PMID- 31340393
OWN - NLM
STAT- MEDLINE
DCOM- 20220114
LR  - 20220114
IS  - 1439-3646 (Electronic)
IS  - 0947-7349 (Linking)
VI  - 129
IP  - 7
DP  - 2021 Jul
TI  - Circulating Serum Myonectin Levels in Obesity and Type 2 Diabetes Mellitus.
PG  - 528-534
LID - 10.1055/a-0896-8548 [doi]
AB  - OBJECTIVE: Myonectin is one of the myokines and has gained interest as a 
      potential new strategy to combat obesity and its associated disorders, such as 
      type 2 diabetes mellitus (T2DM).The objective of this study was to investigate 
      circulating serum myonectin levels in nondiabetes and T2DM and elucidate possible 
      relationships between serum myonectin levels and metabolic parameters in patients 
      with T2DM. DESIGN: A total of 362 Chinese patients with T2DM and 100 age- and 
      sex-matched healthy controls were recruited in this study. Clinical 
      characteristics, blood biochemistry, and circulating myonectin levels were 
      measured by enzyme-linked immunosorbent assay. RESULTS: Circulating myonectin 
      levels were significantly decreased in T2DM compared with controls. Obese 
      nondiabetic controls had significantly lower serum myonectin levels compared with 
      lean nondiabetic controls. In diabetic patients, serum myonectin concentrations 
      were significantly negatively correlated with body mass index (BMI), total 
      cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), 
      C-reactive protein (CRP), hemoglobin A1c (HbA1c), fasting insulin (Fins), the 
      homeostatic model assessment of insulin resistance (HOMA-IR), visceral fat area, 
      and subcutaneous fat area. After adjusting for covariates, multivariate stepwise 
      regression analysis demonstrated that BMI, LDL-C, TG, HOMA-IR, and visceral fat 
      were the main independent predictors of low serum myonectin concentrations. 
      CONCLUSIONS: Circulating myonectin levels were decreased in T2DM patients and in 
      obese subjects. Moreover, serum myonectin levels were correlated with metabolic 
      markers of T2DM. These data suggest that myonectin may be a useful marker in 
      predicting the development of obesity and T2DM.
CI  - Thieme. All rights reserved.
FAU - Li, Zhu
AU  - Li Z
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key 
      Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin 
      Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
FAU - Yang, Yan-Ling
AU  - Yang YL
AD  - Tianjin University of Traditional Chinese Medicine, Tianjin, China.
FAU - Zhu, Yan-Juan
AU  - Zhu YJ
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key 
      Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin 
      Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
FAU - Li, Chen-Guang
AU  - Li CG
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key 
      Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin 
      Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
FAU - Tang, Yun-Zhao
AU  - Tang YZ
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key 
      Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin 
      Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
FAU - Ni, Chang-Lin
AU  - Ni CL
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key 
      Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin 
      Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
FAU - Chen, Li-Ming
AU  - Chen LM
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key 
      Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin 
      Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
FAU - Niu, Wen-Yan
AU  - Niu WY
AD  - Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key 
      Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin 
      Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
AD  - Department of Immunology, Key Laboratory of Immuno Microenvironment and Disease 
      of the Educational Ministry of China, Tianjin Medical University, Tianjin, China.
LA  - eng
PT  - Journal Article
DEP - 20190724
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
RN  - 0 (Biomarkers)
RN  - 0 (C1QTNF5 protein, human)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Collagen/*blood
MH  - Diabetes Mellitus, Type 2/*blood/*diagnosis
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*blood/*diagnosis
COIS- The authors declare that they have no conflict of interest.
EDAT- 2019/07/25 06:00
MHDA- 2022/01/15 06:00
CRDT- 2019/07/25 06:00
PHST- 2019/07/25 06:00 [pubmed]
PHST- 2022/01/15 06:00 [medline]
PHST- 2019/07/25 06:00 [entrez]
AID - 10.1055/a-0896-8548 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2021 Jul;129(7):528-534. doi: 10.1055/a-0896-8548. 
      Epub 2019 Jul 24.