PMID- 31349845
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200225
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Jul 26
TI  - Investigating the risk of bone fractures in elderly patients with type 2 diabetes 
      mellitus: a retrospective study.
PG  - 81
LID - 10.1186/s12902-019-0413-0 [doi]
LID - 81
AB  - BACKGROUND: Elderly patients with type 2 diabetes mellitus (T2DM) experience 
      fractures more frequently than elderly individuals without diabetes. Fractures 
      requiring hospitalization greatly affect quality of life, and although elderly 
      patients with T2DM have several risk factors associated with fractures, only a 
      few studies have evaluated these in detail in the Asian population. We conducted 
      a retrospective study of elderly patients with T2DM for evaluating factors 
      associated with fracture risk. METHODS: We conducted a retrospective study using 
      electronic medical records (EMR) of patients aged >/=65 years with T2DM who were 
      admitted to a public general medical institute in central Tokyo, Japan. We 
      evaluated factors associated with fractures necessitating hospitalization in 
      elderly patients with T2DM characteristics and hypoglycemic agent use. Factors 
      associated with fracture risk were identified using multivariable logistic 
      regression analysis. RESULTS: A total of 2,112 elderly patients (age >/= 65 years) 
      with T2DM were analyzed. Among them, 69 (3.3%) patients had been hospitalized for 
      fractures. Factors associated with fractures were female sex (OR, 3.46), eGFR 
      < 60 ml / min / 1.73 m(2) (OR, 0.55), and thiazolidine use (OR, 4.28). Further, a 
      separate analysis based on sex revealed that the use of thiazolidines was 
      significantly associated with fracture risk in both sexes. CONCLUSIONS: In 
      elderly patients with T2DM, the key factor associated with fractures was the use 
      of thiazolidines in both males and females. In this study, the use of 
      thiazolidines was newly identified as a factor which increased the risk of 
      fractures requiring hospitalization in elderly males. The study findings should 
      be considered when hypoglycemic agents are selected for treating elderly patients 
      with T2DM. Information bias, selection bias, and the effect of concomitant drugs 
      may be the underlying reasons for why eGFR < 60 mL / min / 1.73 m(2) reduced the 
      fracture risk. However, details are unknown, and additional investigations are 
      needed.
FAU - Horii, Takeshi
AU  - Horii T
AD  - Division of Clinical Pharmacy (Pharmacy Practice and Science I) and Research and 
      Education Center for Clinical Pharmacy, Kitasato University School of Pharmacy, 
      1-15-1 Kitasato, Minami Ward, Sagamihara City, Kanagawa Prefecture, 252-0375, 
      Japan. horiit@pharm.kitasato-u.ac.jp.
FAU - Iwasawa, Makiko
AU  - Iwasawa M
AD  - Division of Clinical Pharmacy (Laboratory of Drug Information) and Research and 
      Education Center for Clinical Pharmacy, Kitasato University School of Pharmacy, 
      1-15-1 Kitasato, Minami Ward, Sagamihara City, Kanagawa Prefecture, 252-0375, 
      Japan.
FAU - Kabeya, Yusuke
AU  - Kabeya Y
AD  - Home Medical Care Department, Sowa Hospital, 1752 Oshima, Midori Ward, Sagamihara 
      City, Kanagawa Prefecture, 252-0135, Japan.
FAU - Shimizu, Jyunichi
AU  - Shimizu J
AD  - Department of Pharmacy, Tokyo Saiseikai Central Hospital, 1-4-17 Mita, Minato 
      Ward, Tokyo, 108-0073, Japan.
FAU - Atsuda, Koichiro
AU  - Atsuda K
AD  - Division of Clinical Pharmacy (Pharmacy Practice and Science I) and Research and 
      Education Center for Clinical Pharmacy, Kitasato University School of Pharmacy, 
      1-15-1 Kitasato, Minami Ward, Sagamihara City, Kanagawa Prefecture, 252-0375, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20190726
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Follow-Up Studies
MH  - Fractures, Bone/*etiology/pathology
MH  - Hospitalization/*statistics & numerical data
MH  - Humans
MH  - Japan
MH  - Male
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC6660921
OTO - NOTNLM
OT  - Antihyperglycemic agents
OT  - Bone fractures
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests.
EDAT- 2019/07/28 06:00
MHDA- 2020/01/07 06:00
PMCR- 2019/07/26
CRDT- 2019/07/28 06:00
PHST- 2019/04/25 00:00 [received]
PHST- 2019/07/19 00:00 [accepted]
PHST- 2019/07/28 06:00 [entrez]
PHST- 2019/07/28 06:00 [pubmed]
PHST- 2020/01/07 06:00 [medline]
PHST- 2019/07/26 00:00 [pmc-release]
AID - 10.1186/s12902-019-0413-0 [pii]
AID - 413 [pii]
AID - 10.1186/s12902-019-0413-0 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2019 Jul 26;19(1):81. doi: 10.1186/s12902-019-0413-0.