PMID- 31350461
OWN - NLM
STAT- MEDLINE
DCOM- 20201102
LR  - 20240216
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Jul 26
TI  - Methylmercury exposure, genetic variation in metabolic enzymes, and the risk of 
      glioma.
PG  - 10861
LID - 10.1038/s41598-019-47284-4 [doi]
LID - 10861
AB  - Methylmercury (MeHg) is an environmental neurotoxin with human exposure mainly 
      from dietary intake of contaminated fish. Exposure to MeHg has been implicated in 
      neurological damage, but research on its role in cancers, specifically glioma, is 
      limited. In a glioma case-control study, we examined associations between toenail 
      mercury (Hg) and glioma risk. We also examined genetic polymorphisms in 13 genes 
      related to MeHg metabolism for association with glioma risk; genetic associations 
      were also studied in the UK Biobank cohort. Median toenail Hg in cases and 
      controls, respectively, was 0.066 mug/g and 0.069 mug/g (interquartile range (IQR): 
      0.032-0.161 and 0.031-0.150 mug/g). Toenail Hg was not found to be significantly 
      associated with glioma risk (Odds Ratio: 1.02; 95% Confidence Interval: 0.91, 
      1.14; p = 0.70 in analysis for ordinal trend with increasing quartile of toenail 
      MeHg). No genetic variant was statistically significant in both of the studies; 
      one variant, rs11859163 (MMP2) had a combined p-value of 0.02 though it was no 
      longer significant after adjustment for multiple testing (Bonferroni corrected 
      p = 1). This study does not support the hypothesis that exposure to MeHg plays a 
      role in the development of glioma at levels of exposure found in this study 
      population.
FAU - Creed, Jordan H
AU  - Creed JH
AD  - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research 
      Institute, Inc., Tampa, FL, 33612, USA.
FAU - Peeri, Noah C
AU  - Peeri NC
AD  - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research 
      Institute, Inc., Tampa, FL, 33612, USA.
FAU - Anic, Gabriella M
AU  - Anic GM
AD  - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research 
      Institute, Inc., Tampa, FL, 33612, USA.
FAU - Thompson, Reid C
AU  - Thompson RC
AD  - Department of Neurological Surgery, Vanderbilt University Medical Center, 
      Nashville, TN, 37232, USA.
FAU - Olson, Jeffrey J
AU  - Olson JJ
AD  - Department of Neurosurgery, Emory School of Medicine, Atlanta, GA, 30322, USA.
FAU - LaRocca, Renato V
AU  - LaRocca RV
AD  - Norton Cancer Institute, Louisville, KY, 40202, USA.
FAU - Chowdhary, Sajeel A
AU  - Chowdhary SA
AD  - Neuro-Oncology Program, Lynn Cancer Institute, 701 NW 13th Street, Boca Raton, 
      FL, 33486, USA.
FAU - Brockman, John D
AU  - Brockman JD
AD  - University of Missouri Research Reactor, University of Missouri, Columbia, MO, 
      65211, USA.
FAU - Gerke, Travis A
AU  - Gerke TA
AD  - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research 
      Institute, Inc., Tampa, FL, 33612, USA.
FAU - Nabors, Louis B
AU  - Nabors LB
AUID- ORCID: 0000-0001-5926-2230
AD  - Neuro-oncology Program, University of Alabama at Birmingham, Birmingham, AL, 
      35294, USA.
FAU - Egan, Kathleen M
AU  - Egan KM
AD  - Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research 
      Institute, Inc., Tampa, FL, 33612, USA. kathleen.egan@moffitt.org.
LA  - eng
GR  - R01 CA116174/CA/NCI NIH HHS/United States
GR  - MC_PC_17228/MRC_/Medical Research Council/United Kingdom
GR  - P30 CA076292/CA/NCI NIH HHS/United States
GR  - R03 CA173798/CA/NCI NIH HHS/United States
GR  - MC_QA137853/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20190726
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Methylmercury Compounds)
RN  - EC 3.4.24.24 (MMP2 protein, human)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - FXS1BY2PGL (Mercury)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Neoplasms/*epidemiology
MH  - Case-Control Studies
MH  - Dietary Exposure
MH  - Female
MH  - Glioma/*epidemiology
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 2/*genetics/metabolism
MH  - Mercury/*analysis
MH  - Methylmercury Compounds/analysis/*metabolism
MH  - Middle Aged
MH  - Nails/chemistry
MH  - *Polymorphism, Single Nucleotide
MH  - Prospective Studies
MH  - Risk Factors
MH  - United Kingdom/epidemiology
MH  - United States/epidemiology
MH  - Young Adult
PMC - PMC6659774
COIS- The authors declare no competing interests.
EDAT- 2019/07/28 06:00
MHDA- 2020/11/03 06:00
PMCR- 2019/07/26
CRDT- 2019/07/28 06:00
PHST- 2018/10/05 00:00 [received]
PHST- 2019/07/15 00:00 [accepted]
PHST- 2019/07/28 06:00 [entrez]
PHST- 2019/07/28 06:00 [pubmed]
PHST- 2020/11/03 06:00 [medline]
PHST- 2019/07/26 00:00 [pmc-release]
AID - 10.1038/s41598-019-47284-4 [pii]
AID - 47284 [pii]
AID - 10.1038/s41598-019-47284-4 [doi]
PST - epublish
SO  - Sci Rep. 2019 Jul 26;9(1):10861. doi: 10.1038/s41598-019-47284-4.