PMID- 31344242
OWN - NLM
STAT- MEDLINE
DCOM- 20200110
LR  - 20220220
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
VI  - 50
IP  - 7
DP  - 2019 Jul 1
TI  - OCT Angiography in Acute Posterior Multifocal Placoid Pigment Epitheliopathy.
PG  - 428-436
LID - 10.3928/23258160-20190703-04 [doi]
AB  - BACKGROUND AND OBJECTIVE: To describe retinal and choroidal findings in different 
      stages of acute posterior multifocal placoid pigment epitheliopathy (APMPPE). 
      PATIENTS AND METHODS: Retrospective, noncomparative case series studied by fundus 
      biomicroscopy, fundus autofluorescence (FAF), fluorescein angiography (FA), 
      indocyanine green angiography (ICGA), spectral-domain optical coherence 
      tomographic (SD-OCT), and swept-source OCT angiography (SS-OCTA). RESULTS: Six 
      eyes of three patients with bilateral APMPPE were included. FAF showed 
      multifocal, branched patches of hyperautofluorescence with areas of 
      hypoautofluorescence; FA disclosed early hypofluorescence, with late-phase 
      hyperfluorescence; ICGA showed early and late-phase hypofluorescence. SD-OCT 
      imaging revealed bilateral retinal thinning, external limiting membrane (ELM) 
      disruption, and severe alteration of the photoreceptor-retinal pigment epithelium 
      complex. SS-OCTA showed widespread multiple dark spots in the choriocapillaris in 
      Cases 1 and 2. Rarefaction and voids in the vascular texture were also detected 
      in the deep plexus, unlike in Case 3, where the lesions were smaller and earlier, 
      suggesting that retina vasculature may be affected after the choriocapillaris 
      obstruction. CONCLUSIONS: APMPPE may result from a distinct focal ischemia in the 
      choriocapillaris, and OCTA allowed the authors to localize exactly all the 
      placoid lesions and monitor the areas of absent fluid signal. [Ophthalmic Surg 
      Lasers Imaging Retina. 2019;50:428-436.].
CI  - Copyright 2019, SLACK Incorporated.
FAU - Furino, Claudio
AU  - Furino C
FAU - Shalchi, Zaid
AU  - Shalchi Z
FAU - Grassi, Maria Oliva
AU  - Grassi MO
FAU - Cardoso, Joao N
AU  - Cardoso JN
FAU - Keane, Pearse A
AU  - Keane PA
FAU - Niro, Alfredo
AU  - Niro A
FAU - Cicinelli, Maria Vittoria
AU  - Cicinelli MV
FAU - Reibaldi, Michele
AU  - Reibaldi M
FAU - Boscia, Francesco
AU  - Boscia F
FAU - Alessio, Giovanni
AU  - Alessio G
FAU - Pavesio, Carlos
AU  - Pavesio C
LA  - eng
GR  - CS-2014-14-023/DH_/Department of Health/United Kingdom
GR  - MC_PC_19005/MRC_/Medical Research Council/United Kingdom
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
SB  - IM
MH  - Adult
MH  - Fluorescein Angiography/methods
MH  - Humans
MH  - Male
MH  - Multifocal Choroiditis/*pathology
MH  - Retina/*pathology
MH  - Tomography, Optical Coherence/methods
MH  - White Dot Syndromes/*pathology
MH  - Young Adult
EDAT- 2019/07/26 06:00
MHDA- 2020/01/11 06:00
CRDT- 2019/07/26 06:00
PHST- 2018/07/19 00:00 [received]
PHST- 2019/01/17 00:00 [accepted]
PHST- 2019/07/26 06:00 [entrez]
PHST- 2019/07/26 06:00 [pubmed]
PHST- 2020/01/11 06:00 [medline]
AID - 10.3928/23258160-20190703-04 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2019 Jul 1;50(7):428-436. doi: 
      10.3928/23258160-20190703-04.