PMID- 31340174
OWN - NLM
STAT- MEDLINE
DCOM- 20200914
LR  - 20200914
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 373
DP  - 2019 Nov 5
TI  - Preoperative vitamin-rich carbohydrate loading alleviates postoperative cognitive 
      dysfunction in aged rats.
PG  - 112107
LID - S0166-4328(19)30218-9 [pii]
LID - 10.1016/j.bbr.2019.112107 [doi]
AB  - With the acceleration of an aging population, postoperative cognitive dysfunction 
      (POCD) has become a large problem. Preoperative carbohydrate (CHO) loading has 
      been reported to attenuate surgery stress response and insulin resistance. The 
      present study aimed to investigate whether preoperative vitamin-rich CHO loading 
      has an effect on POCD, endoplasmic reticulum (ER) stress, and apoptosis. Eighty 
      male Sprague-Dawley rats (20-month old) were randomly assigned to four groups (20 
      per group): control group (no anesthesia and surgery), fasting group (fasting 
      14 h before surgery), water group (oral water 3 h before surgery), and CHO group 
      (oral vitamin-rich CHO 3 h before surgery). The POCD rat model was established by 
      splenectomy under intraperitoneal injection of pentobarbital sodium. Cognitive 
      function was assessed using the Morris water maze (MWM) after surgery. The levels 
      of endoplasmic reticulum (ER) stress markers and apoptosis related proteins in 
      the hippocampus were examined by western blot analysis. The vitamin-rich CHO 
      treated animals performed better in the MWM tests than the animals in the fasting 
      and water groups. Furthermore, preoperative CHO loading reduced ER stress and 
      neuronal apoptosis in the hippocampus of aged rats, as indicated by the protein 
      biomarkers of GRP78, eIF2a, Beclin1, Bax, and Bcl-2. In conclusion, preoperative 
      vitamin-rich CHO loading could improve POCD by attenuating ER stress and neural 
      apoptosis, providing a basis as a potential treatment against POCD.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Zuo, Youbo
AU  - Zuo Y
AD  - Department of Anesthesiology, Xinqiao Hospital, Army Medical University, 
      Chongqing 400037, China; Department of Anesthesiology, Affiliated Hospital of 
      North Sichuan Medical College, Nanchong 637000, China. Electronic address: 
      zuoyb2519@163.com.
FAU - Hu, Xingping
AU  - Hu X
AD  - Department of Emergency, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong 637000, China. Electronic address: 20509200@qq.com.
FAU - Yang, Qiuyan
AU  - Yang Q
AD  - Department of Emergency, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong 637000, China. Electronic address: 20509200@qq.com.
FAU - Zhao, Lei
AU  - Zhao L
AD  - Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical 
      College, Nanchong 637000, China.
FAU - Chen, Xueli
AU  - Chen X
AD  - Department of Anesthesiology, North Sichuan Medical College, Nanchong 637007, 
      China. Electronic address: 1312461434@qq.com.
FAU - Lin, Jiangtao
AU  - Lin J
AD  - Department of Anesthesiology, North Sichuan Medical College, Nanchong 637007, 
      China. Electronic address: 1312461434@qq.com.
FAU - Yang, Tiande
AU  - Yang T
AD  - Department of Anesthesiology, Xinqiao Hospital, Army Medical University, 
      Chongqing 400037, China. Electronic address: YTD0925@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190721
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Carbohydrates)
RN  - 0 (Vitamins)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Carbohydrates/*pharmacology
MH  - Cognition/drug effects
MH  - Cognitive Dysfunction/diet therapy/metabolism
MH  - Diet, Carbohydrate Loading/methods
MH  - Endoplasmic Reticulum Stress/drug effects
MH  - Fasting
MH  - Hippocampus/metabolism
MH  - Male
MH  - Maze Learning/drug effects
MH  - Postoperative Cognitive Complications/*diet therapy
MH  - Postoperative Complications/physiopathology
MH  - Preoperative Care/methods
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Vitamins/pharmacology
OTO - NOTNLM
OT  - Apoptosis
OT  - Carbohydrate
OT  - Endoplasmic reticulum stress
OT  - Hippocampus
OT  - Postoperative cognitive dysfunction
OT  - Rats
EDAT- 2019/07/25 06:00
MHDA- 2020/09/15 06:00
CRDT- 2019/07/25 06:00
PHST- 2019/02/09 00:00 [received]
PHST- 2019/07/15 00:00 [revised]
PHST- 2019/07/20 00:00 [accepted]
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2020/09/15 06:00 [medline]
PHST- 2019/07/25 06:00 [entrez]
AID - S0166-4328(19)30218-9 [pii]
AID - 10.1016/j.bbr.2019.112107 [doi]
PST - ppublish
SO  - Behav Brain Res. 2019 Nov 5;373:112107. doi: 10.1016/j.bbr.2019.112107. Epub 2019 
      Jul 21.