PMID- 31338850
OWN - NLM
STAT- MEDLINE
DCOM- 20210920
LR  - 20210920
IS  - 1096-9101 (Electronic)
IS  - 0196-8092 (Linking)
VI  - 52
IP  - 4
DP  - 2020 Apr
TI  - Effects of Low-Level Laser Irradiation in a Mouse Model of Allergic Rhinitis.
PG  - 347-357
LID - 10.1002/lsm.23141 [doi]
AB  - BACKGROUND AND OBJECTIVES: To evaluate the antiallergic effect of low-level laser 
      irradiation (LLLI) at 650 nm in a mouse model of allergic rhinitis (AR), and to 
      examine the underlying mechanisms. STUDY DESIGN/MATERIALS AND METHODS: BALB/c 
      mice were sensitized with ovalbumin (OVA) and alum and challenged intranasally 
      with OVA. Straight- and diffusion-type LLLI were applied directly into the 
      intranasal cavity of the mice once daily for 10 days (650 nm, 5 mW, 15 min/day) 
      and multiple allergic parameters were evaluated. RESULTS: LLLI reduced allergic 
      symptoms, such as rubbing and sneezing, and suppressed the serum total 
      immunoglobulin E (IgE), OVA-specific IgE, and OVA-specific IgG1 levels. 
      Diffusion-type LLLI significantly reduced eosinophil infiltration of nasal mucosa 
      and lymph nodes (LNs). LLLI reduced the expression of interleukin-4 (IL-4) and 
      IL-17 in cervical LN and splenocyte culture supernatant, as well as their 
      messenger RNA levels in nasal mucosa. However, the expression of interferongamma 
      (IFN-gamma) and IL-6 was unaffected by LLLI. The levels of reactive oxygen species 
      (ROS) and nitric oxide (NO) in LN cells and the nasal mucosa, which were 
      increased in the AR group, were reduced by LLLI, suggesting involvement of ROS 
      and NO within their mechanism. CONCLUSIONS: LLLI exerted an antiallergic effect 
      by decreasing local and systemic IL-4, IL-17, and IgE levels, as well as 
      eosinophilic infiltration into the nasal mucosa, in a mouse model of AR by 
      modulating ROS and NO levels. Diffusion-type LLLI exhibited greater efficacy 
      against AR than straight-type LLLI. Lasers Surg. Med. (c) 2019 Wiley Periodicals, 
      Inc.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Bae, Jun-Sang
AU  - Bae JS
AUID- ORCID: 0000-0003-2589-797X
AD  - Department of Otorhinolaryngology, Dankook University College of Medicine, 
      Cheonan, 31116, Republic of Korea.
AD  - Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, 
      31116, Republic of Korea.
FAU - Kim, Sang Hyub
AU  - Kim SH
AUID- ORCID: 0000-0001-8981-9749
AD  - Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, 
      31116, Republic of Korea.
FAU - Kim, Jie Hye
AU  - Kim JH
AUID- ORCID: 0000-0003-2516-774X
AD  - Department of Otorhinolaryngology, Dankook University College of Medicine, 
      Cheonan, 31116, Republic of Korea.
AD  - Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, 
      31116, Republic of Korea.
FAU - Kim, Eun Hee
AU  - Kim EH
AUID- ORCID: 0000-0002-9539-9928
AD  - Department of Otorhinolaryngology, Dankook University College of Medicine, 
      Cheonan, 31116, Republic of Korea.
AD  - Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, 
      31116, Republic of Korea.
FAU - Lyu, Lele
AU  - Lyu L
AUID- ORCID: 0000-0003-1600-0817
AD  - Department of Otorhinolaryngology, Dankook University College of Medicine, 
      Cheonan, 31116, Republic of Korea.
AD  - Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, 
      31116, Republic of Korea.
FAU - Chung, Phil Sang
AU  - Chung PS
AUID- ORCID: 0000-0003-4591-2276
AD  - Department of Otorhinolaryngology, Dankook University College of Medicine, 
      Cheonan, 31116, Republic of Korea.
AD  - Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, 
      31116, Republic of Korea.
AD  - Laser Translational Clinical Trial Center, Dankook University Hospital, Cheonan, 
      31116, Republic of Korea.
FAU - Mo, Ji-Hun
AU  - Mo JH
AUID- ORCID: 0000-0003-1331-364X
AD  - Department of Otorhinolaryngology, Dankook University College of Medicine, 
      Cheonan, 31116, Republic of Korea.
AD  - Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, 
      31116, Republic of Korea.
AD  - Laser Translational Clinical Trial Center, Dankook University Hospital, Cheonan, 
      31116, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190723
PL  - United States
TA  - Lasers Surg Med
JT  - Lasers in surgery and medicine
JID - 8007168
RN  - 0 (Cytokines)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/blood
MH  - *Low-Level Light Therapy
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Rhinitis, Allergic/immunology/metabolism/*radiotherapy
OTO - NOTNLM
OT  - allergic rhinitis
OT  - diffusion
OT  - low level laser irradiation
OT  - nitric oxide
OT  - reactive oxygen species
OT  - straight
EDAT- 2019/07/25 06:00
MHDA- 2021/09/21 06:00
CRDT- 2019/07/25 06:00
PHST- 2019/07/02 00:00 [accepted]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2021/09/21 06:00 [medline]
PHST- 2019/07/25 06:00 [entrez]
AID - 10.1002/lsm.23141 [doi]
PST - ppublish
SO  - Lasers Surg Med. 2020 Apr;52(4):347-357. doi: 10.1002/lsm.23141. Epub 2019 Jul 
      23.