PMID- 31340562
OWN - NLM
STAT- MEDLINE
DCOM- 20200817
LR  - 20200817
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 11
IP  - 7
DP  - 2019 Jul 23
TI  - Deltaccr5 Genotype Is Associated with Mild Form of Nephropathia Epidemica.
LID - 10.3390/v11070675 [doi]
LID - 675
AB  - Nephropathia Epidemica (NE), a mild form of hemorrhagic fever with renal syndrome 
      (HFRS) and linked to hantavirus infection, is endemic in the Republic of 
      Tatarstan. Several genetic markers of HFRS severity have been identified 
      previously, including human leukocyte antigen (HLA) complexes and nucleotide 
      polymorphism in the tumor necrosis factor alpha (TNFalpha) gene. Still, our 
      understanding of the genetic markers of NE severity remains incomplete. The 
      frequency of the C-C chemokine receptor type 5 (CCR5) gene wild type and gene 
      with 32-base-pair deletion (Delta32CCR5) genotypes in 98 NE samples and 592 controls 
      was analyzed using PCR. Along with the serum levels of 94 analytes, a lack of 
      differences in the CCR5 genotype distribution between NE cases and the general 
      population suggests that the CCR5 genotype does not affect susceptibility to 
      hantavirus infection. However, in NE cases, significant variation in the serum 
      levels of the host matrix metalloproteases between functional CCR5 homozygous and 
      Delta32CCR5 heterozygous patients was detected. Also, the oliguric phase was longer, 
      while thrombocyte counts were lower in functional CCR5 homozygous as compared to 
      heterozygous NE cases. Our data, for the first time, presents the potential role 
      of the CCR5 receptor genotype in NE pathogenesis. Our data suggests that NE 
      pathogenesis in functional CCR5 homozygous and heterozygous NE patients differs, 
      where homozygous cases may have more disintegration of the extracellular matrix 
      and potentially more severe disease.
FAU - Kletenkov, Konstantin
AU  - Kletenkov K
AD  - Openlab "Gene and Cell Technologies", Institute of Fundamental Medicine and 
      Biology Kazan Federal University, Kazan 420008, Republic of Tatarstan, Russian.
FAU - Martynova, Ekaterina
AU  - Martynova E
AD  - Openlab "Gene and Cell Technologies", Institute of Fundamental Medicine and 
      Biology Kazan Federal University, Kazan 420008, Republic of Tatarstan, Russian.
FAU - Davidyuk, Yuriy
AU  - Davidyuk Y
AUID- ORCID: 0000-0002-4409-2942
AD  - Openlab "Gene and Cell Technologies", Institute of Fundamental Medicine and 
      Biology Kazan Federal University, Kazan 420008, Republic of Tatarstan, Russian.
FAU - Kabwe, Emmanuel
AU  - Kabwe E
AD  - Openlab "Gene and Cell Technologies", Institute of Fundamental Medicine and 
      Biology Kazan Federal University, Kazan 420008, Republic of Tatarstan, Russian.
FAU - Shamsutdinov, Anton
AU  - Shamsutdinov A
AD  - Openlab "Gene and Cell Technologies", Institute of Fundamental Medicine and 
      Biology Kazan Federal University, Kazan 420008, Republic of Tatarstan, Russian.
FAU - Garanina, Ekaterina
AU  - Garanina E
AD  - Openlab "Gene and Cell Technologies", Institute of Fundamental Medicine and 
      Biology Kazan Federal University, Kazan 420008, Republic of Tatarstan, Russian.
FAU - Shakirova, Venera
AU  - Shakirova V
AD  - Department of Infectious Diseases, Kazan State Medical Academy, Kazan 420012, the 
      Republic of Tatarstan, Russian.
FAU - Khaertynova, Ilsiyar
AU  - Khaertynova I
AUID- ORCID: 0000-0001-5347-4670
AD  - Department of Infectious Diseases, Kazan State Medical Academy, Kazan 420012, the 
      Republic of Tatarstan, Russian.
FAU - Anokhin, Vladimir
AU  - Anokhin V
AUID- ORCID: 0000-0003-1050-9081
AD  - Department of Pediatric Infectious Diseases, Kazan State Medical University, 
      Kazan 420012, Republic of Tatarstan, Russian.
FAU - Tarlinton, Rachael
AU  - Tarlinton R
AUID- ORCID: 0000-0003-3325-2311
AD  - School of Veterinary Medicine and Science, University of Nottingham, Loughborough 
      LE12 5RD, UK.
FAU - Rizvanov, Albert
AU  - Rizvanov A
AUID- ORCID: 0000-0002-9427-5739
AD  - Openlab "Gene and Cell Technologies", Institute of Fundamental Medicine and 
      Biology Kazan Federal University, Kazan 420008, Republic of Tatarstan, Russian.
FAU - Khaiboullina, Svetlana
AU  - Khaiboullina S
AD  - Openlab "Gene and Cell Technologies", Institute of Fundamental Medicine and 
      Biology Kazan Federal University, Kazan 420008, Republic of Tatarstan, Russian.
AD  - Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, 
      USA.
FAU - Morzunov, Sergey
AU  - Morzunov S
AD  - Department of Pathology, University of Nevada, Reno, NV 89557, USA. 
      smorzunov@medicine.nevada.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190723
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
RN  - 0 (CCR5 protein, human)
RN  - 0 (Receptors, CCR5)
SB  - IM
MH  - Female
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - *Genotype
MH  - Hemorrhagic Fever with Renal Syndrome/*diagnosis/*genetics
MH  - Humans
MH  - Male
MH  - *Mutation
MH  - Receptors, CCR5/*genetics
PMC - PMC6669606
OTO - NOTNLM
OT  - CCR5
OT  - cytokines
OT  - hemorrhagic fever with renal syndrome
OT  - matrix metalloprotease
OT  - nephropathia epidemica
OT  - Delta32CCR5
COIS- The authors declare no conflict of interest.
EDAT- 2019/07/26 06:00
MHDA- 2020/08/18 06:00
PMCR- 2019/07/01
CRDT- 2019/07/26 06:00
PHST- 2019/05/24 00:00 [received]
PHST- 2019/06/22 00:00 [revised]
PHST- 2019/07/17 00:00 [accepted]
PHST- 2019/07/26 06:00 [entrez]
PHST- 2019/07/26 06:00 [pubmed]
PHST- 2020/08/18 06:00 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - v11070675 [pii]
AID - viruses-11-00675 [pii]
AID - 10.3390/v11070675 [doi]
PST - epublish
SO  - Viruses. 2019 Jul 23;11(7):675. doi: 10.3390/v11070675.