PMID- 31347485
OWN - NLM
STAT- MEDLINE
DCOM- 20200629
LR  - 20200629
IS  - 2040-1752 (Electronic)
IS  - 2040-1744 (Linking)
VI  - 10
IP  - 4
DP  - 2019 Aug
TI  - Maternal undernutrition results in altered renal pro-inflammatory gene expression 
      concomitant with hypertension in adult male offspring that is ameliorated 
      following pre-weaning growth hormone treatment.
PG  - 459-468
LID - 10.1017/S2040174418000922 [doi]
AB  - An adverse early life environment is associated with increased cardiovascular 
      disease in offspring. Work in animal models has shown that maternal 
      undernutrition (UN) during pregnancy leads to hypertension in adult offspring, 
      with effects thought to be mediated in part via altered renal function. We have 
      previously shown that growth hormone (GH) treatment of UN offspring during the 
      pre-weaning period can prevent the later development of cardiometabolic 
      disorders. However, the mechanistic basis for these observations is not well 
      defined. The present study examined the impact of GH treatment on renal 
      inflammatory markers in adult male offspring as a potential mediator of these 
      reversal effects. Female Sprague-Dawley rats were fed either a chow diet fed ad 
      libitum (CON) or at 50% of CON intake (UN) during pregnancy. All dams were fed 
      the chow diet ad libitum during lactation. CON and UN pups received saline 
      (CON-S/UN-S) or GH (2.5 microg/g/day; CON-GH/UN-GH) from postnatal day 3 until 
      weaning (p21). Post-weaning males were fed a standard chow diet for the remainder 
      of the study (150 days). Histological analysis was performed to examine renal 
      morphological characteristics, and gene expression of inflammatory and vascular 
      markers were assessed. There was evidence of renal hypotrophy and reduced nephron 
      number in the UN-S group. Tumour necrosis factor-alpha, monocyte chemoattractant 
      protein-1 (MCP-1), intercellular adhesion molecular-1 and vascular cell adhesion 
      molecule-1 gene expression was increased in UN-S offspring and normalized in the 
      UN-GH group. These findings indicate that pre-weaning GH treatment has the 
      potential to normalize some of the adverse renal and cardiovascular sequelae that 
      arise as a consequence of poor maternal nutrition.
FAU - Zhang, X D
AU  - Zhang XD
AD  - Liggins Institute, University of Auckland,Auckland,New Zealand.
FAU - Reynolds, C M
AU  - Reynolds CM
AD  - Liggins Institute, University of Auckland,Auckland,New Zealand.
FAU - Gray, C
AU  - Gray C
AD  - Liggins Institute, University of Auckland,Auckland,New Zealand.
FAU - Li, M
AU  - Li M
AD  - Liggins Institute, University of Auckland,Auckland,New Zealand.
FAU - Vickers, M H
AU  - Vickers MH
AD  - Liggins Institute, University of Auckland,Auckland,New Zealand.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Dev Orig Health Dis
JT  - Journal of developmental origins of health and disease
JID - 101517692
RN  - 0 (Inflammation Mediators)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Animals
MH  - Female
MH  - Gene Expression Regulation/*drug effects
MH  - Growth Hormone/*administration & dosage
MH  - Hypertension/*drug therapy/etiology
MH  - Inflammation/*drug therapy/etiology/metabolism
MH  - Inflammation Mediators/*metabolism
MH  - Kidney/*drug effects/immunology/pathology
MH  - Male
MH  - Malnutrition/*complications
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Weaning
OTO - NOTNLM
OT  - renal inflammation
OT  - cardiovascular disease
OT  - developmental programming
OT  - hypertension
OT  - maternal undernutrition
EDAT- 2019/07/28 06:00
MHDA- 2020/07/01 06:00
CRDT- 2019/07/27 06:00
PHST- 2019/07/27 06:00 [entrez]
PHST- 2019/07/28 06:00 [pubmed]
PHST- 2020/07/01 06:00 [medline]
AID - S2040174418000922 [pii]
AID - 10.1017/S2040174418000922 [doi]
PST - ppublish
SO  - J Dev Orig Health Dis. 2019 Aug;10(4):459-468. doi: 10.1017/S2040174418000922.