PMID- 31351475
OWN - NLM
STAT- MEDLINE
DCOM- 20200218
LR  - 20200225
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 14
IP  - 1
DP  - 2019 Jul 27
TI  - Multinucleated stromal giant cells in the gastroesophageal junctional and gastric 
      mucosa: a retrospective study.
PG  - 83
LID - 10.1186/s13000-019-0860-y [doi]
LID - 83
AB  - BACKGROUND: Atypical multinucleated stromal giant cells (MSGCs) are occasionally 
      encountered in the esophagogastric mucosa. This study aims to investigate the 
      origin and clinical association of MSGCs in the upper gastrointestinal tract. 
      METHODS: Three hundred sixty-one contiguous biopsies and 1 resection specimen 
      from the stomach and gastroesophageal junction (GEJ) were identified from 
      archives for morphologic and immunohistochemical studies. RESULTS: MSGCs were 
      identified in 22 cases (6%: 7 gastric, 15 GEJ). Patients' average age was 
      53 years. There was no sex predilection. 77% cases had only 1 or 2 MSGCs per 10 
      high power fields. MSGCs were located in the lamina propria of the gastric or GEJ 
      mucosa, with an accentuation in the subepithelial zone. The median number of 
      nuclei in a MSGC was 5 (ranging from 3 to 16). The nuclei were 
      touching/overlapping, often arranged into "wreath", "caterpillar", or "morula" 
      configurations. MSGCs expressed smooth muscle actin, desmin, while negative for 
      cytokeratin AE1/3, CD68, S100, chromogranin, and CD117. The most common clinical 
      history was epigastric pain, gastroesophageal reflux, and Barrett esophagus. The 
      most common associated pathologic diagnoses included reactive (chemical) 
      gastropathy (71% gastric biopsies) and gastroesophageal reflux (73% GEJ 
      specimens). CONCLUSIONS: MSGCs in the esophagogastric mucosa show smooth 
      muscle/myofibroblast differentiation by immunohistochemistry and likely represent 
      a reactive/reparative stromal reaction associated with gastroesophageal reflux 
      and reactive (chemical) gastropathy.
FAU - Sachak, Taha
AU  - Sachak T
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, S301 
      Rhodes Hall, 450 W. 10th Ave, Columbus, OH, 43210, USA.
FAU - Frankel, Wendy L
AU  - Frankel WL
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, S301 
      Rhodes Hall, 450 W. 10th Ave, Columbus, OH, 43210, USA.
FAU - Arnold, Christina A
AU  - Arnold CA
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, S301 
      Rhodes Hall, 450 W. 10th Ave, Columbus, OH, 43210, USA.
FAU - Chen, Wei
AU  - Chen W
AUID- ORCID: 0000-0002-9028-622X
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, S301 
      Rhodes Hall, 450 W. 10th Ave, Columbus, OH, 43210, USA. Wei.Chen2@osumc.edu.
LA  - eng
PT  - Journal Article
DEP - 20190727
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
SB  - IM
MH  - Adult
MH  - Barrett Esophagus/pathology
MH  - Biopsy
MH  - Esophagogastric Junction/*pathology
MH  - Female
MH  - Gastric Mucosa/*pathology
MH  - Gastroesophageal Reflux/*pathology
MH  - Giant Cells/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Stomach Diseases/pathology
PMC - PMC6661083
OTO - NOTNLM
OT  - Chemical gastropathy
OT  - Gastroesophageal reflux disease
OT  - Multinucleated stromal giant cells
OT  - Reactive changes
COIS- The authors declare that they have no competing interest.
EDAT- 2019/07/29 06:00
MHDA- 2020/02/19 06:00
PMCR- 2019/07/27
CRDT- 2019/07/29 06:00
PHST- 2019/05/23 00:00 [received]
PHST- 2019/07/10 00:00 [accepted]
PHST- 2019/07/29 06:00 [entrez]
PHST- 2019/07/29 06:00 [pubmed]
PHST- 2020/02/19 06:00 [medline]
PHST- 2019/07/27 00:00 [pmc-release]
AID - 10.1186/s13000-019-0860-y [pii]
AID - 860 [pii]
AID - 10.1186/s13000-019-0860-y [doi]
PST - epublish
SO  - Diagn Pathol. 2019 Jul 27;14(1):83. doi: 10.1186/s13000-019-0860-y.