PMID- 31350848
OWN - NLM
STAT- MEDLINE
DCOM- 20200928
LR  - 20200928
IS  - 1529-7268 (Electronic)
IS  - 0006-3363 (Linking)
VI  - 101
IP  - 4
DP  - 2019 Oct 25
TI  - Pattern recognition receptor-mediated innate immune responses in seminal vesicle 
      epithelial cell and their impacts on cellular functiondagger.
PG  - 733-747
LID - 10.1093/biolre/ioz136 [doi]
AB  - The seminal vesicles can be infected by microorganisms, thereby resulting in 
      vesiculitis and impairment in male fertility. Innate immune responses in seminal 
      vesicles cells to microbial infections, which facilitate vesiculitis, have yet to 
      be investigated. The present study aims to elucidate pattern recognition 
      receptor-mediated innate immune responses in seminal vesicles epithelial cells. 
      Various pattern recognition receptors, including Toll-like receptor 3, Toll-like 
      receptor 4, cytosolic ribonucleic acid, and deoxyribonucleic acid sensors, are 
      abundantly expressed in seminal vesicles epithelial cells. These pattern 
      recognition receptors can recognize their respective ligands, thus activating 
      nuclear factor kappa B and interferon regulatory factor 3. The pattern 
      recognition receptor signaling induces expression of pro-inflammatory cytokines, 
      such as tumor necrosis factor alpha (Tnfa) and interleukin 6 (Il6), chemokines 
      monocyte chemoattractant protein-1 (Mcp1) and C-X-C motif chemokine 10 (Cxcl10), 
      and type 1 interferons Ifna and Ifnb. Moreover, pattern recognition 
      receptor-mediated innate immune responses up-regulated the expression of 
      microsomal prostaglandin E synthase and cyclooxygenase 2, but they down-regulated 
      semenogelin-1 expression. These results provide novel insights into the mechanism 
      underlying vesiculitis and its impact on the functions of the seminal vesicles.
CI  - (c) The Author(s) 2019. Published by Oxford University Press on behalf of Society 
      for the Study of Reproduction. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Gong, Maolei
AU  - Gong M
AD  - Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School 
      of Basic Medicine, Peking Union Medical College, Beijing, China.
FAU - Wang, Fei
AU  - Wang F
AD  - Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School 
      of Basic Medicine, Peking Union Medical College, Beijing, China.
FAU - Liu, Weihua
AU  - Liu W
AD  - Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School 
      of Basic Medicine, Peking Union Medical College, Beijing, China.
FAU - Chen, Ran
AU  - Chen R
AD  - Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School 
      of Basic Medicine, Peking Union Medical College, Beijing, China.
FAU - Wu, Han
AU  - Wu H
AD  - Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School 
      of Basic Medicine, Peking Union Medical College, Beijing, China.
FAU - Zhang, Wenjing
AU  - Zhang W
AD  - Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School 
      of Basic Medicine, Peking Union Medical College, Beijing, China.
FAU - Yu, Xiaoqin
AU  - Yu X
AD  - Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School 
      of Basic Medicine, Peking Union Medical College, Beijing, China.
FAU - Han, Ruiqin
AU  - Han R
AD  - Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School 
      of Basic Medicine, Peking Union Medical College, Beijing, China.
FAU - Liu, Aijie
AU  - Liu A
AD  - Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School 
      of Basic Medicine, Peking Union Medical College, Beijing, China.
FAU - Chen, Yongmei
AU  - Chen Y
AD  - Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School 
      of Basic Medicine, Peking Union Medical College, Beijing, China.
FAU - Han, Daishu
AU  - Han D
AD  - Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School 
      of Basic Medicine, Peking Union Medical College, Beijing, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biol Reprod
JT  - Biology of reproduction
JID - 0207224
RN  - 0 (Receptors, Pattern Recognition)
RN  - O84C90HH2L (Poly I-C)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Epithelial Cells/cytology/*immunology/metabolism
MH  - Immunity, Innate/*genetics
MH  - Inflammation/genetics/immunology/pathology
MH  - Male
MH  - Mice
MH  - Mice, 129 Strain
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Poly I-C
MH  - Receptors, Pattern Recognition/genetics/*physiology
MH  - Seminal Vesicles/cytology/*immunology/metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - innate immune response
OT  - male infertility
OT  - pattern recognition pattern receptor
OT  - seminal vesicle
OT  - vesiculitis
EDAT- 2019/07/28 06:00
MHDA- 2020/09/29 06:00
CRDT- 2019/07/28 06:00
PHST- 2019/02/17 00:00 [received]
PHST- 2019/05/29 00:00 [revised]
PHST- 2019/07/26 00:00 [accepted]
PHST- 2019/07/28 06:00 [pubmed]
PHST- 2020/09/29 06:00 [medline]
PHST- 2019/07/28 06:00 [entrez]
AID - 5539733 [pii]
AID - 10.1093/biolre/ioz136 [doi]
PST - ppublish
SO  - Biol Reprod. 2019 Oct 25;101(4):733-747. doi: 10.1093/biolre/ioz136.