PMID- 31348311
OWN - NLM
STAT- MEDLINE
DCOM- 20190813
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 30
DP  - 2019 Jul
TI  - Efficacy and safety of eradication therapy for elderly patients with helicobacter 
      pylori infection.
PG  - e16619
LID - 10.1097/MD.0000000000016619 [doi]
LID - e16619
AB  - Helicobacter pylori (H. pylori) is the most prevalent chronic bacterial infection 
      and is associated with chronic gastritis, peptic ulcer disease, and gastric 
      adenocarcinoma. Although eradication therapy is widely performed for H. pylori 
      infection, adverse events (AEs) are of particular concern in the elderly. This 
      study investigated the efficacy and safety of H. pylori eradication therapy for 
      elderly patients.Retrospective investigation of 1271 cases (median age: 61 years, 
      730 male) of H. pylori infection was performed to compare clinical indications 
      and outcomes among the younger group (<65 years old), elderly group (65-74 years 
      old), and super-elderly group (>75 years old).Chronic gastritis (77.0%) and 
      gastric and/or duodenal ulcer (16.4%) were the most frequent indications for 
      eradication therapy in the cohort. The respective eradication and AE rates for 
      the first and second treatment regimens were 92.1% (1044 of 1133 cases) and 9.1% 
      (103 of 1133 cases) and 84.2% (123 of 146 cases) and 8.9% (13 of 146 cases). No 
      significant differences were detected for eradication rate or AE frequency 
      between the super-elderly group and the other groups. Prior to therapy, the 
      super-elderly group had significantly less frequent chronic gastritis than the 
      other groups but more frequent gastric or duodenal ulcer and post-gastric cancer 
      treatment (all P < .001), indicating a reluctance for clinicians to treat very 
      old patients, possibly due to unfounded concerns of complications.Triple therapy 
      for H. pylori eradication is effective and safe, even for elderly patients.
FAU - Kobayashi, Satoshi
AU  - Kobayashi S
AD  - Department of Gastroenterology, Hokushin General Hospital, Nagano Prefectural 
      Federation of Agricultural Cooperatives for Health and Welfare, Nakano.
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu 
      University School of Medicine.
FAU - Joshita, Satoru
AU  - Joshita S
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu 
      University School of Medicine.
AD  - Research Center for Next Generation Medicine, Shinshu University, Matsumoto, 
      Japan.
FAU - Yamamoto, Chikara
AU  - Yamamoto C
AD  - Department of Gastroenterology, Hokushin General Hospital, Nagano Prefectural 
      Federation of Agricultural Cooperatives for Health and Welfare, Nakano.
FAU - Yanagisawa, Takumi
AU  - Yanagisawa T
AD  - Department of Gastroenterology, Hokushin General Hospital, Nagano Prefectural 
      Federation of Agricultural Cooperatives for Health and Welfare, Nakano.
FAU - Miyazawa, Takayuki
AU  - Miyazawa T
AD  - Department of Gastroenterology, Hokushin General Hospital, Nagano Prefectural 
      Federation of Agricultural Cooperatives for Health and Welfare, Nakano.
FAU - Miyazawa, Megumi
AU  - Miyazawa M
AD  - Department of Gastroenterology, Hokushin General Hospital, Nagano Prefectural 
      Federation of Agricultural Cooperatives for Health and Welfare, Nakano.
FAU - Kubota, Daisuke
AU  - Kubota D
AD  - Department of Gastroenterology, Hokushin General Hospital, Nagano Prefectural 
      Federation of Agricultural Cooperatives for Health and Welfare, Nakano.
FAU - Sato, Junichi
AU  - Sato J
AD  - Department of Gastroenterology, Hokushin General Hospital, Nagano Prefectural 
      Federation of Agricultural Cooperatives for Health and Welfare, Nakano.
FAU - Umemura, Takeji
AU  - Umemura T
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu 
      University School of Medicine.
AD  - Research Center for Next Generation Medicine, Shinshu University, Matsumoto, 
      Japan.
FAU - Tanaka, Eiji
AU  - Tanaka E
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Shinshu 
      University School of Medicine.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aging
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Chronic Disease
MH  - Drug Therapy, Combination
MH  - Female
MH  - Gastritis/etiology
MH  - Helicobacter Infections/complications/*drug therapy
MH  - Helicobacter pylori
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptic Ulcer/etiology
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Retrospective Studies
PMC - PMC6709141
COIS- Conflicts of interest: The authors declare no conflicts of interest.
EDAT- 2019/07/28 06:00
MHDA- 2019/08/14 06:00
PMCR- 2019/07/26
CRDT- 2019/07/27 06:00
PHST- 2019/07/27 06:00 [entrez]
PHST- 2019/07/28 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
PHST- 2019/07/26 00:00 [pmc-release]
AID - 00005792-201907260-00086 [pii]
AID - MD-D-19-02120 [pii]
AID - 10.1097/MD.0000000000016619 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Jul;98(30):e16619. doi: 10.1097/MD.0000000000016619.