PMID- 31346324
OWN - NLM
STAT- MEDLINE
DCOM- 20200109
LR  - 20200225
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 2019
DP  - 2019
TI  - Modeling, Assessment, and Design of Porous Cells Based on Schwartz Primitive 
      Surface for Bone Scaffolds.
PG  - 7060847
LID - 10.1155/2019/7060847 [doi]
LID - 7060847
AB  - The design of bone scaffolds for tissue regeneration is a topic of great 
      interest, which involves different issues related to geometry of architectures, 
      mechanical behavior, and biological requirements, whose optimal combination 
      determines the success of an implant. Additive manufacturing (AM) has widened the 
      capability to produce structures with complex geometries, which should 
      potentially satisfy the different requirements. These architectures can be 
      obtained by means of refined methods and have to be assessed in terms of 
      geometrical and mechanical properties. In this paper a triply periodic minimal 
      surface (TPMS), the Schwarz's Primitive surface (P-surface), has been considered 
      as scaffold unit cell and conveniently parameterized in order to investigate the 
      effect of modulation of analytical parameters on the P-cell geometry and on its 
      properties. Several are the cell properties, which can affect the scaffold 
      performance. Due to the important biofunctional role that the surface curvature 
      plays in mechanisms of cellular proliferation and differentiation, in this paper, 
      in addition to properties considering the cell geometry in its whole (such as 
      volume fraction or pore size), new properties were proposed. These properties 
      involve, particularly, the evaluation of local geometrical-differential 
      properties of the P-surface. The results of this P-cell comprehensive 
      characterization are very useful for the design of customized bone scaffolds able 
      to satisfy both biological and mechanical requirements. A numerical structural 
      evaluation, by means of finite element method (FEM), was performed in order to 
      assess the stiffness of solid P-cells as a function of the changes of the 
      analytical parameters of outer surface and the thickness of cell. Finally, the 
      relationship between stiffness and porosity has been analyzed, given the 
      relevance that this property has for bone scaffolds design.
FAU - Ambu, Rita
AU  - Ambu R
AD  - Department of Mechanical, Chemical and Materials Engineering, University of 
      Cagliari, Via Marengo 2, 09123 Cagliari, Italy.
FAU - Morabito, Anna Eva
AU  - Morabito AE
AUID- ORCID: 0000-0001-8841-5558
AD  - Department of Engineering for Innovation, University of Salento, Via per 
      Monteroni, 73100 Lecce, Italy.
LA  - eng
PT  - Journal Article
DEP - 20190627
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
RN  - 0 (Bone Substitutes)
SB  - IM
MH  - Algorithms
MH  - *Artificial Cells/chemistry
MH  - *Bone Regeneration
MH  - Bone Substitutes/chemistry
MH  - Bone and Bones/*chemistry
MH  - Models, Structural
MH  - Porosity
MH  - Surface Properties
MH  - *Tissue Engineering/methods
MH  - Tissue Scaffolds/*chemistry
PMC - PMC6620862
EDAT- 2019/07/28 06:00
MHDA- 2020/01/10 06:00
PMCR- 2019/06/27
CRDT- 2019/07/27 06:00
PHST- 2019/01/31 00:00 [received]
PHST- 2019/06/04 00:00 [revised]
PHST- 2019/06/11 00:00 [accepted]
PHST- 2019/07/27 06:00 [entrez]
PHST- 2019/07/28 06:00 [pubmed]
PHST- 2020/01/10 06:00 [medline]
PHST- 2019/06/27 00:00 [pmc-release]
AID - 10.1155/2019/7060847 [doi]
PST - epublish
SO  - ScientificWorldJournal. 2019 Jun 27;2019:7060847. doi: 10.1155/2019/7060847. 
      eCollection 2019.