PMID- 31347617
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20190823
IS  - 1364-5528 (Electronic)
IS  - 0003-2654 (Linking)
VI  - 144
IP  - 17
DP  - 2019 Sep 7
TI  - Separation and detection of cyproconazole enantiomers and its stereospecific 
      recognition with chiral stationary phase by high-performance liquid 
      chromatography.
PG  - 5193-5200
LID - 10.1039/c9an00950g [doi]
AB  - Cyproconazole, a chiral triazole fungicide, has been diffusely used and analyzed. 
      The development of an effective analytical method for cyproconazole enantiomers 
      can support their residual monitoring and risk assessment. In the present study, 
      the absolute configuration of the cyproconazole enantiomers was confirmed by 
      electronic circular dichroism and time-dependent density functional theory. The 
      enantioseparation parameters were optimized by the response surface methodology 
      using the Box-Behnken design on Lux Cellulose-2. The elution order of 
      (2S,3R)-(+)-, (2S,3S)-(+)-, (2R,3S)-(-)-, and (2R,3R)-(-)-cyproconazole was 
      simulated with molecular docking. The enantiomers were completely separated 
      primarily via halogen bond and hydrogen bond interactions with the chiral 
      stationary phases. The mean recoveries of the cyproconazole enantiomers in the 
      four matrices were 71.8-102.0% with intraday relative standard deviations (RSDs) 
      of 0.3-11.9% and interday RSDs of 0.9-10.6%. The results showed the chiral 
      recognition mechanism clearly and confirmed that the method was accurate and 
      convenient for the simultaneous detection of cyproconazole enantiomers in 
      environmental and food matrices.
FAU - He, Zongzhe
AU  - He Z
AD  - Department of Pesticide Science, College of Plant Protection, Nanjing 
      Agricultural University, State & Local Joint Engineering Research Center of Green 
      Pesticide Invention and Application, Nanjing 210095, China. wangmha@njau.edu.cn.
FAU - Wu, Fengxu
AU  - Wu F
AD  - College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, 
      China.
FAU - Xia, Weitong
AU  - Xia W
AD  - Department of Pesticide Science, College of Plant Protection, Nanjing 
      Agricultural University, State & Local Joint Engineering Research Center of Green 
      Pesticide Invention and Application, Nanjing 210095, China. wangmha@njau.edu.cn.
FAU - Li, Lianshan
AU  - Li L
AD  - Department of Pesticide Science, College of Plant Protection, Nanjing 
      Agricultural University, State & Local Joint Engineering Research Center of Green 
      Pesticide Invention and Application, Nanjing 210095, China. wangmha@njau.edu.cn.
FAU - Hu, Kunming
AU  - Hu K
AD  - Department of Pesticide Science, College of Plant Protection, Nanjing 
      Agricultural University, State & Local Joint Engineering Research Center of Green 
      Pesticide Invention and Application, Nanjing 210095, China. wangmha@njau.edu.cn.
FAU - Kaziem, Amir E
AU  - Kaziem AE
AD  - Department of Pesticide Science, College of Plant Protection, Nanjing 
      Agricultural University, State & Local Joint Engineering Research Center of Green 
      Pesticide Invention and Application, Nanjing 210095, China. wangmha@njau.edu.cn.
FAU - Wang, Minghua
AU  - Wang M
AUID- ORCID: 0000-0001-5715-4981
AD  - Department of Pesticide Science, College of Plant Protection, Nanjing 
      Agricultural University, State & Local Joint Engineering Research Center of Green 
      Pesticide Invention and Application, Nanjing 210095, China. wangmha@njau.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190726
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
SB  - IM
EDAT- 2019/07/28 06:00
MHDA- 2019/07/28 06:01
CRDT- 2019/07/27 06:00
PHST- 2019/07/28 06:00 [pubmed]
PHST- 2019/07/28 06:01 [medline]
PHST- 2019/07/27 06:00 [entrez]
AID - 10.1039/c9an00950g [doi]
PST - ppublish
SO  - Analyst. 2019 Sep 7;144(17):5193-5200. doi: 10.1039/c9an00950g. Epub 2019 Jul 26.