PMID- 31339947
OWN - NLM
STAT- MEDLINE
DCOM- 20200225
LR  - 20200309
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 14
IP  - 7
DP  - 2019
TI  - Association of type 2 diabetes with anthropometrics, bone mineral density, and 
      body composition in a large-scale screening study of Korean adults.
PG  - e0220077
LID - 10.1371/journal.pone.0220077 [doi]
LID - e0220077
AB  - OBJECTIVES: Type 2 diabetes mellitus (T2DM) is a common, chronic disease that is 
      closely associated with anthropometric indices related to obesity. However, no 
      study published to date has simultaneously examined the associations of T2DM with 
      anthropometrics, bone mineral density (BMD), and body composition variables. The 
      present study aimed to evaluate the associations of T2DM with anthropometrics, 
      BMD and body composition variables and to identify the best indicator of T2DM in 
      Korean adults. METHODS: The data used in this study were obtained from the Korea 
      National Health and Nutrition Examination Survey conducted from 2008 to 2011. A 
      total of 7,835 participants aged from 40 to 90 years were included in this study. 
      A binary logistic regression analysis was performed to examine the significance 
      of differences between the groups with and without T2DM, and the areas under the 
      receiver operating characteristic (AUCs) curves were calculated to compare the 
      predictive power of all variables. RESULTS: In men, waist-to-height ratio (WHtR) 
      displayed the strongest association with T2DM (adjusted odds ratio (OR) = 1.838 
      [1.513-2.233], adjusted p<0.001), and waist circumference (WC) and WHtR were the 
      best indicators (WC: AUC = 0.662 [0.639-0.685], WHtR: AUC = 0.680 [0.658-0.703]) 
      of T2DM among all the variables. In women, left leg (LL) and right leg (RL) fat 
      displayed strong negative associations with T2DM (LL fat: adjusted OR = 0.367 
      [0.321-0.419], adjusted p<0.001, RL fat: adjusted OR = 0.375 [0.329-0.428], 
      adjusted p<0.001), and WC and WHtR were excellent indicators (WC: AUC = 0.730 
      [0.709-0.750], WHtR: AUC = 0.747 [0.728-0.766]) of T2DM among all the variables. 
      In particular, the WHtR in men and LL and RL fat in women exhibited the strongest 
      associations with T2DM, and the predictive power of the WC and WHtR was stronger 
      than BMD, fat, and muscle mass variables in both men and women. Additionally, the 
      predictive power of the WC and WHtR was stronger in women than in men. 
      DISCUSSION: Of the anthropometric indices, BMD, and body fat and muscle 
      variables, the best indicators of T2DM were WC and WHtR in both Korean men and 
      women. The results of the present investigation will provide basic information 
      for clinical studies of patients with T2DM and evidence for the prevention and 
      management of T2DM.
FAU - Chi, Jeong Hee
AU  - Chi JH
AD  - Department of Software, Konkuk University, Seoul, Republic of Korea.
FAU - Shin, Moon Sun
AU  - Shin MS
AD  - Department of Computer Engineering, Konkuk University, Chungju, Republic of 
      Korea.
FAU - Lee, Bum Ju
AU  - Lee BJ
AUID- ORCID: 0000-0003-2682-5716
AD  - Future Medicine Division, Korea Institute of Oriental Medicine, Deajeon, Republic 
      of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190724
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Body Composition
MH  - *Body Size
MH  - *Bone Density
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Republic of Korea
PMC - PMC6656355
COIS- The authors have declared that no competing interests exist.
EDAT- 2019/07/25 06:00
MHDA- 2020/02/26 06:00
PMCR- 2019/07/24
CRDT- 2019/07/25 06:00
PHST- 2019/03/05 00:00 [received]
PHST- 2019/07/07 00:00 [accepted]
PHST- 2019/07/25 06:00 [entrez]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2020/02/26 06:00 [medline]
PHST- 2019/07/24 00:00 [pmc-release]
AID - PONE-D-19-06341 [pii]
AID - 10.1371/journal.pone.0220077 [doi]
PST - epublish
SO  - PLoS One. 2019 Jul 24;14(7):e0220077. doi: 10.1371/journal.pone.0220077. 
      eCollection 2019.