PMID- 31340522
OWN - NLM
STAT- MEDLINE
DCOM- 20200129
LR  - 20200225
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 11
IP  - 7
DP  - 2019 Jul 23
TI  - Infant Feeding, Vitamin D and IgE Sensitization to Food Allergens at 6 Years in a 
      Longitudinal Icelandic Cohort.
LID - 10.3390/nu11071690 [doi]
LID - 1690
AB  - Nordic Nutrition Recommendations (NNR) recommend exclusive breastfeeding until 6 
      months, partial breastfeeding until 1 year or longer and irrespective of 
      breastfeeding, avoiding solid foods before 4 months. Strong evidence was found 
      for benefits of breastfeeding regarding growth and infections but 
      limited/inconclusive evidence regarding atopic disease and asthma. Vitamin D is 
      of special interest in the Nordic diet. The aim of this prospective study was to 
      compare infant feeding and vitamin D between immunoglobulin E (IgE) sensitized (n 
      = 14) and non-sensitized (n = 130) children at 6 years. Information on diet and 
      vitamin D supplement use were collected with dietary recall (<5 months), 1-d food 
      records (5 and 6 months) and 3-d weighed food records (12 months and 6 years). 
      Serum-specific IgE-antibodies against milk, egg, cod, wheat, soy and peanut 
      (cut-off specific IgE >/= 0.35 kUA/L) were measured at 6 years and serum 
      25-hydroxyvitamin D at 12 months and 6 years. At 4 months, 57% of IgE sensitized 
      vs. 23% of non-sensitized children (p < 0.01) had received solid food. At 12 
      months, IgE sensitized children had a lower intake of vitamin D (median (25th, 
      75th percentiles): 3.9 mug/d (3.2, 7.2) vs. 8.1 mug/d (4.4, 12.3), p = 0.03) and at 
      6 years, fewer used vitamin D supplements regularly (23% vs. 56%, p = 0.03). 
      Introduction of solid foods prior to 4 months increased the odds of 
      IgE-sensitization, OR = 4.9 (95%, CI = 1.4-16.6) and vitamin D supplement at 6 
      years decreased the odds of IgE-sensitization, OR = 0.2 (95%, CI = 0.1-0.98), 
      adjusting for maternal smoking. These observations support the NNR in their 
      recommendation against introducing complementary solid foods before the age of 4 
      months. Furthermore, they support encouraging vitamin D intake for young children 
      at northern latitudes.
FAU - Thorisdottir, Birna
AU  - Thorisdottir B
AUID- ORCID: 0000-0001-7320-0116
AD  - Unit for Nutrition Research, Faculty of Food Science and Nutrition, School of 
      Health Sciences, University of Iceland and Landspitali University Hospital, 101 
      Reykjavik, Iceland. bth50@hi.is.
AD  - Faculty of Sociology, Anthropology and Folkloristics, School of Social Sciences, 
      University of Iceland, 101 Reykjavik, Iceland. bth50@hi.is.
FAU - Gunnarsdottir, Ingibjorg
AU  - Gunnarsdottir I
AD  - Unit for Nutrition Research, Faculty of Food Science and Nutrition, School of 
      Health Sciences, University of Iceland and Landspitali University Hospital, 101 
      Reykjavik, Iceland.
FAU - Vidarsdottir, Anna Gudrun
AU  - Vidarsdottir AG
AD  - Department of Immunology, Landspitali University Hospital, 101 Reykjavik, 
      Iceland.
FAU - Sigurdardottir, Sigurveig
AU  - Sigurdardottir S
AD  - Department of Immunology, Landspitali University Hospital, 101 Reykjavik, 
      Iceland.
AD  - Faculty of Medicine, University of Iceland, 101 Reykjavik, Iceland.
AD  - The Allergy Outpatient Department, Landspitali University Hospital, 108 
      Reykjavik, Iceland.
FAU - Birgisdottir, Bryndis Eva
AU  - Birgisdottir BE
AD  - Unit for Nutrition Research, Faculty of Food Science and Nutrition, School of 
      Health Sciences, University of Iceland and Landspitali University Hospital, 101 
      Reykjavik, Iceland.
FAU - Thorsdottir, Inga
AU  - Thorsdottir I
AD  - School of Health Sciences, University of Iceland, 101 Reykjavik, Iceland.
LA  - eng
GR  - HI15120056/Haskoli Islands/
GR  - 2014-2016/Haskoli Islands/
GR  - A-2016-034/Landspitali Haskolasjukrahus/
GR  - 050424031/Icelandic Centre for Research/
PT  - Comparative Study
PT  - Journal Article
DEP - 20190723
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
RN  - 1406-16-2 (Vitamin D)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Biomarkers/blood
MH  - *Breast Feeding
MH  - Child
MH  - *Dietary Supplements
MH  - Female
MH  - Food Hypersensitivity/blood/diagnosis/epidemiology/*immunology
MH  - Humans
MH  - Iceland/epidemiology
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - *Infant Food
MH  - Infant Formula
MH  - *Infant Nutritional Physiological Phenomena
MH  - Longitudinal Studies
MH  - Male
MH  - Nutritional Status
MH  - Prospective Studies
MH  - Recommended Dietary Allowances
MH  - Risk Factors
MH  - Vitamin D/*administration & dosage/metabolism
PMC - PMC6683021
OTO - NOTNLM
OT  - IgE sensitization
OT  - Nordic diet
OT  - breastfeeding
OT  - children
OT  - complementary feeding
OT  - infants
OT  - recommendations
OT  - solid food
OT  - vitamin D
COIS- The authors declare no conflict of interest.
EDAT- 2019/07/26 06:00
MHDA- 2020/01/30 06:00
PMCR- 2019/07/01
CRDT- 2019/07/26 06:00
PHST- 2019/06/14 00:00 [received]
PHST- 2019/07/15 00:00 [revised]
PHST- 2019/07/19 00:00 [accepted]
PHST- 2019/07/26 06:00 [entrez]
PHST- 2019/07/26 06:00 [pubmed]
PHST- 2020/01/30 06:00 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - nu11071690 [pii]
AID - nutrients-11-01690 [pii]
AID - 10.3390/nu11071690 [doi]
PST - epublish
SO  - Nutrients. 2019 Jul 23;11(7):1690. doi: 10.3390/nu11071690.