PMID- 31349032
OWN - NLM
STAT- MEDLINE
DCOM- 20200727
LR  - 20210110
IS  - 1095-953X (Electronic)
IS  - 0969-9961 (Print)
IS  - 0969-9961 (Linking)
VI  - 132
DP  - 2019 Dec
TI  - Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are 
      putative predictors of neuritic plaque and neurofibrillary tangle pathology.
PG  - 104540
LID - S0969-9961(19)30208-6 [pii]
LID - 10.1016/j.nbd.2019.104540 [doi]
AB  - INTRODUCTION: Downregulation of brain-derived neurotrophic factor (BDNF) and its 
      cognate neurotrophin receptor, TrkB, were observed during the progression of 
      dementia, but whether the Alzheimer's disease (AD) pathological lesions diffuse 
      plaques, (DPs), neuritic plaques (NPs), and neurofibrillary tangles (NFTs) are 
      related to this alteration remains to be clarified. METHODS: Negative binomial 
      (NB) regressions were performed using gene expression data accrued from a single 
      population of CA1 pyramidal neurons and regional hippocampal dissections obtained 
      from participants in the Rush Religious Orders Study (RROS). RESULTS: 
      Downregulation of Bdnf is independently associated with increased entorhinal 
      cortex NPs. Downregulation of TrkB is independently associated with increased 
      entorhinal cortex NFTs and CA1 NPs during the progression of AD. DISCUSSION: 
      Results indicate that BDNF and TrkB dysregulation contribute to AD 
      neuropathology, most notably hippocampal NPs and NFTs. These data suggest 
      attenuating BDNF/TrkB signaling deficits either at the level of BDNF, TrkB, or 
      downstream of TrkB signaling may abrogate NPs and/or NFTs.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Ginsberg, Stephen D
AU  - Ginsberg SD
AD  - Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, United 
      States of America; Department of Psychiatry, New York University Langone Medical 
      Center, New York, NY, United States of America; Department of Neuroscience & 
      Physiology, New York University Langone Medical Center, New York, NY, United 
      States of America; NYU Neuroscience Institute, New York University Langone 
      Medical Center, New York, NY, United States of America. Electronic address: 
      ginsberg@nki.rfmh.org.
FAU - Malek-Ahmadi, Michael H
AU  - Malek-Ahmadi MH
AD  - Banner Alzheimer's Institute, Phoenix, AZ, United States of America.
FAU - Alldred, Melissa J
AU  - Alldred MJ
AD  - Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, United 
      States of America; Department of Psychiatry, New York University Langone Medical 
      Center, New York, NY, United States of America.
FAU - Chen, Yinghua
AU  - Chen Y
AD  - Banner Alzheimer's Institute, Phoenix, AZ, United States of America.
FAU - Chen, Kewei
AU  - Chen K
AD  - Banner Alzheimer's Institute, Phoenix, AZ, United States of America.
FAU - Chao, Moses V
AU  - Chao MV
AD  - Department of Psychiatry, New York University Langone Medical Center, New York, 
      NY, United States of America; NYU Neuroscience Institute, New York University 
      Langone Medical Center, New York, NY, United States of America; Skirball 
      Institute of Biomolecular Medicine, New York University Langone Medical Center, 
      New York, NY, United States of America.
FAU - Counts, Scott E
AU  - Counts SE
AD  - Department of Translational Science and Molecular Medicine, Michigan State 
      University, Grand Rapids, MI, United States of America; Department of Family 
      Medicine, Michigan State University, East Lansing, MI, United States of America; 
      Michigan Alzheimer's Disease Core Center, Ann Arbor, MI, United States of 
      America; Hauenstein Neurosciences Center, Mercy Health Saint Mary's Hospital, 
      Grand Rapids, MI, United States of America.
FAU - Mufson, Elliott J
AU  - Mufson EJ
AD  - Department of Neurobiology and Neurology, Barrow Neurological Institute, Phoenix, 
      AZ, United States of America.
LA  - eng
GR  - R01 AG025970/AG/NIA NIH HHS/United States
GR  - P01 AG017617/AG/NIA NIH HHS/United States
GR  - R01 AG043375/AG/NIA NIH HHS/United States
GR  - R01 NS021072/NS/NINDS NIH HHS/United States
GR  - P30 AG010161/AG/NIA NIH HHS/United States
GR  - P01 AG014449/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190723
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (tropomyosin-related kinase-B, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/genetics/metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/genetics
MH  - Female
MH  - Gene Expression
MH  - Hippocampus/*metabolism/pathology
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*biosynthesis/genetics
MH  - Neurofibrillary Tangles/genetics/*metabolism/pathology
MH  - Plaque, Amyloid/genetics/*metabolism/pathology
MH  - Predictive Value of Tests
MH  - Receptor, trkB/*biosynthesis/genetics
PMC - PMC6834890
MID - NIHMS1536395
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Brain-derived neurotrophic factor
OT  - Microarray
OT  - Mild cognitive impairment
OT  - Negative binomial model
OT  - Neuritic plaques
OT  - Neurofibrillary tangles
OT  - TrkB
EDAT- 2019/07/28 06:00
MHDA- 2020/07/28 06:00
PMCR- 2020/12/01
CRDT- 2019/07/27 06:00
PHST- 2019/03/13 00:00 [received]
PHST- 2019/07/17 00:00 [revised]
PHST- 2019/07/22 00:00 [accepted]
PHST- 2019/07/28 06:00 [pubmed]
PHST- 2020/07/28 06:00 [medline]
PHST- 2019/07/27 06:00 [entrez]
PHST- 2020/12/01 00:00 [pmc-release]
AID - S0969-9961(19)30208-6 [pii]
AID - 10.1016/j.nbd.2019.104540 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2019 Dec;132:104540. doi: 10.1016/j.nbd.2019.104540. Epub 2019 Jul 
      23.