PMID- 31341898
OWN - NLM
STAT- MEDLINE
DCOM- 20191224
LR  - 20231012
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2019
DP  - 2019
TI  - Jiedu Granule Combined with Transcatheter Arterial Chemoembolization and Gamma 
      Knife Radiosurgery in Treating Hepatocellular Carcinoma with Portal Vein Tumor 
      Thrombus.
PG  - 4696843
LID - 10.1155/2019/4696843 [doi]
LID - 4696843
AB  - BACKGROUND: The potential advantages of Jiedu granule (a compound Chinese herbal 
      medicine) combined therapeutic strategies compared with non-Jiedu granule 
      therapeutic strategies for hepatocellular carcinoma (HCC) with portal vein tumor 
      thrombosis (PVTT) remain unclear. Thus, the purpose of the study was to 
      investigate the safety and efficacy of Jiedu granule for HCC with PVTT. METHODS: 
      We retrospectively reviewed the clinical data of 190 patients (94 for non-Jiedu 
      and 96 for Jiedu) with HCC and PVTT from March 2012 to October 2016. Patients 
      were followed up by outpatient examination and telephone till November 2018. 
      RESULTS: It was statistically insignificant between the two groups in baseline 
      characteristics. Procedure-related adverse events (AEs) were observed and 
      compared and most of them were not serious which were easily controlled or 
      subsided naturally. No AE-induced death happened. The median overall survival 
      (OS) rates in the single TACE plus GKR and Jiedu granule combined group were 11.3 
      months (95% CI: 9.168-13.435) and 15.8 months (95% CI: 13.244-18.339), 
      respectively (p = 0.00047). CONCLUSIONS: Jiedu granule combined with TACE plus 
      GKR is safe in HCC patients with PVTT and this Chinese herbal medicine is worthy 
      to be promoted because of better prognosis which needs further research.
FAU - Wang, Jianchu
AU  - Wang J
AD  - Department of Hepatobiliary Surgery, Affiliated Hospital of Youjiang Medical 
      University for Nationalities, Baise, China.
FAU - Luo, Jinhong
AU  - Luo J
AD  - Department of Oncology, Shanghai East Hospital, Tongji University School of 
      Medicine, Shanghai, China.
FAU - Yin, Xiaolan
AU  - Yin X
AD  - Department of Radiotherapy, Changhai Hospital Hongkou District Affiliated to 
      Naval Medical University, Shanghai 200081, China.
FAU - Huang, Wei
AU  - Huang W
AD  - Department of Oncology, Shanghai East Hospital, Tongji University School of 
      Medicine, Shanghai, China.
FAU - Cao, Huangming
AU  - Cao H
AD  - Department of Oncology, Shanghai East Hospital, Tongji University School of 
      Medicine, Shanghai, China.
FAU - Wang, Guilin
AU  - Wang G
AD  - Department of Radiotherapy, Changhai Hospital Hongkou District Affiliated to 
      Naval Medical University, Shanghai 200081, China.
FAU - Wang, Jincheng
AU  - Wang J
AUID- ORCID: 0000-0001-9345-2388
AD  - Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing, China.
FAU - Zhou, Jun
AU  - Zhou J
AUID- ORCID: 0000-0001-7586-9905
AD  - Department of Oncology, Shanghai East Hospital, Tongji University School of 
      Medicine, Shanghai, China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20190625
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - *Carcinoma, Hepatocellular/mortality/therapy
MH  - *Chemoembolization, Therapeutic
MH  - Combined Modality Therapy
MH  - Drugs, Chinese Herbal/*administration & dosage
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - *Liver Neoplasms/mortality/therapy
MH  - Male
MH  - Middle Aged
MH  - *Portal Vein
MH  - *Radiosurgery
MH  - Retrospective Studies
MH  - *Venous Thrombosis/mortality/therapy
PMC - PMC6614979
EDAT- 2019/07/26 06:00
MHDA- 2019/12/25 06:00
PMCR- 2019/06/25
CRDT- 2019/07/26 06:00
PHST- 2019/05/05 00:00 [received]
PHST- 2019/06/08 00:00 [accepted]
PHST- 2019/07/26 06:00 [entrez]
PHST- 2019/07/26 06:00 [pubmed]
PHST- 2019/12/25 06:00 [medline]
PHST- 2019/06/25 00:00 [pmc-release]
AID - 10.1155/2019/4696843 [doi]
PST - epublish
SO  - Biomed Res Int. 2019 Jun 25;2019:4696843. doi: 10.1155/2019/4696843. eCollection 
      2019.