yue
AU  - Wang Y
AD  - Key Laboratory of Biomedical Functional Materials, School of Sciences China 
      Pharmaceutical University Nanjing 211198, Jiangsu Province China.
LA  - eng
PT  - Journal Article
DEP - 20190712
PL  - Germany
TA  - ChemistryOpen
JT  - ChemistryOpen
JID - 101594811
PMC - PMC6625155
OTO - NOTNLM
OT  - antigen presentation
OT  - carbon nanotubes
OT  - dendritic cells
OT  - drug delivery
OT  - immunotherapy
COIS- The authors declare no conflict of interest.
EDAT- 2019/07/25 06:00
MHDA- 2019/07/25 06:01
PMCR- 2019/07/01
CRDT- 2019/07/25 06:00
PHST- 2019/04/06 00:00 [received]
PHST- 2019/06/17 00:00 [revised]
PHST- 2019/07/25 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2019/07/25 06:01 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - OPEN201900126 [pii]
AID - 10.1002/open.201900126 [doi]
PST - epublish
SO  - ChemistryOpen. 2019 Jul 12;8(7):915-921. doi: 10.1002/open.201900126. eCollection 
      2019 Jul.