PMID- 31352196
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231013
IS  - 1936-5233 (Print)
IS  - 1936-5233 (Electronic)
IS  - 1936-5233 (Linking)
VI  - 12
IP  - 10
DP  - 2019 Oct
TI  - Hedgehog Signaling: An Achilles' Heel in Cancer.
PG  - 1334-1344
LID - S1936-5233(19)30199-8 [pii]
LID - 10.1016/j.tranon.2019.07.004 [doi]
AB  - Hedgehog signaling pathway originally identified in the fruit fly Drosophila is 
      an evolutionarily conserved signaling mechanism with crucial roles in 
      embryogenesis, growth and patterning. It exerts its biological effect through a 
      signaling mechanism that terminates at glioma-associated oncogene (GLI) 
      transcription factors which alternate between activator and repressor forms and 
      mediate various responses. The important components of the pathway include the 
      hedgehog ligands (SHH), the Patched (PTCH) receptor, Smoothened (SMO), Suppressor 
      of Fused (SuFu) and GLI transcription factors. Activating or inactivating 
      mutations in key genes cause uncontrolled activation of the pathway in a ligand 
      independent manner. The ligand-dependent aberrant activation of the hedgehog 
      pathway causing overexpression of hedgehog pathway components and its target 
      genes occurs in autocrine as well as paracrine fashion. In adults, aberrant 
      activation of hedgehog signaling has been linked to birth defects and multiple 
      solid cancers. In this review, we assimilate data from recent studies to 
      understand the mechanism of functioning of the hedgehog signaling pathway, role 
      in cancer, its association in various solid malignancies and the current 
      strategies being used to target this pathway for cancer treatment.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Niyaz, Madiha
AU  - Niyaz M
AD  - Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences 
      (SKIMS), Soura, - 190011 Srinagar, Kashmir.
FAU - Khan, Mosin S
AU  - Khan MS
AD  - Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences 
      (SKIMS), Soura, - 190011 Srinagar, Kashmir.
FAU - Mudassar, Syed
AU  - Mudassar S
AD  - Department of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences 
      (SKIMS), Soura, - 190011 Srinagar, Kashmir. Electronic address: 
      syed.mudassar@skims.ac.in.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190725
PL  - United States
TA  - Transl Oncol
JT  - Translational oncology
JID - 101472619
PMC - PMC6664200
EDAT- 2019/07/29 06:00
MHDA- 2019/07/29 06:01
PMCR- 2019/07/25
CRDT- 2019/07/29 06:00
PHST- 2019/04/26 00:00 [received]
PHST- 2019/07/02 00:00 [revised]
PHST- 2019/07/08 00:00 [accepted]
PHST- 2019/07/29 06:00 [pubmed]
PHST- 2019/07/29 06:01 [medline]
PHST- 2019/07/29 06:00 [entrez]
PHST- 2019/07/25 00:00 [pmc-release]
AID - S1936-5233(19)30199-8 [pii]
AID - 10.1016/j.tranon.2019.07.004 [doi]
PST - ppublish
SO  - Transl Oncol. 2019 Oct;12(10):1334-1344. doi: 10.1016/j.tranon.2019.07.004. Epub 
      2019 Jul 25.