PMID- 31348053
OWN - NLM
STAT- MEDLINE
DCOM- 20201116
LR  - 20210126
IS  - 1526-7598 (Electronic)
IS  - 0003-2999 (Linking)
VI  - 131
IP  - 3
DP  - 2020 Sep
TI  - Two-Week Multimodal Prehabilitation Program Improves Perioperative Functional 
      Capability in Patients Undergoing Thoracoscopic Lobectomy for Lung Cancer: A 
      Randomized Controlled Trial.
PG  - 840-849
LID - 10.1213/ANE.0000000000004342 [doi]
AB  - BACKGROUND: Patients with lung cancer often experience reduced functional 
      capacity and quality of life after surgery. The current study investigated the 
      impact of a short-term, home-based, multimodal prehabilitation program on 
      perioperative functional capacity in patients undergoing video-assisted 
      thoracoscopic surgery (VATS) lobectomy for nonsmall cell lung cancer (NSCLC). 
      METHODS: A randomized controlled trial was conducted with 73 patients. Patients 
      in the prehabilitation group (n = 37) received a 2-week multimodal intervention 
      program before surgery, including aerobic and resistance exercises, respiratory 
      training, nutrition counseling with whey protein supplementation, and 
      psychological guidance. Patients in the control group (n = 36) received the usual 
      clinical care. The assessors were blinded to the patient allocation. The primary 
      outcome was perioperative functional capacity measured as the 6-minute walk 
      distance (6MWD), which was assessed at 1 day before and 30 days after surgery. A 
      linear mixed-effects model was built to analyze the perioperative 6MWD. Other 
      outcomes included lung function, disability and psychometric evaluations, length 
      of stay (LOS), short-term recovery quality, postoperative complications, and 
      mortality. RESULTS: The median duration of prehabilitation was 15 days. The 
      average 6MWD was 60.9 m higher perioperatively in the prehabilitation group 
      compared to the control group (95% confidence interval [CI], 32.4-89.5; P < 
      .001). There were no differences in lung function, disability and psychological 
      assessment, LOS, short-term recovery quality, postoperative complications, and 
      mortality, except for forced vital capacity (FVC; 0.35 L higher in the 
      prehabilitation group, 95% CI, 0.05-0.66; P = .021). CONCLUSIONS: A 2-week, 
      home-based, multimodal prehabilitation program could produce clinically relevant 
      improvements in perioperative functional capacity in patients undergoing VATS 
      lobectomy for lung cancer.
FAU - Liu, Zijia
AU  - Liu Z
AD  - From the Department of Anesthesiology, Peking Union Medical College Hospital, 
      Beijing, China.
FAU - Qiu, Tian
AU  - Qiu T
AD  - From the Department of Anesthesiology, Peking Union Medical College Hospital, 
      Beijing, China.
FAU - Pei, Lijian
AU  - Pei L
AD  - From the Department of Anesthesiology, Peking Union Medical College Hospital, 
      Beijing, China.
FAU - Zhang, Yuelun
AU  - Zhang Y
AD  - Central Research Laboratory, Peking Union Medical College Hospital, Beijing, 
      China.
FAU - Xu, Li
AU  - Xu L
AD  - From the Department of Anesthesiology, Peking Union Medical College Hospital, 
      Beijing, China.
FAU - Cui, Yushang
AU  - Cui Y
AD  - Departments of Thoracic Surgery.
FAU - Liang, Naixin
AU  - Liang N
AD  - Departments of Thoracic Surgery.
FAU - Li, Shanqing
AU  - Li S
AD  - Departments of Thoracic Surgery.
FAU - Chen, Wei
AU  - Chen W
AD  - Enteral and Parenteral Nutrition, Peking Union Medical College Hospital, Beijing, 
      China.
FAU - Huang, Yuguang
AU  - Huang Y
AD  - From the Department of Anesthesiology, Peking Union Medical College Hospital, 
      Beijing, China.
LA  - eng
SI  - ClinicalTrials.gov/NCT03068507
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Anesth Analg
JT  - Anesthesia and analgesia
JID - 1310650
RN  - 0 (Whey Proteins)
SB  - IM
CIN - J Thorac Dis. 2019 Dec;11(12):5664-5665. PMID: 32030295
CIN - J Thorac Dis. 2020 Apr;12(4):1628-1631. PMID: 32395302
MH  - Aged
MH  - Beijing
MH  - Breathing Exercises
MH  - Carcinoma, Non-Small-Cell Lung/*surgery
MH  - *Cardiorespiratory Fitness
MH  - Counseling
MH  - Dietary Supplements
MH  - Exercise Tolerance
MH  - Female
MH  - Health Status
MH  - *Home Care Services, Hospital-Based
MH  - Humans
MH  - Lung Neoplasms/*surgery
MH  - Male
MH  - Middle Aged
MH  - *Nutritional Status
MH  - Pneumonectomy/adverse effects/*rehabilitation
MH  - Postoperative Complications/prevention & control
MH  - *Preoperative Care
MH  - Recovery of Function
MH  - Relaxation Therapy
MH  - Resistance Training
MH  - Single-Blind Method
MH  - Thoracic Surgery, Video-Assisted/adverse effects/*rehabilitation
MH  - Time Factors
MH  - Treatment Outcome
MH  - Whey Proteins/administration & dosage
EDAT- 2019/07/28 06:00
MHDA- 2020/11/18 06:00
CRDT- 2019/07/27 06:00
PHST- 2019/07/28 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2019/07/27 06:00 [entrez]
AID - 00000539-202009000-00026 [pii]
AID - 10.1213/ANE.0000000000004342 [doi]
PST - ppublish
SO  - Anesth Analg. 2020 Sep;131(3):840-849. doi: 10.1213/ANE.0000000000004342.