PMID- 31351832
OWN - NLM
STAT- MEDLINE
DCOM- 20200402
LR  - 20200402
IS  - 1532-2165 (Electronic)
IS  - 1078-5884 (Linking)
VI  - 58
IP  - 3
DP  - 2019 Sep
TI  - A Randomised Controlled Trial Comparing Three Different Radiofrequency 
      Technologies: Short-Term Results of the 3-RF Trial.
PG  - 401-408
LID - S1078-5884(19)30107-8 [pii]
LID - 10.1016/j.ejvs.2019.01.033 [doi]
AB  - OBJECTIVE: To date there has been no comparison of outcomes of endovenous 
      radiofrequency (RF) devices. The 3-RF trial is the first randomised controlled 
      trial of three commercially available RF ablation technologies. METHODS: Patients 
      were recruited [182/302 patients with great saphenous vein (GSV) incompetence] 
      into a prospective double blind randomised trial of Venefit, radiofrequency 
      induced thermal therapy (RFITT), and endovenous radiofrequency (EVRF). The 
      primary outcome measure was GSV closure (total/partial/failed) at six months. 
      Secondary outcome measures included ablation times, complications, pain scores, 
      analgesia requirements, and quality of life (QoL) scores to 12 months. RESULTS: 
      Patients treated [180: Venefit (57), RFITT (64), EVRF (59)] were matched for age, 
      sex, and vein characteristics. At six months, complete GSV closure was 
      significantly better after Venefit and RFITT treatment (100% and 98%, 
      respectively) compared with EVRF treatment (79%, p < .001). Mean treatment time 
      was significantly faster for RFITT than for Venefit and EVRF (p < .0001). Euroqol 
      5D (EQ5D) visual analogue score (VAS) did not differ between groups at any time 
      point. The only difference between groups in EQ5D domain scores was for the 
      pain/discomfort domain at two weeks when significantly fewer EVRF patients 
      reported no problems compared with Venefit and RFITT. This difference had 
      disappeared at six and 12 months. The Aberdeen Varicose Vein Questionnaire (AVVQ) 
      improved for all groups at six and 12 months compared with pre-treatment levels; 
      however, there was no significant difference between groups. CONCLUSION: Compared 
      with Venefit and RFITT, EVRF was associated with significant failure of truncal 
      ablation at six months; however, clinical outcomes did not differ significantly 
      at 12 months. clinicaltrials.gov identifier: NCT02441881, NHS Health Research 
      Authority (Hampstead Research Ethics Committee) number: 14/LO/1232.
CI  - Copyright (c) 2019 European Society for Vascular Surgery. Published by Elsevier 
      B.V. All rights reserved.
FAU - Nyamekye, Isaac K
AU  - Nyamekye IK
AD  - Department of Vascular Surgery, Worcestershire Royal Hospital, Worcester, UK. 
      Electronic address: i.nyamekye@nhs.net.
FAU - Dattani, Nikesh
AU  - Dattani N
AD  - Department of Vascular Surgery, Worcestershire Royal Hospital, Worcester, UK.
FAU - Hayes, Wendy
AU  - Hayes W
AD  - Department of Vascular Surgery, Worcestershire Royal Hospital, Worcester, UK.
FAU - Harding, Daniel
AU  - Harding D
AD  - Department of Vascular Surgery, Worcestershire Royal Hospital, Worcester, UK.
FAU - Holloway, Sarah
AU  - Holloway S
AD  - Department of Vascular Surgery, Worcestershire Royal Hospital, Worcester, UK.
FAU - Newman, Jeremy
AU  - Newman J
AD  - Department of Vascular Surgery, Worcestershire Royal Hospital, Worcester, UK.
LA  - eng
SI  - ClinicalTrials.gov/NCT02441881
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20190724
PL  - England
TA  - Eur J Vasc Endovasc Surg
JT  - European journal of vascular and endovascular surgery : the official journal of 
      the European Society for Vascular Surgery
JID - 9512728
SB  - IM
CIN - Eur J Vasc Endovasc Surg. 2019 Sep;58(3):409. PMID: 31126836
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Double-Blind Method
MH  - Endovascular Procedures/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Radiofrequency Ablation/*methods
MH  - Saphenous Vein/diagnostic imaging/*surgery
MH  - Surgery, Computer-Assisted/*methods
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ultrasonography, Doppler, Duplex
MH  - Varicose Veins/diagnosis/*surgery
MH  - Young Adult
OTO - NOTNLM
OT  - Closurefast
OT  - Endovenous radiofrequency
OT  - Radiofrequency induced thermal therapy
OT  - Thermal ablation
OT  - Varicose veins
EDAT- 2019/07/29 06:00
MHDA- 2020/04/03 06:00
CRDT- 2019/07/29 06:00
PHST- 2018/08/22 00:00 [received]
PHST- 2019/01/28 00:00 [accepted]
PHST- 2019/07/29 06:00 [pubmed]
PHST- 2020/04/03 06:00 [medline]
PHST- 2019/07/29 06:00 [entrez]
AID - S1078-5884(19)30107-8 [pii]
AID - 10.1016/j.ejvs.2019.01.033 [doi]
PST - ppublish
SO  - Eur J Vasc Endovasc Surg. 2019 Sep;58(3):401-408. doi: 
      10.1016/j.ejvs.2019.01.033. Epub 2019 Jul 24.