PMID- 31351927
OWN - NLM
STAT- MEDLINE
DCOM- 20201005
LR  - 20201005
IS  - 1873-4995 (Electronic)
IS  - 0168-3659 (Linking)
VI  - 309
DP  - 2019 Sep 10
TI  - Drug delivery systems based on intrinsically conducting polymers.
PG  - 244-264
LID - S0168-3659(19)30450-X [pii]
LID - 10.1016/j.jconrel.2019.07.035 [doi]
AB  - This work provides an overview of the up to date research related to 
      intrinsically conducting polymers (ICPs) and their function as novel drug 
      delivery systems (DDSs). Drugs administrated to patients do not always reach the 
      targeted organ, which may affect other tissues leading to undesired side-effects. 
      To overcome these problems, DDSs are under development. Nowadays, it is possible 
      to target the administration and, most importantly, to achieve a controlled drug 
      dosage upon external stimuli. Particularly, the attention of this work focuses on 
      the drug release upon electrical stimuli employing ICPs. These are well-known 
      organic polymers with outstanding electrical properties similar to metals but 
      also retaining some advantageous characteristics normally related to polymers, 
      like mechanical stability and easiness of processing. Depending on the redox 
      state, ICPs can incorporate or release anionic or cationic molecules on-demand. 
      Besides, the releasing rate can be finely tuned by the type of electrical 
      stimulation applied. Another interesting feature is that ICPs are capable to 
      sense redox molecules such as dopamine, serotonin or ascorbic acid among others. 
      Therefore, future prospects go towards the design of materials where the 
      releasing rate could be self-adjusted in response to changes in the surrounding 
      environment. This recompilation of ideas and projects provides a critic outline 
      of ICPs synthesis progress related to their use as DDSs. Definitely, ICPs are a 
      very promising branch of DDSs where the dose can be finely tuned by the exertion 
      of an external stimulus, hence optimizing the repercussions of the drug and 
      diminishing its side effects.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Puiggali-Jou, Anna
AU  - Puiggali-Jou A
AD  - Departament d'Enginyeria Quimica, EEBE, Universitat Politecnica de Catalunya, C/ 
      Eduard Maristany, 10-14, Ed. I2, 08019 Barcelona, Spain; Barcelona Research 
      Center for Multiscale Science and Engineering, Universitat Politecnica de 
      Catalunya, C/ Eduard Maristany, 10-14, Ed. C, 08019 Barcelona, Spain. Electronic 
      address: anna.puiggali@upc.edu.
FAU - Del Valle, Luis J
AU  - Del Valle LJ
AD  - Departament d'Enginyeria Quimica, EEBE, Universitat Politecnica de Catalunya, C/ 
      Eduard Maristany, 10-14, Ed. I2, 08019 Barcelona, Spain; Barcelona Research 
      Center for Multiscale Science and Engineering, Universitat Politecnica de 
      Catalunya, C/ Eduard Maristany, 10-14, Ed. C, 08019 Barcelona, Spain.
FAU - Aleman, Carlos
AU  - Aleman C
AD  - Departament d'Enginyeria Quimica, EEBE, Universitat Politecnica de Catalunya, C/ 
      Eduard Maristany, 10-14, Ed. I2, 08019 Barcelona, Spain; Barcelona Research 
      Center for Multiscale Science and Engineering, Universitat Politecnica de 
      Catalunya, C/ Eduard Maristany, 10-14, Ed. C, 08019 Barcelona, Spain; Institute 
      for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and 
      Technology, Baldiri Reixac 10-12, 08028 Barcelona, Spain. Electronic address: 
      carlos.aleman@upc.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190725
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Polymers)
SB  - IM
MH  - Animals
MH  - Delayed-Action Preparations/*chemistry
MH  - Drug Delivery Systems/*methods
MH  - Drug Liberation
MH  - Electric Conductivity
MH  - Electric Stimulation/methods
MH  - Humans
MH  - Pharmaceutical Preparations/*administration & dosage
MH  - Pharmacokinetics
MH  - Polymers/*chemistry
OTO - NOTNLM
OT  - Controlled release
OT  - DDS
OT  - Drug delivery
OT  - Electrical stimuli
OT  - ICP
OT  - Intrinsically conducting polymers
EDAT- 2019/07/29 06:00
MHDA- 2020/10/06 06:00
CRDT- 2019/07/29 06:00
PHST- 2019/05/17 00:00 [received]
PHST- 2019/07/23 00:00 [revised]
PHST- 2019/07/24 00:00 [accepted]
PHST- 2019/07/29 06:00 [pubmed]
PHST- 2020/10/06 06:00 [medline]
PHST- 2019/07/29 06:00 [entrez]
AID - S0168-3659(19)30450-X [pii]
AID - 10.1016/j.jconrel.2019.07.035 [doi]
PST - ppublish
SO  - J Control Release. 2019 Sep 10;309:244-264. doi: 10.1016/j.jconrel.2019.07.035. 
      Epub 2019 Jul 25.