PMID- 31349487
OWN - NLM
STAT- MEDLINE
DCOM- 20191230
LR  - 20191230
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 103
DP  - 2019 Oct
TI  - Manufacturing and characterization of plates for fracture fixation of bone with 
      biocomposites of poly (lactic acid-co-glycolic acid) (PLGA) with calcium 
      phosphates bioceramics.
PG  - 109728
LID - S0928-4931(18)33078-9 [pii]
LID - 10.1016/j.msec.2019.05.013 [doi]
AB  - Commercially, there are several plates and screws for bone fracture fixation made 
      with PLA, however, its long degradation time and lack of integration with bone 
      structure, provides interest in research using polymers with faster degradation, 
      such as PLGA, and together with bioceramics, in order to improve bioactivity in 
      bone regeneration. Based on this, in this study, bone fracture fixation plates 
      composed of PLGA polymer matrix and combinations of 5 and 10%wt. of bioceramics 
      were processed by microinjection. The bioceramics used comprehend nanostructured 
      hydroxyapatite (n-HA), beta-tricalcium phosphate (beta-TCP) and calcium phosphate with 
      ion substitution of magnesium (Mg-Ca/P) and strontium (Sr-Ca/P). The introduction 
      of bioceramics modified thermal and mechanical properties of the polymer. The TGA 
      analysis showed that there was a variation on the ceramic's mass inserted in 
      relation to the expected values (5% and 10%wt.) in all groups of biocomposites. 
      In general, Tg values obtained by DMA were slightly increased in almost all the 
      biocomposites. The storage modulus (E') of biocomposites was higher for almost 
      all groups of inserted ceramics, with exception of 5%n-HA. In the flexural tests, 
      the biocomposites obtained a great dispersion in average values of fracture 
      loading, presented lower values in relation to pure PLGA. There were difficulties 
      in the processing of biocomposites with Mg-Ca/P and Sr-Ca/P, a factor that can be 
      attributed to lack of homogeneity in the material mixing process. The results 
      suggest modifications in thermal and mechanical properties of the PLGA plates 
      with the bioceramics insertion and provide improvement understanding about of 
      manufactured composites with PLGA and bioceramics.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Dos Santos, Thaiane Maria Balestreri Knopf
AU  - Dos Santos TMBK
AD  - CERMAT, Mechanical Engineering Department, Federal University of Santa Catarina - 
      UFSC, Florianopolis, SC, Brazil. Electronic address: thaianebks@gmail.com.
FAU - Merlini, Claudia
AU  - Merlini C
AD  - Engineering Department, Federal University of Santa Catarina - UFSC, Blumenau, 
      SC, Brazil.
FAU - Aragones, Aguedo
AU  - Aragones A
AD  - Odontology Department, Federal University of Santa Catarina - UFSC, 
      Florianopolis, SC, Brazil.
FAU - Fredel, Marcio Celso
AU  - Fredel MC
AD  - CERMAT, Mechanical Engineering Department, Federal University of Santa Catarina - 
      UFSC, Florianopolis, SC, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20190508
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Calcium Phosphates)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
SB  - IM
MH  - Animals
MH  - *Bone Plates
MH  - Calcium Phosphates/*chemistry
MH  - Ceramics/*chemistry
MH  - *Fracture Fixation
MH  - Fractures, Bone/*therapy
MH  - Humans
MH  - Polylactic Acid-Polyglycolic Acid Copolymer/*chemistry
EDAT- 2019/07/28 06:00
MHDA- 2019/12/31 06:00
CRDT- 2019/07/28 06:00
PHST- 2018/10/09 00:00 [received]
PHST- 2019/03/02 00:00 [revised]
PHST- 2019/05/07 00:00 [accepted]
PHST- 2019/07/28 06:00 [entrez]
PHST- 2019/07/28 06:00 [pubmed]
PHST- 2019/12/31 06:00 [medline]
AID - S0928-4931(18)33078-9 [pii]
AID - 10.1016/j.msec.2019.05.013 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109728. doi: 
      10.1016/j.msec.2019.05.013. Epub 2019 May 8.